Strategies to Explore Biomedical Application of Nanocellulose

Zhang, Yanjie; Chang, Peter R.; Ma, Xiaozhou; Lin, Ning; Huang, Jin

doi:10.1002/9783527807437.ch11

Cited by 6 publications

(3 citation statements)

References 173 publications

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“…4), thus replacing conventional petroleum-based materials (Dufresne 2019;Tibolla et al 2014). Nanocellulose, as a new environmental friendly material, has been incorporated into many types of materials, in both pure and composite forms and holds promise in many different applications, such as composite biomaterials (Sheikhi 2019;Shoseyov et al 2019), in energy storage systems (Kim et al 2019;Zhu et al 2016), in gas field drilling and cementing applications (Balea et al 2019;Ramasamy and Amanullah 2019), in textiles (Salah 2013), in functional packaging (Bras and Saini 2017), as drug delivery systems (Sheikhi et al 2019) and in biomedicine (Gatenholm and Klemm 2010;Lin and Dufresne 2014;Zhang et al 2019), in food industry, paper and boards, packaging, environmental protection and improvement, pharmaceuticals and healthcare (Abitbol et al 2016;Gotta et al 2018;Islam and Rahman 2019;Kargarzadeh et al 2017;Pachuau 2017;Thomas et al 2018). There are recent reviews reporting in further detail the applications of nanocelluloses (Abitbol et al 2016;Grishkewich et al 2017;Mondal 2017;Tayeb et al 2018).…”

Section: Different Forms Of Cellulose Nanomaterials and Applicationsmentioning

confidence: 99%

On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models

et al. 2020

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The need for reaching environmental sustainability encourages research on new cellulosebased materials for a broad range of applications across many sectors of industry. Cellulosic nanomaterials obtained from different sources and with different functionalization are being developed with the purpose of its use in many applications, in pure and composite forms, from consumer products to pharmaceutics and healthcare products. Based on previous knowledge about the possible adverse health effects of other nanomaterials with high aspect ratio and biopersistency in body fluids, e.g., carbon nanotubes, it is expected that the nanometric size of nanocellulose will increase its toxicity as compared to that of bulk cellulose. Several toxicological studies have been performed, in vitro or in vivo, with the aim of predicting the health effects caused by exposure to nanocellulose. Ultimately, their goal is to reduce the risk to humans associated with unintentional environmental or occupational exposure, and the design of safe nanocellulose materials to be used, e.g., as carriers for drug delivery or other biomedical applications, as in wound dressing materials. This review intends to identify the toxicological effects that are elicited by nanocelluloses produced through a topdown approach from vegetal biomass, namely, cellulose nanocrystals and nanofibrils, and relate them with the physicochemical characteristics of nanocellulose. For this purpose, the article provides: (i) a brief review of the types and applications of cellulose nanomaterials; (ii) a comprehensive review of the literature reporting their biological impact, alongside to their specific physicochemical characteristics, in order to draw conclusions about their effects on human health.Célia Ventura and Fátima Pinto have contributed equally to this work.

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Section: Different Forms Of Cellulose Nanomaterials and Applicationsmentioning

confidence: 99%

On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models

et al. 2020

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“…In this process there is restoration and proliferation of the damaged or diseased cells. Nanocellulose is a non-toxic source that can be utilized for tissue engineering [60]. Scaffolds are crucial in all types of tissue engineering.…”

Section: Figurementioning

confidence: 99%

Lignocellulose Derived Nanocellulose, Its Properties, and Applications - A Review

Samrot

Arif

Kasipandian

2023

ijmst

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Natural fibers are abundant in natural resources. Natural fibers have been used in various applications. Natural fibers have been proved to be extremely useful in multiple fields in the world. Natural fibers possess great mechanical and optical properties. Nanocellulose fibers are obtained from plants and it has many applications. It can be used as a nanocomposite. They can be extracted by performing various techniques. It is used as a barrier due to its crystalline structure, which makes it difficult for molecules to flow through. Nanocellulose fibers are biodegradable, strong, lightweight, low density, and renewable since they have been produced from natural resources. They have immense applications in electricals, nanotechnology, medicine, drug delivery, aerospace, adsorbents, papermaking, and dental. The following review will focus on the properties of lignocellulose-derived nanocellulose, cellulose nanocrystals (CNCs), and cellulose nanofibrils (CNFs) and their applications in nanotechnology.

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“…Within the biomedical field, applications of nanocellulose are numerous and progress has been increasingly visible [ 3 , 4 , 5 , 6 ]. Since micro/nanocelluloses are considered biocompatible, several investigations have been made regarding their use in areas such as wound healing [ 7 , 8 , 9 , 10 ], surgical suturing [ 11 ] and regenerative medicine, for instance, as a matrix for bone regeneration, scaffolds for tissue-engineered meniscus, blood vessels, ligaments or tendons [ 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity of Three Micro/Nanocelluloses with Different Physicochemical Characteristics in MG-63 and V79 Cells

Ventura

Marques

Cadete

et al. 2022

JoX

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(1) Background: Nanocellulose is an innovative engineered nanomaterial with an enormous potential for use in a wide array of industrial and biomedical applications and with fast growing economic value. The expanding production of nanocellulose is leading to an increased human exposure, raising concerns about their potential health effects. This study was aimed at assessing the potential toxic and genotoxic effects of different nanocelluloses in two mammalian cell lines; (2) Methods: Two micro/nanocelluloses, produced with a TEMPO oxidation pre-treatment (CNFs) and an enzymatic pre-treatment (CMFs), and cellulose nanocrystals (CNCs) were tested in osteoblastic-like human cells (MG-63) and Chinese hamster lung fibroblasts (V79) using the MTT and clonogenic assays to analyse cytotoxicity, and the micronucleus assay to test genotoxicity; (3) Results: cytotoxicity was observed by the clonogenic assay in V79 cells, particularly for CNCs, but not by the MTT assay; CNF induced micronuclei in both cell lines and nucleoplasmic bridges in MG-63 cells; CMF and CNC induced micronuclei and nucleoplasmic bridges in MG-63 cells, but not in V79 cells; (4) Conclusions: All nanocelluloses revealed cytotoxicity and genotoxicity, although at different concentrations, that may be related to their physicochemical differences and availability for cell uptake, and to differences in the DNA damage response of the cell model.

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Strategies to Explore Biomedical Application of Nanocellulose

Cited by 6 publications

References 173 publications

On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models

On the toxicity of cellulose nanocrystals and nanofibrils in animal and cellular models

Lignocellulose Derived Nanocellulose, Its Properties, and Applications - A Review

Genotoxicity of Three Micro/Nanocelluloses with Different Physicochemical Characteristics in MG-63 and V79 Cells

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