Background. Weather-related disasters such as droughts and fires as accelerated by climate change have led to substantial growth in interest in impacted health outcomes. While physical health outcomes have been studied in this context, our understanding of climate change impacted mental health is at its infancy. This study focuses on the mental health impacts of the largest Californian wildfire to-date, the Camp Fire of 2018.Methods. We investigated a sample of 780 Californian residents with different degrees of disaster exposure, and measured mental health using clinically valid scales for post-traumatic stress disorder (PTSD), major depressive disorder (MDD), and generalized anxiety disorder (GAD); data were collected six months post-exposure to understand sustained chronic impacts. Data were modeled using multiple-regression analyses. Additionally, we included vulnerability and resilience factors in hierarchical regression analyses.Results. Our primary finding is that direct exposure to large scale fires significantly increased the risk for all three mental health disorders, PTSD, MDD and GAD. Indirect exposure, for those who witnessed but did not personally experience the fires, increased the risk for MDD and GAD. Inclusion of vulnerability and resilience factors led to significantly improved prediction of all mental health outcomes. Low socio-economic status, childhood trauma and sleep disturbances were identified as vulnerability factors, while self-reported resilience had a positive effect on mental health. Mindfulness was associated with lower MDD and GAD symptom scores.Conclusion. Overall, our study demonstrates that climate-related extremes such as fires severely impact long-term mental wellbeing. Additionally, pre-existing adverse life events, resilient personality traits and lifestyle factors play an important role in the development of psychopathology after such disasters. Unchecked climate changes of magnitude projected for the latter half of this century risk severely impacting the mental wellbeing of the global population.