Stimuli-responsive chitosan as an advantageous platform for efficient delivery of bioactive agents

Sabourian, Parinaz; Tavakolian, Mandana; Yazdani, Hossein; Frounchi, Masoud; Ven, Theo G. M. van de; Maysinger, Dušica; Kakkar, Ashok

doi:10.1016/j.jconrel.2019.11.029

Cited by 93 publications

(49 citation statements)

References 173 publications

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“…[ 68,71 ] Ultrasound‐responsive polymers like Pluronic micelles, ethylene vinyl acetate copolymer, chitosan, PEG‐PLA copolymers, poly(methacrylic acid), and so on are used to trigger the release of drug from the core of nanocarriers. [ 50–52,55,72 ] Drugs incorporated with ultrasound contrast agents provide a way to record the pathways of drug release on an optical device. Identification of the onset of epilepsy; however, may be observed conventionally with the use of EEG or similar devices.…”

Section: Nanotheranostic Strategies In Epilepsymentioning

confidence: 99%

Nanotheranostics in epilepsy: A perspective for multimodal diagnosis and strategic management

Shende

Trivedi

2021

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Epilepsy is a common but a complex neurological disorder with limited practices for successful management due to the complicated neuronal network and lack of knowledge of epileptic pathophysiology. Theranostic systems such as implantable devices and biodegradable nanomaterials offer better tailor‐made methods for the detection and treatment using nanotechnology‐based approaches for patients with epilepsy. Miniaturized nano‐implantable devices and biosensors equipped with operations to mimic neurostimulation demonstrate excellent opportunities in profiling the disease and assist in comprehension of the relationship between the disease and host. This strategy is developed for diagnoses and mapping brain activities to integrate and target therapeutic nanosystems in epilepsy. Non‐invasive class of nanotheranostics such as biodegradable and stimuli‐responsive polymers includes nanomaterials that utilize bio‐physico‐chemical processes or stimuli as a source for detecting the state and progress of the disease. The superior form of nanotheranostics encompasses in‐situ diagnostics with triggered release at the specific site. This review article focuses on the nanotheranostic strategies for epilepsy, their implications, challenges and new potentials for detection and therapy in personalized medicine. The concept of “on‐demand” release of drugs at the site of action using bio‐responsive theranostic approach reveals a potential for developing a point of primary care for epilepsy in the future.

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Section: Nanotheranostic Strategies In Epilepsymentioning

confidence: 99%

Nanotheranostics in epilepsy: A perspective for multimodal diagnosis and strategic management

Shende

Trivedi

2021

Nano Select

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“…It afforded 5,5′-(((2,2-bis(((3bromoisoxazol-5-yl)methoxy)methyl)propane-1,3-diyl)bis(oxy))bis(methylene))bis(3bromoisoxazole) (5) in 44% isolated yield (Scheme 1) [33]. A tremendous research effort has been devoted to developing nanocarriers that could deliver active pharmaceutical agents to the sites affected by pathological changes to minimize wide body distribution and reduce undesirable side effects [20,21]. Amphiphilic linear block copolymers have been extensively explored in assembling core-corona type spherical micelle structures for drug delivery [22].…”

Section: Synthesismentioning

confidence: 99%

“…Macromolecular therapeutics are increasingly proposed as nanomedicines [19] and new methodologies to prepare highly potent isoxazoles bearing nanocarriers and nanotherapeutics will likely expand the scope of their applications. A tremendous research effort has been devoted to developing nanocarriers that could deliver active pharmaceutical agents to the sites affected by pathological changes to minimize wide body distribution and reduce undesirable side effects [20,21]. Amphiphilic linear block copolymers have been extensively explored in assembling core-corona type spherical micelle structures for drug delivery [22].…”

Section: Introductionmentioning

confidence: 99%

Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology

et al. 2020

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An architectural polymer containing hydrophobic isoxazole-based dendron and hydrophilic polyethylene glycol linear tail is prepared by a combination of the robust ZnCl2 catalyzed alkyne-nitrile oxide 1,3-dipolar cycloaddition and esterification chemistry. This water soluble amphiphilic telodendrimer acts as a macromolecular biologically active agent and shows concentration dependent reduction of glioblastoma (U251) cell survival.

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“…In a medicinal context, there is currently much interest in naturally occurring hydrogels of carbohydrate (e.g., alginate, chitosan) and protein (e.g., serum albumin) origin, as they tend to be non-toxic, biocompatible and biodegradable [1][2][3]. Moreover, there is extensive current interest in enhancing the properties of these biopolymers by incorporating antimicrobial agents into the polymer matrix for applications in food packaging, wound dressings, and drug delivery [4][5][6]. With increasing antimicrobial resistance to conventional antibiotics becoming a global healthcare problem, there has been a resurgence in the study of metal based complexes as antimicrobial agents [7].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ions

et al. 2021

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Calcium alginate (CaALG) hydrogel beads and two sets of composite beads, formed from a combination of calcium alginate/propylene glycol alginate/human serum albumin (CaALG/PGA/HSA) and from calcium alginate with the quaternary ammonium salt, (3-(trimethoxysilyl)propyl)-octadecyldimethylammonium chloride (QA), (CaALG/QA), were prepared. Bovine serum albumin (BSA) was condensed with glutaraldehyde (GLA) to form a BSA/GLA hydrogel. The corresponding Ag+-containing gels of all of the above hydrogels were also formed, and slow leaching of the biocidal transition metal ion from the gels bestowed broad spectrum antimicrobial activity. In the absence of added Ag+, CaALG/QA was the only material to deliver marginal to moderate antibacterial and antifungal effects. The Ag+ impregnated hydrogel systems have the potential to maintain the antimicrobial properties of silver, minimising the risk of toxicity, and act as reservoirs to afford ongoing sterility.

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Stimuli-responsive chitosan as an advantageous platform for efficient delivery of bioactive agents

Cited by 93 publications

References 173 publications

Nanotheranostics in epilepsy: A perspective for multimodal diagnosis and strategic management

Nanotheranostics in epilepsy: A perspective for multimodal diagnosis and strategic management

Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology

Preparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ions

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