Streptococcus canis infections in humans: Retrospective study of 54 patients

Galpérine, Tatiana; Cazorla, C.; Blanchard, Élodie; Boineau, F.; Ragnaud, Jean‐Marie; Néau, Didier

doi:10.1016/j.jinf.2006.12.013

Cited by 79 publications

(86 citation statements)

References 17 publications

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“…5A). The two larger PFGE clusters identified, H 25 and B 20 , correlated with the two most frequent STs, as they grouped mainly ST13 (n ϭ 13) and ST9 (n ϭ 17) isolates. Table 2 shows the distribution of STs in the various PFGE clusters.…”

Section: Phenotypic and Genotypic Identification Of S Canis Isolatesmentioning

confidence: 90%

“…canis, a widely distributed house pet colonizer and pathogen, is increasingly being reported in human infection (20,21,23). In industrialized countries, a trend toward closer contact and increased cohabitation in households with traditional pets such as dogs and cats has been noted (42,43), making transmission of microorganisms between house pets and humans more likely to occur.…”

Section: Discussionmentioning

confidence: 99%

“…Most PFGE clusters included more than one ST, and in some cases, the same ST was found among diverse PFGE clusters, resulting in an overall low level of association between the two typing techniques, as given by an AW coefficient between PFGE clusters and STs (AW PFGE¡ST ) of 0.364 (95% CI, 0.224 to 0.505) and an AW ST¡P -FGE of 0.537 (95% CI, 0.368 to 0.706). The overall correspondence between PFGE cluster and CCs was significantly higher when CCs (2) NT (2) Dog (1), human (1) 17 (2) 13 13 H 25 (2) NT (2) Dog (2) 11 (2) 11 13 H 25 (2) NT (2) Dog (2) 8 (1) 11 13 H 25 (1) NT (1) Dog (1) 2 (3) 2 2 J 6 (2), I 2 (1) NT (3) Dog (3) 6 (1) 2 2 J 6 (1) NT (1) Dog (1) 7 (1) 2 2 J 6 (1) NT (1) Dog (1) 18 (2) 2 2 J 6 (2) NT (2) Dog (2) 1 (11) 1 1 A 5 (5), E 2 (2), F 2 (2), B 20 (1), up (1) stG1389 (11) Dog (11) 24 (1) 1 (4) 15 (1) S 21 H 25 (1) NT (1) Dog (1) 20 (1) S 21…”

Section: Phenotypic and Genotypic Identification Of S Canis Isolatesmentioning

confidence: 99%

“…The first confirmed report of human infection was published in 1997 and consisted of a case of septicemia in a 77-yearold man (18). In the last few years, a better awareness of S. canis has led to an increasing number of reports in the literature (19)(20)(21)(22)(23). S. canis has mainly been isolated from cases of bacteremia (18,19,23) and skin and soft tissue infections (20,21).…”

mentioning

confidence: 99%

“…In the last few years, a better awareness of S. canis has led to an increasing number of reports in the literature (19)(20)(21)(22)(23). S. canis has mainly been isolated from cases of bacteremia (18,19,23) and skin and soft tissue infections (20,21). Some of these studies indicated that contact of pets with patients' wounds and ulcers would be the most likely portal of entry (18,21), and one report identified the same S. canis strain in a dog and its owner's blood cultures following a bite (22).…”

mentioning

confidence: 99%

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Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp.equisimilis

Pinho

Matos

Pomba³

et al. 2013

J Clin Microbiol

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dStreptococcus canis is an animal pathogen that occasionally causes human infections. Isolates recovered from infections of animals (n ‫؍‬ 78, recovered from 2000 to 2010 in three European countries, mainly from house pets) and humans (n ‫؍‬ 7, recovered from 2006 to 2010 in Portugal) were identified by phenotypic and genotypic methods and characterized by antimicrobial susceptibility testing, multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE), and emm typing. S. canis isolates presented considerable variability in biochemical profiles and 16S rRNA. Resistance to antimicrobial agents was low, with the most significant being tet(M)-and tet(O)-mediated tetracycline resistance. MLST analysis revealed a polyclonal structure of the S. canis population causing infections, where the same genetic lineages were found infecting house pets and humans and were disseminated in distinct geographic locations. Phylogenetic analysis indicated that S. canis was a divergent taxon of the sister species Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis and found evidence of acquisition of genetic material by S. canis from S. dysgalactiae subsp. equisimilis. PFGE confirmed the MLST findings, further strengthening the similarity between animal and human isolates. The presence of emm-like genes was restricted to a few isolates and correlated with some MLST-based genetic lineages, but none of the human isolates could be emm typed. Our data show that S. canis isolates recovered from house pets and humans constitute a single population and demonstrate that isolates belonging to the main genetic lineages identified have the ability to infect the human host, providing strong evidence for the zoonotic nature of S. canis infection.

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Section: Phenotypic and Genotypic Identification Of S Canis Isolatesmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Phenotypic and Genotypic Identification Of S Canis Isolatesmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp.equisimilis

Pinho

Matos

Pomba³

et al. 2013

J Clin Microbiol

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Bacterial Diseases

Weese

BSc

2010

Companion Animal Zoonoses

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Human pathogenic streptococcal proteomics and vaccine development

Cole

Henningham

Gillen

et al. 2008

Proteomics Clinical Apps

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Gram-positive streptococci are non-motile, chain-forming bacteria commonly found in the normal oral and bowel flora of warm-blooded animals. Over the past decade, a proteomic approach combining 2-DE and MS has been used to systematically map the cellular, surface-associated and secreted proteins of human pathogenic streptococcal species. The public availability of complete streptococcal genomic sequences and the amalgamation of proteomic, genomic and bioinformatic technologies have recently facilitated the identification of novel streptococcal vaccine candidate antigens and therapeutic agents. The objective of this review is to examine the constituents of the streptococcal cell wall and secreted proteome, the mechanisms of transport of surface and secreted proteins, and describe the current methodologies employed for the identification of novel surface-displayed proteins and potential vaccine antigens.

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Streptococcus canis infections in humans: Retrospective study of 54 patients

Cited by 79 publications

References 17 publications

Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp.equisimilis

Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp.equisimilis

Bacterial Diseases

Human pathogenic streptococcal proteomics and vaccine development

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