Innovation is necessary for all industries' growth and sustainability, including the pharmaceutical sector. The study has focused on the pharmaceutical sector of Karachi to examine the impact of product, process, marketing, and organizational innovations on firm performance. It also examined the moderating role of environmental turbulence. The study collected a sample of 423 employees from the target firms. We found: "product innovation, process innovation, marketing innovation, and organizational innovation positively affect firm performance." We also found that (i) environmental turbulence moderates product innovation and firm performance, and (ii) environmental turbulence insignificantly moderates process innovation and firm performance. Past studies exhibit that innovation impacts business performance differently due to intensive competitive markets and environmental influence. Thus, to achieve high business performance, firms must focus on all the dimensions of innovation (i.e., product, process, marketing, and organization). Environmental turbulence, directly and indirectly, affects firm performance. Therefore, firms must deal with it adequately.