Stimuli-Responsive Nanomaterials for Application in Antitumor Therapy and Drug Delivery

Pham, Son H.; Choi, Yonghyun; Choi, Jonghoon

doi:10.3390/pharmaceutics12070630

Cited by 143 publications

(76 citation statements)

References 109 publications

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“…Adenosine triphosphate-coated (ATC) enzyme-sensitive silver nanoparticles are especially engaging because of their astounding stability in a typical physiological climate and controllable suppression of liver carcinoma cells in humans Enzyme-responsive drug delivery systems are usually built from nanomaterials such as polymers or inorganic materials. Different enzymes particular to certain tumors can influence the peptide structure or the ester bonds from nanocarriers, by releasing the loaded drug at desired locations [120][121][122]. In enzyme-responsive drug delivery systems, the most used triggers are proteases and phospholipases [122].…”

Section: Enzyme-responsive Nanomaterialsmentioning

confidence: 99%

Smart Nanomaterials for Biomedical Applications—A Review

Aflori¹

2021

Nanomaterials

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Recent advances in nanotechnology have forced the obtaining of new materials with multiple functionalities. Due to their reduced dimensions, nanomaterials exhibit outstanding physio-chemical functionalities: increased absorption and reactivity, higher surface area, molar extinction coefficients, tunable plasmonic properties, quantum effects, and magnetic and photo properties. However, in the biomedical field, it is still difficult to use tools made of nanomaterials for better therapeutics due to their limitations (including non-biocompatible, poor photostabilities, low targeting capacity, rapid renal clearance, side effects on other organs, insufficient cellular uptake, and small blood retention), so other types with controlled abilities must be developed, called “smart” nanomaterials. In this context, the modern scientific community developed a kind of nanomaterial which undergoes large reversible changes in its physical, chemical, or biological properties as a consequence of small environmental variations. This systematic mini-review is intended to provide an overview of the newest research on nanosized materials responding to various stimuli, including their up-to-date application in the biomedical field.

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Section: Enzyme-responsive Nanomaterialsmentioning

confidence: 99%

Smart Nanomaterials for Biomedical Applications—A Review

Aflori¹

2021

Nanomaterials

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“…Hence, developing stimuli-responsive polymeric nanoparticles that can specifically respond to TME offers promising strategies for combating cancer (Jiang et al, 2020;Qi et al, 2021). Recently, the progress of stimuli-responsive nanomaterials has improved dramatically in cancer treatment (Fleige et al, 2012;Yu J. et al, 2014;Karimi et al, 2016;Alsehli, 2020;Pham et al, 2020;Xie et al, 2020). The stimuli can be divided into internal and external stimuli.…”

Section: Theranostic Polymeric Nanomaterials For Cancermentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanoplatforms for Cancer Therapy

Chen

et al. 2021

Front. Bioeng. Biotechnol.

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Polymeric nanoparticles have been widely used as carriers of drugs and bioimaging agents due to their excellent biocompatibility, biodegradability, and structural versatility. The principal application of polymeric nanoparticles in medicine is for cancer therapy, with increased tumor accumulation, precision delivery of anticancer drugs to target sites, higher solubility of pharmaceutical properties and lower systemic toxicity. Recently, the stimuli-responsive polymeric nanoplatforms attracted more and more attention because they can change their physicochemical properties responding to the stimuli conditions, such as low pH, enzyme, redox agents, hypoxia, light, temperature, magnetic field, ultrasound, and so on. Moreover, the unique properties of stimuli-responsive polymeric nanocarriers in target tissues may significantly improve the bioactivity of delivered agents for cancer treatment. This review introduces stimuli-responsive polymeric nanoparticles and their applications in tumor theranostics with the loading of chemical drugs, nucleic drugs and imaging molecules. In addition, we discuss the strategy for designing multifunctional polymeric nanocarriers and provide the perspective for the clinical applications of these stimuli-responsive polymeric nanoplatforms.

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“…Light as an external stimulus for drug-delivery systems is dominant for many reasons, such as its noninvasive nature, temporal control, and high spatial resolution, in addition to its convenience and ease of use [ 35 ]. Thus, nano-preparations that are responsive to light stimulus have been intensively investigated as they can distantly control drug delivery upon the presence of different wavelengths, either ultraviolet (UV) or near-infrared (NIR) [ 36 ].…”

Section: Targeted Mechanisms For Nanohybrid Liposomal-metallic Sysmentioning

confidence: 99%

Smart Stimuli-Responsive Liposomal Nanohybrid Systems: A Critical Review of Theranostic Behavior in Cancer

et al. 2021

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The epoch of nanotechnology has authorized novel investigation strategies in the area of drug delivery. Liposomes are attractive biomimetic nanocarriers characterized by their biocompatibility, high loading capacity, and their ability to reduce encapsulated drug toxicity. Nevertheless, various limitations including physical instability, lack of site specificity, and low targeting abilities have impeded the use of solo liposomes. Metal nanocarriers are emerging moieties that can enhance the therapeutic activity of many drugs with improved release and targeted potential, yet numerous barriers, such as colloidal instability, cellular toxicity, and poor cellular uptake, restrain their applicability in vivo. The empire of nanohybrid systems has shelled to overcome these curbs and to combine the criteria of liposomes and metal nanocarriers for successful theranostic delivery. Metallic moieties can be embedded or functionalized on the liposomal systems. The current review sheds light on different liposomal-metal nanohybrid systems that were designed as cellular bearers for therapeutic agents, delivering them to their targeted terminus to combat one of the most widely recognized diseases, cancer.

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Stimuli-Responsive Nanomaterials for Application in Antitumor Therapy and Drug Delivery

Cited by 143 publications

References 109 publications

Smart Nanomaterials for Biomedical Applications—A Review

Smart Nanomaterials for Biomedical Applications—A Review

Stimuli-Responsive Polymeric Nanoplatforms for Cancer Therapy

Smart Stimuli-Responsive Liposomal Nanohybrid Systems: A Critical Review of Theranostic Behavior in Cancer

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