Strain differences to the effects of aversive frequency ultrasound on behaviour and brain topography of c-fos expression in the rat

Neophytou, Savvas Ioannou; Graham, M. Dean; Williams, Jessica; Aspley, Sue; Marsden, C.A.; Beckett, Simon

doi:10.1016/s0006-8993(99)02334-3

Cited by 39 publications

(30 citation statements)

References 44 publications

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“…In addition, we observed that ultrasound application has no effect on plasma corticosterone level, which is also true for cortisol levels in humans following a panic attack (Graeff 2007). Finally, we confirmed the finding of Neophytou et al (2000) that ultrasound induces c-Fos expression in the dorsal regions of the PAG and the amygdala, two regions frequently associated with human panic disorder (reviewed in Graeff and Del-Ben 2008), and demonstrated that these expressions were differentially modulated by the anxiolytic with panicolytic properties diazepam and the preclinical anxiolytic Ro 64-6198. The observed increases in heart rate and core body temperature are known autonomic symptoms of human panic attacks (Freedman et al 1984;Cameron et al 1987;DSM IV 2003) and animal panic reactions (Gray and McNaughton 2000).…”

Section: Discussionsupporting

confidence: 85%

“…Interestingly, ultrasoundinduced defensive behaviors correlated with increased c-Fos expression in the dorsal regions of the PAG, the amygdala, and in thalamic and hypothalamic nuclei, i.e. brain areas associated with aversive behaviors (Neophytou et al 2000).…”

Section: Introductionmentioning

confidence: 97%

“…Rats use 22-kHz ultrasonic vocalizations as alarm calls, and it has been previously shown that such alarm calls can induce defensive behaviors in conspecifics (Blanchard et al 1991;Brudzynski and Chiu 1995). Accordingly, Beckett et al (1996Beckett et al ( , 1997 observed that applying artificial 22-kHz ultrasounds at intensities of at least 65 dB induced escape and freezing behaviors in LH, but not in Wistar rats, which showed only increased freezing behavior (Beckett et al 1996;Neophytou et al 2000). Interestingly, ultrasoundinduced defensive behaviors correlated with increased c-Fos expression in the dorsal regions of the PAG, the amygdala, and in thalamic and hypothalamic nuclei, i.e.…”

Section: Introductionmentioning

confidence: 99%

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Examining face and construct validity of a noninvasive model of panic disorder in Lister-hooded rats

et al. 2010

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Similar to human panic attacks, ultrasound application to LH rats activated the autonomic, but not the neuroendocrine, stress system. Also, like in humans, the current data confirm and extend that the dPAG/dlPAG plays a key role in ultrasound-induced escape behavior. These observations suggest that ultrasound-induced escape behaviors in LH rats have face and construct validity for panic disorders.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Examining face and construct validity of a noninvasive model of panic disorder in Lister-hooded rats

et al. 2010

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“…Dependent on the strain of the receiver, 22-kHz calls can induce behavioral inhibition [48][49][50][51], or bursts of locomotor running and jumping, which are characteristic of defence behavior [49,50,52,53]. However, it has to be noted that studies using natural 22-kHz calls obtained only a moderate reduction of locomotor activity [48,51,59], which is in line with the relatively weak effects of 22-kHz calls found here.…”

Section: Playback Of 22-khz Calls Induce Behavioral Inhibitionsupporting

confidence: 86%

“…In adult rats, it was shown that the presentation of natural 22-kHz calls or 20-kHz sine wave tones can activate the fight/flight/freeze system [48][49][50][51][52][53]. However, little is known about the effects of 50-kHz calls on the behavior of the receiver.…”

Section: Introductionmentioning

confidence: 99%

Social Transmission of Avoidance Behavior Under Situational Change in Learned and Unlearned Rats

2016

Animal Behavior

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Rats emit distinct types of ultrasonic vocalizations, which differ depending on age, the subject's current state and environmental factors. Since it was shown that 50-kHz calls can serve as indices of the animal's positive subjective state, they have received increasing experimental attention, and have successfully been used to study neurobiological mechanisms of positive affect. However, it is likely that such calls do not only reflect a positive affective state, but that they also serve a communicative purpose. Actually, rats emit the highest rates of 50-kHz calls typically during social interactions, like reproductive behavior, juvenile play and tickling. Furthermore, it was recently shown that rats emit 50-kHz calls after separation from conspecifics. The aim of the present study was to test the communicative value of such 50-kHz calls. In a first experiment, conducted in juvenile rats situated singly on a radial maze apparatus, we showed that 50-kHz calls can induce behavioral activation and approach responses, which were selective to 50-kHz signals, since presentation of 22-kHz calls, considered to be aversive or threat signals, led to behavioral inhibition. In two other experiments, we used either natural 50-kHz calls, which had been previously recorded from other rats, or artificial sine wave stimuli, which were identical to these calls with respect to peak frequency, call length and temporal appearance. These signals were presented to either juvenile (Exp. 2) or adult (Exp. 3) male rats. Our data clearly show that 50-kHz signals can induce approach behavior, an effect, which was more pronounced in juvenile rats and which was not selective to natural calls, especially in adult rats. The recipient rats also emitted some 50-kHz calls in response to call presentation, but this effect was observed only in adult subjects. Together, our data show that 50-kHz calls can serve communicative purposes, namely as a social signal, which increases the likelihood of approach in the recipient conspecific.

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Call‐specific patterns of neural activation in auditory processing of Richardson’s ground squirrel alarm calls

2020

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Strain differences to the effects of aversive frequency ultrasound on behaviour and brain topography of c-fos expression in the rat

Cited by 39 publications

References 44 publications

Examining face and construct validity of a noninvasive model of panic disorder in Lister-hooded rats

Examining face and construct validity of a noninvasive model of panic disorder in Lister-hooded rats

Social Transmission of Avoidance Behavior Under Situational Change in Learned and Unlearned Rats

Call‐specific patterns of neural activation in auditory processing of Richardson’s ground squirrel alarm calls

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