Stimuli-responsive glycopolymers and their biological applications

Jafari, Farnaz; Yilmaz, Gökhan; Becer, C. Remzi

doi:10.1016/j.eurpolymj.2020.110147

Cited by 9 publications

(14 citation statements)

References 63 publications

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Section: Resultsmentioning

confidence: 99%

“…54 It is well documented that the same glycocluster effect that occurs in biological systems can also promote strong binding between some synthetic glycopolymers and certain lectins. [55][56][57] Biological recognition of sugar residues on glycopolymers can be beneficial for some applications, e.g., targeted drug delivery or microbial antiadhesion; however, it may not be desired when biological inertness is required, e.g., when glycopolymers are used as stabilizing excipients in pharmaceutical formulations. To our knowledge, the potential biorecognition of trehalose-or sucrose-bearing polymers has not yet been studied.…”

Section: Affinity Of Glycopolymers To Model α-D-glucopyranosyl Residu...mentioning

confidence: 99%

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Structurally analogous trehalose and sucrose glycopolymers – comparative characterization and evaluation of their effects on insulin fibrillation

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Section: Affinity Of Glycopolymers To Model α-D-glucopyranosyl Residu...mentioning

confidence: 99%

Structurally analogous trehalose and sucrose glycopolymers – comparative characterization and evaluation of their effects on insulin fibrillation

et al. 2022

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“…The synthesized polymers displayed polydispersity with sufficient multivalent effects to serve as biomaterials [ 26 ]. The most noteworthy property of glycopolymers is their ability to interact with lectins and particular cells in various ways, depending on their sugar moieties [ 27 ]. The kind of sugar moiety, the linkage position, the density of sugars, and the degree of polymerization and branching influence the intensity of interactions [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

“…Cell surface saccharides, such as glycolipids, glycoproteins, and glycans, are connected to various biological activities, including cellular contacts, adhesion, cancer cell metastasis, and pathogen infection, all mediated by protein-saccharide interactions [ 29 ]. Because the protein-saccharide interaction is weak, the multivalent impact of clustered saccharides, known as the glycocluster effect [ 27 ], can improve it. Because of their biorecognition characteristics, glycopolymers are promising materials for future biomedical applications such as drug or gene delivery and biosensing.…”

Section: Introductionmentioning

confidence: 99%

Glycopolymer-Based Materials: Synthesis, Properties, and Biosensing Applications

et al. 2022

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Glycopolymer materials have emerged as a significant biopolymer class that has piqued the scientific community's attention due to their potential applications. Recently, they have been found to be a unique synthetic biomaterial; glycopolymer materials have also been used for various applications, including direct therapeutic methods, medical adhesives, drug/gene delivery systems, and biosensor applications. Therefore, for the next stage of biomaterial research, it is essential to understand current breakthroughs in glycopolymer-based materials research. This review discusses the most widely utilized synthetic methodologies for glycopolymer-based materials, their properties based on structure–function interactions, and the significance of these materials in biosensing applications, among other topics. When creating glycopolymer materials, contemporary polymerization methods allow precise control over molecular weight, molecular weight distribution, chemical activity, and polymer architecture. This review concludes with a discussion of the challenges and complexities of glycopolymer-based biosensors, in addition to their potential applications in the future. Graphical Abstract

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“…Carbohydrates play an important role in many biological processes related to cancer metastasis, cell growth, and inflammation. They can be used as targeted drug delivery tools because they are biocompatible and biodegradable biomacromolecules that exhibit high cellular accumulation and recognition by the specific membrane proteins . Among various sugars, fructose molecules possess a unique biocompatibility and specific recognition by GLUT5 (a well-known fructose transporter) overexpressed in breast cancer cells as described in the literature. − Owing to the remarkable properties associated with carbohydrates, glycopolymer is considered to be a suitable candidate for creating multifunctional materials for breast cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Phthalocyanine-Conjugated Glyconanoparticles for Chemo-photodynamic Combination Therapy

et al. 2021

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Combination cancer therapy based on multifunctional nanomaterials has attracted great attention. The present work focuses on the preparation of the glycopolymeric nanoparticle, which contains a photosensitizer (zinc(II)phthalocyanine, ZnPc) and an anticancer drug (Doxorubicin, Dox). First, a novel mono azide-functional ZnPc-N 3 with seven hydrophilic ethylene oxide chains was synthesized. Next, ZnPc alone or together with Dox bearing glycopolymers was synthesized via the RAFT polymerization method and then self-assembled into glyconanoparticles (GNPs) with narrow particle size distribution. Then the evaluation of the biological activity of GNPs (GNPs-ZnPc and GNPs-ZnPc/Dox) for dual photodynamic therapy (PDT) and chemotherapy against human breast cancer cells was investigated. The constructed GNPs were identified via general characterization methods, including dynamic light scattering (DLS) and transmission electron microscopy (TEM). The prepared GNPs-ZnPc/Dox demonstrated remarkable photophysical and photochemical properties, involving good colloidal stability in biological conditions, pH-responsive drug release, and the capacity to generate singlet oxygen under light irradiation. The outer layer of nanoparticles covered by fructose sugar moieties achieves a targeted cancer therapy owing to GLUT5 (a well-known fructose transporter) overexpression toward breast cancer cells. In vitro experiments were then performed to evaluate the chemo/phototoxicity, cellular uptake, and anticancer efficacy of GNPs-ZnPc/Dox. In comparison with free Dox, human breast cancer cells treated with GNPs-ZnPc/Dox exhibited a higher cellular internalization via GLUT5 targeting. In particular, the GNPs-ZnPc/Dox nanoplatform revealed an excellent synergistic anticancer activity in comparison with free ZnPc-N 3 and free Dox, representing a novel and promising chemophotodynamic combination therapeutic methodology to improve therapeutic efficacy.

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Stimuli-responsive glycopolymers and their biological applications

Cited by 9 publications

References 63 publications

Structurally analogous trehalose and sucrose glycopolymers – comparative characterization and evaluation of their effects on insulin fibrillation

Structurally analogous trehalose and sucrose glycopolymers – comparative characterization and evaluation of their effects on insulin fibrillation

Glycopolymer-Based Materials: Synthesis, Properties, and Biosensing Applications

Phthalocyanine-Conjugated Glyconanoparticles for Chemo-photodynamic Combination Therapy

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