Despite the difficulties, entrepreneurship met the socioeconomic challenges by providing solutions to rural areas during the COVID‐19 crisis, while healthcare entrepreneurial activity has been adapted to the changing conditions. The Greek rural areas' healthcare enterprises suffer the consequences of the public policies on COVID‐19 as their activities have been affected, their turnover has decreased, and liquidity problems have arisen. Entrepreneurs believe that the announced state and European support will help them overcome the implications. However, some of the support measures that have a loan rational will bring enterprises with bank loans to a halt. Indeed, entrepreneurship in rural areas faces multiple problems that they are trying to overcome during the COVID‐19 crisis. Uncertainty, insecurity and health scare prevailed. Despite the problems, the enterprises showed resilience and did not cease their operations.