Strategies for Modified Release Oral Formulation Development

Sivert, Aurélien; Wald, Randy; Craig, Christopher; Benameur, Hassan

doi:10.1002/9781119772729.ch13

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…At the same time, natural polymers created without using genetically modified organisms (GMOs) and preservatives are being sought [3,7]. There is also a growing demand for new materials in terms of functionality, enabling the dosage form to be delayed, prolonged, or pulsed release [8,9]. In addition, with the development of the administration of locally acting drugs (e.g., for the treatment of Crohn's disease or colorectal cancer) or probiotics, polymers have been used to protect the dosage forms and their contents as they pass through the gastrointestinal tract (GIT) to its distal parts [10,11].…”

Section: Introductionmentioning

confidence: 99%

Commercially Available Enteric Empty Hard Capsules, Production Technology and Application

2022

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Currently, there is a growing need to prepare small batches of enteric capsules for individual therapy or clinical evaluation since many acidic-sensitive substances should be protected from the stomach’s acidic environment, including probiotics or fecal material, in the fecal microbiota transplantation (FMT) process. A suitable method seems to be the encapsulation of drugs or lyophilized alternatively frozen biological suspensions in commercial hard enteric capsules prepared by so-called Enteric Capsule Drug Delivery Technology (ECDDT). Manufacturers supply these types of capsules, made from pH-soluble polymers, in products such as AR Caps®, EnTRinsicTM, and Vcaps® Enteric, or capsules made of gelling polymers that release their content as the gel erodes over time when passing through the digestive tract. These include DRcaps®, EMBO CAPS® AP, BioVXR®, or ACGcaps™ HD. Although not all capsules in all formulations meet pharmaceutical requirements for delayed-release dosage forms in disintegration and dissolution tests, they usually find practical application. This literature review presents their composition and properties. Since ECDDT is a new technology, this article is based on a limited number of references.

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Section: Introductionmentioning

confidence: 99%