Strategies for re-vascularization and promotion of angiogenesis in trauma and disease

Gonçalves, Raquel Calvo; Banfi, Andrea; Oliveira, Mariana B.

doi:10.1016/j.biomaterials.2020.120628

Cited by 49 publications

(31 citation statements)

References 224 publications

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“…Tumor development, invasion and metastasis are highly dependent on neovascularization ( Goncalves et al, 2021 ; Rimini and Casadei-Gardini, 2021 ). Under physiological conditions, angiogenesis is intricately and precisely regulated by multiple molecules and mechanisms that allow the formation of highly tissue-specific, structured and hierarchical vascular networks to sustain the physiological processes of embryonic development, growth and tissue repair ( Lai et al, 2021 ; Martin and Gurevich, 2021 ; Narasimhan et al, 2021 ).…”

Section: Biological Function and Molecular Mechanism Of Circular Rnas In Glioblastomamentioning

confidence: 99%

Research Progress of circRNAs in Glioblastoma

Guo

Piao

2021

Front. Cell Dev. Biol.

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Circular RNAs (circRNAs) are a class of single-stranded covalently closed non-coding RNAs without a 5′ cap structure or 3′ terminal poly (A) tail, which are expressed in a variety of tissues and cells with conserved, stable and specific characteristics. Glioblastoma (GBM) is the most aggressive and lethal tumor in the central nervous system, characterized by high recurrence and mortality rates. The specific expression of circRNAs in GBM has demonstrated their potential to become new biomarkers for the development of GBM. The specific expression of circRNAs in GBM has shown their potential as new biomarkers for GBM cell proliferation, apoptosis, migration and invasion, which provides new ideas for GBM treatment. In this paper, we will review the biological properties and functions of circRNAs and their biological roles and clinical applications in GBM.

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Section: Biological Function and Molecular Mechanism Of Circular Rnas In Glioblastomamentioning

confidence: 99%

Research Progress of circRNAs in Glioblastoma

Guo

Piao

2021

Front. Cell Dev. Biol.

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“…The treatment of occluded or damaged coronary arteries typically involves bypass surgery using autologous arteries and veins [ 2 ]. However, the clinical applications of autologous arteries and veins are limited due to lack of availability, often complicated by pre-existing disease and size mismatches in a sizeable percentage of patients [ [3] , [4] , [5] , [6] ]. Hence, vascular substitutes constructed from synthetic biodegradable polyesters have emerged as a burgeoning research field in recent years.…”

Section: Introductionmentioning

confidence: 99%

Anti-Sca-1 antibody-functionalized vascular grafts improve vascular regeneration via selective capture of endogenous vascular stem/progenitor cells

Xing

Deng

et al. 2022

Bioactive Materials

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“…Blood vessels, especially the capillaries, run throughout the body, providing oxygen and nutrients and exchanging cellular and tissue byproducts to maintain normal functioning of tissues ( 1 ). However, insufficient vascularization causes impaired healing of fractures and placental deficiency, whereas increased vascularization leads to atherosclerosis, hemangioma, and neoplastic development ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

STAT6 Upregulates NRP1 Expression in Endothelial Cells and Promotes Angiogenesis

et al. 2022

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The role of signal transducer and activator of transcription 6 (STAT6) in tumor growth has been widely recognized. However, its effects on the regulation of angiogenesis remain unclear. In this study, we found that STAT6 promoted angiogenesis, possibly by increasing the expression of neuropilin-1 (NRP1) in endothelial cells (ECs). Both STAT6 inhibitor (AS1517499) and STAT6 siRNA reduced EC proliferation, migration, and tube-formation, accompanied by downregulation of NRP1, an angiogenesis regulator. Furthermore, IL-13 induced activation of STAT6 and then increased NRP1 expression in ECs. IL-13-induced EC migration and tube formation were inhibited by NRP1 siRNA. Luciferase assay and chromatin immunoprecipitation assay demonstrated that STAT6 could directly bind to human NRP1 promoter and increase the promoter activity. In tumor xenograft models, inhibition of STAT6 reduced xenograft growth, tumor angiogenesis, and NRP1 expression in vivo. Overall, these results clarified the novel mechanism by which STAT6 regulates angiogenesis, and suggested that STAT6 may be a potential target for anti-angiogenesis therapy.

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Strategies for re-vascularization and promotion of angiogenesis in trauma and disease

Cited by 49 publications

References 224 publications

Research Progress of circRNAs in Glioblastoma

Research Progress of circRNAs in Glioblastoma

Anti-Sca-1 antibody-functionalized vascular grafts improve vascular regeneration via selective capture of endogenous vascular stem/progenitor cells

STAT6 Upregulates NRP1 Expression in Endothelial Cells and Promotes Angiogenesis

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