Stoichiometric and nonstoichiometric polyelectrolyte complex of chitosan and polyethyleneglycol‐monosuccinate: Preparation and characterization

Abstract

Stoichiometric and nonstoichiometric polyelectrolyte complex (PEC) was prepared with polyethylene glycol-monosuccinate (PEGMS), and chitosan (CS). A series of PEGMS were synthesized by a 1 : 1 mol ratio between PEG and succinic anhydride. Then, the novel PEC was prepared by a various mole reaction of the above synthesized PEGMS and CS. The physicochemical properties of the synthesized PEC was characterized by using elemental analysis, FTIR, 1 H, and 13 C nuclear magnetic resonance, dissolution behavior, and phase transition phenomenon. Furthermore, some properties of the PEC obtained were analyzed by UV-Visible spectrometry, wide-angle X-ray diffraction, differential scanning calorimeter, scanning electron microscope, and estimated solubility, and cell viability assay, respectively. It was found that the observed FTIR, 1 H, and 13 C-NMR data was in good agreement with the chemical structure of the prepared PEGMS and PEC. The dissolution behaviors of nonstoichiometric PEC were found to depend on the pH of the solution as well as on the PEGMS/CS composition. The study of MTT assay suggested that the viability of HepG2 human hepatoblastoma cell on PEC were increased significantly in accordance with mole ratio of CS. As the results, the obtained several product is a useful intermediate, which permits further chemical modification for the amino group of CS and may have potential applications in biocompatible or cosmetic systems.

Antibacterial activity of pH‐sensitive genipin cross‐linked chitosan/poly(ethylene glycol)/silver nanocomposites

“…The MTT assay showed fibroblasts cultured in contact with chitosan/PEG film. The biomaterial matrix with the low concentration of silver nanoparticles embedded in it had no significant differences from the result of chitosan/PEG in cytotoxicity 35–38…”

Solid-phase modification with succinic polyethyleneglycol of aminated lipase B from Candida antarctica: Effect of the immobilization protocol on enzyme catalytic properties

“…15 g of mPEG and 1 g of succinic anhydride (molar rate 1:1) were dissolved in 100 mL of CH 2 Cl 2 and 1.3 mL of triethylamine were added [8,45]. The reaction was stirred at 25 • C for 20 h. After that, the solvent was removed by evaporation in a rotavapor.…”

Preparation, characterization, and swelling and drug release properties of a crosslinked chitosan‐polycaprolactone gel

“…Recently extensive work is published using chitosan and other biocompatible polymeric materials to produce scaffolds for tissue engineering and to use these materials as a potential carrier for drug release 26–34. Some of these materials were prepared as blends of chitosan and PCL, chitosan and poly ( L ‐lactide), or poly( L ‐lactic acid), chitosan, and wollastonite 27–30. As chitosan is soluble in aqueous media it is difficult to interrelate the cell‐growth or drug‐release activities of these biomaterials to chitosan or the other blending substances.…”