Strain differences in morphine-withdrawal-induced aggression in rats

Borgen, Lowell A.; Khalsa, Jag H.; King, W. T.; Davis, William S.

doi:10.3758/bf03332422

Cited by 11 publications

(5 citation statements)

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“…We again observed a pronounced stretching movement, wi th apparent hindleg weakness, similar to the "writhing" noted in rats and mice after intraperitoneal administration of irritating and 14 pain-producing substances, as reported earlier (Borgen, Khalsa, King, & Davis, 1970). Also present, although not previously reported und er these conditions, was mounting activity by male Ss toward other males of the group, seen especialIy in the LE strain.…”

supporting

confidence: 58%

“…1), in contrast to the results of an earlier study (Borgen, Khalsa, King, & Davis, 1970), may be attributable to a strain-age interaction. Our earlier study (confirmed by additional data he re reported ), which showed that Long-Evans male rats were more aggressive than Sprague-Dawleys, was conducted with Ss at 45-47 days of age.…”

contrasting

confidence: 56%

“…We have reported a significant variation between three strains of rats (Sprague-Dawley, Long-Evans, and Wistar) in the degree of aggressive response induced by morphine withdrawal (Borgen, Khalsa, King, & Davis, 1970). The present work was conducted to determine the influence of several other factors, such as sex, age, group size, season, and time of day, on aggression associated with morphine withdrawal.…”

mentioning

confidence: 99%

“…Aggressive behavior began between 30 and 40 h of withdrawal for the SD strain and between 60 and 70 h for the LE strain. In each strain, the behavior las ted about 40 h. Data of the earlier study (Borgen, Khalsa, King, & Davis, 1970) and from these experiments bearing on the age and strain factors are combined in Table 1.…”

mentioning

confidence: 99%

“…A constant injection volume of 1.0 ml solution/200 g body weight was used throughout. After the 15-day injection period, the Ss were observed as described earlier (Borgen, Khalsa, King, & Davis, 1970). Briefly, an aggressive response was recorded only when at least two Ss assumed an upright fighting posture, facing each other, and a biting attack with vocalization occurred.…”

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confidence: 99%

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Some determinants of aggressive behavior induced by lnorphine withdrawal

Davis

Khalsa

1971

Psychon Sci

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Male and female rats of Sprague-Dawley and Long-Evans strains were given ,.1";1,, int.l"~neritoneal iniections of morphine sulfate in increasing dosage over a 15-day period to a terminal dose of 405 mg/kg/day. During withdrawal, fighting behavior occurred equally among older male rats (60 days at start of experiment) of both strains, housed in groups of six, but not at all in younger ones (30 days). Astrain difference found earlier in 45-day-old rats was confirmed. Females of either strain or age showed no aggressive behavior during withdrawal. Decreasing available cage space increased the number of aggressive , encounters, despite a reduction of group size to four. Saline-injected males of either strain rarely displayed aggression. A circadian rhythmicity of such behavior was not found. There was evidence for a seasonal variation in frequency of morphine-withdrawal-induced aggression, levels being higher in summer than in winter.

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supporting

confidence: 58%

contrasting

confidence: 56%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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