Stimulation site and phase modulation of the withdrawal reflex during gait initiation

Richard, Miguel; Spaich, Erika G.; Serrao, Mariano; Andersen, Ole Kæseler

doi:10.1016/j.clinph.2015.01.019

Cited by 10 publications

(6 citation statements)

References 31 publications

(51 reference statements)

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“…The cats required different ES programs, adapted to each case and their neurological evolution (i.e., presence of knuckling position). For example, FES for the extensor muscles of the carpus with a precise trapezoid current and parameters adjusted to DPP was used to generate an action potential strong enough for nerve depolarization and consequent muscle contraction [89]. Also, accurate placement of electrodes is crucial for opposing the low current that makes physiological contraction impossible under these conditions [90].…”

Section: Discussionmentioning

confidence: 99%

The Role of Early Rehabilitation and Functional Electrical Stimulation in Rehabilitation for Cats with Partial Traumatic Brachial Plexus Injury: A Pilot Study on Domestic Cats in Portugal

Gouveia,

Cardoso,

Carvalho

et al. 2024

Animals

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This prospective observational cohort pilot study included 22 cats diagnosed with partial traumatic brachial plexus injury (PTBPI), aiming to explore responses to an early intensive neurorehabilitation protocol in a clinical setting. This protocol included functional electrical stimulation (FES), locomotor treadmill training and kinesiotherapy exercises, starting at the time with highest probability of nerve repair. The synergetic benefits of this multimodal approach were based on the potential structural and protective role of proteins and the release of neurotrophic factors. Furthermore, FES was parametrized according to the presence or absence of deep pain. Following treatment, 72.6% of the cats achieved ambulation: 9 cats within 15 days, 2 cats within 30 days and 5 cats within 60 days. During the four-year follow-up, there was evidence of improvement in both muscle mass and muscle weakness, in addition to the disappearance of neuropathic pain. Notably, after the 60 days of neurorehabilitation, 3 cats showed improved ambulation after arthrodesis of the carpus. Thus, early rehabilitation, with FES applied in the first weeks after injury and accurate parametrization according to the presence or absence of deep pain, may help in functional recovery and ambulation, reducing the probability of amputation.

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Section: Discussionmentioning

confidence: 99%

The Role of Early Rehabilitation and Functional Electrical Stimulation in Rehabilitation for Cats with Partial Traumatic Brachial Plexus Injury: A Pilot Study on Domestic Cats in Portugal

Gouveia,

Cardoso,

Carvalho

et al. 2024

Animals

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“…Notably, a reflex study performed in healthy humans has shown the inhibition of voluntarily contracted muscles when a stimulus is applied in its inhibitory receptive field (Sonnenborg et al, 2000). Other studies assessing the NWR during rhythmic muscle contraction (e.g., gait) further support the existence of an inhibitory phenomenon between reflex receptive fields of nonsynergistic muscles in healthy humans (Richard et al, 2015). F I G U R E 9 Word clouds generated for the pain quality observation when using single stimulation (A) and double stimulation (B).…”

Section: Spinal Integration During Double Stimulationmentioning

confidence: 92%

Spinal spatial integration of nociception and its functional role assessed via the nociceptive withdrawal reflex and psychophysical measures in healthy humans

2020

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Many pain-related conditions are characterized by poorly localized pain areas in the body which is likely to reflect abnormal processing of spatial characteristics of the noxious phenomenon driving the condition (Gran, 2003; Graven-Nielsen & Arendt-Nielsen, 2010; Kamaleri et al., 2008; Wolfe et al., 1990). Within the spinal cord, several primary afferents converge onto spinal neurons and constitute the first relay for somatosensory integration. Electrophysiological studies in animals have shown that neurons located in this first relay play a role in

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“…Intralimb hip–knee coordination may be promoted by the combination of FES and locomotor training [ 37 , 38 , 39 ]. In chronic patients, electrical stimulation protocols with FES and Transcutaneous Electrical Spinal Cord Stimulation (TESCS) could be applied as a possible therapeutic neurorehabilitation tool for IVDD [ 40 , 41 , 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Functional Neurorehabilitation in Dogs with an Incomplete Recovery 3 Months following Intervertebral Disc Surgery: A Case Series

Martins

Gouveia²,

Cardoso³

et al. 2021

Animals

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This case series study aimed to evaluate the safety, feasibility, and positive outcome of the neurorehabilitation multimodal protocol (NRMP) in 16 chronic post-surgical IVDD Hansen type I dogs, with OFS 0/DPP− (n = 9) and OFS 1/DPP+ (n = 7). All were enrolled in the NRMP for a maximum of 90 days and were clinically discharged after achieving ambulation. The NRMP was based on locomotor training, functional electrical stimulation, transcutaneous electrical spinal cord stimulation, and 4-aminopyridine (4-AP) pharmacological management. In the Deep Pain Perception (DPP)+ dogs, 100% recovered ambulation within a mean period of 47 days, reaching OFS ≥11, which suggests that a longer period of time is needed for recovery. At follow-up, all dogs presented a positive evolution with voluntary micturition. Of the DPP− dogs admitted, all achieved a flexion/extension locomotor pattern within 30 days, and after starting the 4-AP, two dogs were discharged at outcome day 45, with 78% obtaining Spinal Reflex Locomotion (SRL) and automatic micturition within a mean period of 62 days. At follow-up, all dogs maintained their neurological status. After the NRMP, ambulatory status was achieved in 88% (14/16) of dogs, without concurrent events. Thus, an NRMP may be an important therapeutic option to reduce the need for euthanasia in the clinical setting.

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Stimulation site and phase modulation of the withdrawal reflex during gait initiation

Cited by 10 publications

References 31 publications

The Role of Early Rehabilitation and Functional Electrical Stimulation in Rehabilitation for Cats with Partial Traumatic Brachial Plexus Injury: A Pilot Study on Domestic Cats in Portugal

The Role of Early Rehabilitation and Functional Electrical Stimulation in Rehabilitation for Cats with Partial Traumatic Brachial Plexus Injury: A Pilot Study on Domestic Cats in Portugal

Spinal spatial integration of nociception and its functional role assessed via the nociceptive withdrawal reflex and psychophysical measures in healthy humans

Functional Neurorehabilitation in Dogs with an Incomplete Recovery 3 Months following Intervertebral Disc Surgery: A Case Series

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