sTNFR-1 is an early inflammatory marker in community versus institutionalized elderly women

Coelho, Fernanda; Narciso, F. M. S.; Oliveira, Daniela Matos Garcia; Pereira, Daniele Sirineu; Teixeira, Antônio Lúcio; Teixeira, Mauro Martins; Souza, Danielle G.; Pereira, Leani Souza Máximo

doi:10.1007/s00011-009-0079-6

Cited by 17 publications

(13 citation statements)

References 29 publications

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“…In our study, even though IL-6 plasma levels were low and sTNFR1 levels were high, there was no impairment of muscle function, grip strength, or gait velocity test performance related to these altered levels. Our results agree with the study of Coelho et al (2010) [7] , who reported an increase in sTNFR1 levels in elderly community dwellers with no impact of handgrip strength. The present study findings indicate that changes in inflammatory cytokines occur at a cellular level before loss of muscle strength and deterioration on functional performance, that is, the adverse repercussions related to the high levels of Inflammatory mediators may become apparent in the long term.…”

Section: Inflammatory Mediators and Physical Function In Community Elsupporting

confidence: 82%

Systemic inflammation and physical function in community elderly women

Felício

Pereira²,

Assumpção³

et al. 2014

Inflamm Cell Signal

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Multiple inter-related factors that contribute to the development and progression of sarcopenia in the elderly. Sarcopenia is enhanced by immunosenescence, in which the induction and expression of inflammatory mediators such as IL-6 and TNF-α increase significantly. Elevation of inflammatory cytokine levels are a predictor of mortality and morbidly in the elderly and have a catabolic effect on muscle proteins. Our studies show that there is no a cutoff point to predict adverse physical and functional outcomes, the data found are conflicting. More research is needed to clarify the role of systemic inflammation in muscle and functional performance in elderly women.

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Section: Inflammatory Mediators and Physical Function In Community Elsupporting

confidence: 82%

Systemic inflammation and physical function in community elderly women

Felício

Pereira²,

Assumpção³

et al. 2014

Inflamm Cell Signal

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“…This finding demonstrates that high levels of sTNFR1 represent lowgrade inflammation present in nonagenarian elderly, which could negatively influence the training capacity of these individuals. In a recent study, Coelho et al found that concentrations of sTNFR1 were higher in elderly subjects when compared to younger subjects living in the same community and that these concentrations correlated with the age of volunteers [35].…”

Section: Discussionmentioning

confidence: 98%

Effect of aerobic training on plasma cytokines and soluble receptors in elderly women with knee osteoarthritis, in response to acute exercise

et al. 2012

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The aim of this study was to evaluate levels of interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and soluble forms of the TNF-α receptor (sTNFR1 and sTNFR2) from plasma taken from the peripheral blood of elderly individuals presenting with osteoarthritis (OA) of the knee. These patients underwent aerobic treatment through the use of physical exercises. The study consisted of a longitudinal analysis of older individuals presenting clinical and radiographic diagnosis of knee OA that were submitted to 12 weeks of aerobic treatment. The individuals were evaluated during acute exercise or after chronic exercise. During acute exercise (walking slowly on the mat), blood samples of the patients were collected before, immediately after, and 30 min following the end of training. After chronic exercise (aerobic walking training, three times/week for 12 weeks), patient blood samples were obtained for comparison. Additionally, clinical and functional assessments (WOMAC test and 6-min walk) were performed at the end of all physical exercises. Plasma concentrations of cytokines and soluble receptors were measured by ELISA. Aerobic training increased the plasma concentration of sTNR1; however, it decreased the plasma concentration of sTNFR2, when compared with levels of resting patients. Acute exercise differentially affects the levels of sTNFR1 dependent on when the samples were taken, before and after aerobic training. However, the levels of sTNFR2 were not affected by training. For the population studied, we observed differences in the levels of sTNFR1 and sTNFR2 following acute and chronic exercise. Other additional factors, like the level of inactivity of the individual and the type of physical exercise that patients are exposed to, need to be considered as well. The variation in the levels of soluble receptors correlated with functional improvement; however, the inflammatory osteoarthritis markers (IL-6 and TNF-α) were unaffected by the walking exercises.

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“…Values of less than 31 cm were considered indicative of depleted muscle mass and correlated with incapacity. 16 The AMMI and body composition assessments were performed using Dual Energy X-Ray Absorptiometry (DXA, Discovery A Hologic model). These assessments were conducted in the Laboratório Bioquímico e Densitométrico (Biochemistry and Densitometry Laboratory) (LABDEN) of the Universidade Tecnológica Federal do Paraná (Federal University of Technology of Paraná).…”

Section: Sarcopenia Indicatorsmentioning

confidence: 99%

Indicators of sarcopenia and their relation to intrinsic and extrinsic factors relating to falls among active elderly women

Rossetin

Rodrigues

Gallo

et al. 2016

Rev. bras. geriatr. gerontol.

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Introduction: Musculoskeletal aging can impair functional performance increasing the risk of falls. Objective: To analyze the correlation between sarcopenia and the intrinsic and extrinsic factors involved in falls among community-dwelling elderly women. Method: A cross-sectional study evaluated the number of falls of 85 active community-dwelling elderly women in the previous year and then divided them into two groups: non-fallers (n=61) and fallers (n=24). The sarcopenia indicators assessed were gait speed (GS, 10m); handgrip strength (HS); calf circumference; appendicular muscle mass index (DXA). Intrinsic factors: Mental State Examination (MSE); visual acuity; depression (GDS-30); hip, knee (Lequesne) and ankle/foot (FAOS) pain/function; vestibular function (Fukuda test); functional mobility and risk of falls (TUG); power (sitting and standing five times); gait (treadmill); fear of falling (FES-I-Brazil). Extrinsic factors: risk/security features in homes. The independent t test was applied for comparisons between groups and the Pearson and Spearman tests were used for correlations (p<0.05). Results: There was a moderate correlation between HS and GS in non-fallers (r=0.47; p=0.001) and fallers (r= 0.54; p=0.03). There was a moderate negative correlation (r= -0.52; p=0.03) between FES-I-Brazil and gait cadence in fallers. There was a greater presence of stairs ( p=0.001) and throw rugs ( p=0.03) in the homes of fallers than non-fallers. Conclusion: The elderly women were not sarcopenic. Elderly fallers presented inferior gait cadence and a greater fear of falling. Residential risks were determining factors for falls, and were more relevant than intrinsic factors in the evaluation of falls among active community-dwelling elders.

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sTNFR-1 is an early inflammatory marker in community versus institutionalized elderly women

Abstract: Our results demonstrate that being institutionalized has an impact on levels of inflammatory markers.

Cited by 17 publications

References 29 publications

Systemic inflammation and physical function in community elderly women

Systemic inflammation and physical function in community elderly women

Effect of aerobic training on plasma cytokines and soluble receptors in elderly women with knee osteoarthritis, in response to acute exercise

Indicators of sarcopenia and their relation to intrinsic and extrinsic factors relating to falls among active elderly women

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