Stoffwechselkrankheiten usw

Abderhalden, Emil

doi:10.1007/978-3-642-91348-8_110

Cited by 1 publication

(9 citation statements)

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“…White female. Weight,1,714 grams. February 1: Autopsy: Cirrhosis of the liver; enteritis of small intestines; stomach and kidneys normal.…”

Section: Rabbit 69mentioning

confidence: 99%

“…Belgian hare, female. Weight,1,175 grams. February 16: 11.05 a. m., 8 cc 2 per cent caffein injected (0.136 gram per kilo) into the lumbar muscles; under observation until 4 p. m., no symptoms; 4 p.m., allowed to walk on the floor; after walking a short distance loss of coordination and paralysis of posterior extremities; 5.20 p. m., found dead.…”

Section: Effect Of Caffein On Renal Secretionmentioning

confidence: 99%

“…Gray female. Weight,1,650 grams. Diet,oats. February 1: Injection began at 3 p. ; 11.10 a. m., 7 cc 2 per cent caffein injected, rabbit struggled; 1 cc was injected during the next three minutes, rabbit struggled but there were no convulsions, injection stopped; resumed at 11.15 a. m. and continued 10 minutes, 8 cc 2 per cent caffein introduced during this time; total amount caffein injected, 16 cc; reflexes markedly increased; 12 noon, tetanic convulsions off and on until 2 p. m., then remained stretched out on abdomen, extremi-In the eight experimentH compriHinp soricH B nibbit.s Noh.…”

Section: Series Bmentioning

confidence: 99%

“…Rabbit 574-Gray female. Weight,1,555 grams. Diet,oats. February 8: 10.25 to 10.33 a. m., injected 4 cc of 0.5 per cent caffein in salt solution, injection discontinued for five minutes; 10.38 to 11.10, injected 30 cc, total amount of caffein solution received, 34 cc; 11.55 a. m., very sensitive; reflexes markedly increased.…”

Section: Series Bmentioning

confidence: 99%

“…Gray female. Weight,1,225 grams. Diet,oats. February 7: 2.06 to 2.35 p. m., injected 24.5 cc 0.5 per cent caffein, reflexes increased but no convulsions, paresis especially marked in the anterior extremities; 3 p. m., passed xuine which was normal in appearance, reflexes not increased but rabbit was weak.…”

Section: Series Bmentioning

confidence: 99%

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The toxicity of caffein: an experimental study on different species of animals

Salant¹,

Rieger²

1912

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About the same time Amory * (1868) published the results of his Studies on the toxicity of caffein in cats, dogs, rabbits, and pigeons. In all cases very large doses were introduced directly into the stomach by means of a temporary gastric fistula. Ten grains given in meat to a dog caused restlessness, but no other symptoms. Doses of 30 grains and above were invariably fatal. Seventy-three grains given to a cat caused death within 20 minutes. From observations on frogs, guinea pigs, rabbits, and on one dog, Leven^^(1868) concluded that caffein which he gave in the form of the citrate in doses of 10 mg to frogs, from 150 to 200 mg to guinea pigs, and three to four times the latter amount to rabbits, stimulates the central nervous system and the voluntary, cardiac, and smooth muscles. He found that 0.9 gram caffein was fatal for a rabbit when injected subcutaneously, while 1 gram of the citrate was not toxic for a dog of medium size. Caffein applied directly to muscle fiber causes tetanus and destroys muscular contractility, while a nerve fiber similarly treated loses its irritability. According to Johansen ** (1869), caffein acts directly on the muscular fiber. After the subcutaneous injection of 0.02 gram of caft'ein into frogs, he observed contraction of the muscles at the site of injection, then contraction of the anterior extremities, and finally the posterior extremities become rigid and extended. Johansen obsei-ved muscular rigidity after caffein, even after curara was injected, or after ligating the vessels, or cutting the nerves which supply the muscles. He also observed that large doses of caffein diminish muscular irritability. When cardiac muscle was poisoned with caffein, microscopical examination showed that the striations disappeared. Johansen also states that reflexes disappear after caffein poisoning. He never observed tetanus in frogs, but reported tonic and clonic convulsions a.s (Doses of 147 to 107 inK of cafloln per kilo were employod in these experiments.] Rabbit 3S2. Bclgicin hare, female. Weight, 1,070 grains. Diet, oats. March 25: 8.5 cc 2 per cent caffein (158 mg per kilo) injected subculaneously at 2.15 p. m.; 4 p. in., reflexes increased; 5.45 p. m., increases of reflexes still more marked. March 2(;: Rabbit looked normal; no symptom.s observed. Rabbit.1^1. Belgian hare, female. Weight, 1,170 grams. Diet, oaLs. March 25: 2.15 p. m., 9 cc 2 per rout caffein (153 mg per kilo) injected subcutaneously; 4 p. m., reflexes increa.sed; 5.45 p. ni., condition the same. March 2(j: Rabbit looks normal; no symptoms observed. Rabbit 3JS. Belgian hare, female. Weight, 1,300 grams. Diet, oats. March 25: 9 cc 2 percent caffein injected subcutaneously (1-50 mg per kilo); 4 p. m., reflexes increased; 5.45 p. m., reflexes increased but not markedly. March 26: No symptoms; rabbit looks normal. Rabbit 322. White female. Weight, 1,065 grams. Diet, oats. March 17: 8 cc 2 per cent caffein (150 mg per kilo) injected subculaneoiisly at 11.55 a. m.; 12. .55 p. m., reflexes increased, but no tetanus nor any oilier...

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“…White female. Weight,1,714 grams. February 1: Autopsy: Cirrhosis of the liver; enteritis of small intestines; stomach and kidneys normal.…”

Section: Rabbit 69mentioning

confidence: 99%

Section: Effect Of Caffein On Renal Secretionmentioning

confidence: 99%

Section: Series Bmentioning

confidence: 99%

Section: Series Bmentioning

confidence: 99%

Section: Series Bmentioning

confidence: 99%