Streptococcus dentisani is a common inhabitant of the oral microbiota worldwide and is found at higher levels in caries-free individuals

López-Santacruz, Hiram Daniel; López‐López, Arantxa; Revilla-Guarinos, Ainhoa; Camelo-Castillo, Anny; Esparza-Villalpando, Vicente; Mira, Álex; Aranda‐Romo, Saray

doi:10.1007/s10123-021-00222-9

Cited by 11 publications

(10 citation statements)

References 46 publications

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“…dentisani increased [ 12 ]. Notably, the Streptococcus species that are increased in biofilms treated with Aii20J are all health-associated, and they have even been proposed as probiotics in the oral field [ 36 , 37 , 38 ]. In the present study, the probiotic potential of S. cristatus and S. salivarius derives from the expression of pH-buffering enzymes: arginine deiminase in S. cristatus [ 39 ] and urease in S. salivarius [ 2 ].…”

Section: Resultsmentioning

confidence: 99%

New Preventive Strategy against Oral Biofilm Formation in Caries-Active Children: An In Vitro Study

Parga,

Balboa,

Otero-Casal

et al. 2023

Antibiotics

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Quorum quenching (QQ) is the inhibition of bacterial communication, i.e., quorum sensing (QS). QS is a key mechanism in regulating biofilm formation and phenotype in complex bacterial communities, such as those found within cariogenic biofilms. Whereas QQ approaches were shown to effectively reduce biomass, knowledge of their impact on the taxonomic composition of oral polymicrobial biofilms remains scarce. Here, we investigate the effect of the QQ lactonase Aii20J on biomass production and taxonomical composition of biofilms. We collected supragingival plaque samples from 10 caries-free and 10 caries-active children and cultured them to generate in vitro biofilms. We describe significant biomass reductions upon Aii20J exposure, as assessed by crystal violet assays. Taxonomical profiling using 16S rRNA gene amplicon sequencing revealed no significant changes in bacterial composition at the genus level. Interestingly, at the species level Aii20J-treatment increased the abundance of Streptococcus cristatus and Streptococcus salivarius. Both S. cristatus and S. salivarius express pH-buffering enzymes (arginine deiminase and urease, respectively) that catalyze ammonia production, thereby potentially raising local pH and counteracting the biofilm’s cariogenic potential. Within the limitations of the study, our findings provide evidence of the biofilm-modulating ability of QQ and offer novel insights into alternative strategies to restore homeostasis within dysbiotic ecosystems.

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Section: Resultsmentioning

confidence: 99%

New Preventive Strategy against Oral Biofilm Formation in Caries-Active Children: An In Vitro Study

Parga,

Balboa,

Otero-Casal

et al. 2023

Antibiotics

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“…nov. 109 S. dentisani is detected in most dental plaque samples from caries-free individuals, has a global distribution and has been shown to not produce toxic secondary metabolites. 110 The bacteria has also been attributed a probiotic action, inhibiting the growth of certain oral pathogens by the action of bacteriocins and neutralizing the acidic pH. 111 A pilot clinical trial showed that S. dentisani temporarily colonizes the oral cavity and buffers the oral pH, especially after administering multiple doses.…”

Section: Streptococcus Dentisanimentioning

confidence: 99%

“…S. dentisani is detected in most dental plaque samples from caries‐free individuals, has a global distribution and has been shown to not produce toxic secondary metabolites 110 . The bacteria has also been attributed a probiotic action, inhibiting the growth of certain oral pathogens by the action of bacteriocins and neutralizing the acidic pH 111 .…”

Section: Streptococcus Spp With Potential Anti‐caries Inhibitory Acti...mentioning

confidence: 99%

Anti‐caries Streptococcus spp.: A potential preventive tool for special needs patients

Mato,

Montaño‐Barrientos,

Rivas‐Mundiña

et al. 2023

Special Care in Dentistry

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IntroductionProbiotics are living microorganisms that act on the host‐microbiome interface to restore the microbiota's physiological homeostasis. Numerous probiotics have been marketed with inhibitory activity against Streptococcus mutans and consequently with a potential anti‐caries effect, mainly of the genera Lactobacillus and Bifidobacterium, whose main disadvantage is their limited ability to settle in the oral cavity.MethodsThis narrative review describes the main Streptococcus spp. with probiotic anti‐Streptococcus mutans activity, whose substantivity is greater than that of Lactobacillus spp. and consequently with anti‐caries potentiality. We performed a literature review in the PubMed, Science Direct and Google Scholar databases of articles published in English (without time restriction) related to caries and probiotics.ResultsThe potential identified anti‐caries probiotics included Streptococcus spp. A12, Streptococcus oralis (AJ3), Streptococcus oligofermentans, Streptococcus salivarius (K12, M18, JH, LAB813, 24SMB), Streptococcus spp. with arginolytic activity (S. sanguinis, S. gordonii, S. ratti, S. parasanguinis, S. intermedius, S. australis, and S. cristatus), Streptococcus rattus (JH145), Streptococcus dentisani and Streptococcus downii.ConclusionsThe possibility of using these Streptococcus spp. as probiotics that inhibit the growth of dental plaque and the development of carious lesions represents a potential tool of particular interest for individuals with physical or intellectual disabilities that impede the routine and effective application of mechanical dental plaque removal techniques.

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“…Se indica que la bacteria S. dentisani está distribuida globalmente y en relación a su cantidad se presenta un mayor número en muestras de biopelículas dentales de niños sin caries (32) . Los resultados de un estudio realizado en Colombia, determinó su presencia en todas las muestras de niños entre 6 a 12 años de diferentes ciudades, evidenciando una posible relación con la salud bucal; por lo tanto, se busca la colonización del S. dentisani en la cavidad bucal, a través de pruebas clínicas (33) .…”

Section: El Dominio Del S Dentisani Como Probiótico Oralunclassified

Streptococcus dentisani una promesa de probiótico bucal. Revisión de literatura

Díaz Mayta,

Sernaque Calderon,

Roque Gallardo

et al. 2023

Rev. Soc. cient. Parag.

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El Streptococcus dentisani es una bacteria que ha llamado la atención de la comunidad científica en los últimos años por poseer capacidades muy prometedoras para restablecer el equilibrio de la microbiota bucal que conforma la biopelícula dental, manteniendo el pH cerca a la neutralidad evitando la acidificación y por consiguiente la propagación de bacterias cariogénicas, y periodontopatógenas; microorganismos involucrados en la disbiosis oral. En pruebas clínicas resaltan a la luz el aumento de saliva y amoniaco, disminución de la biopelícula dental de microorganismos cariogénicos, debido a la capacidad de liberar más de seis tipos de bacteriocinas que inhiben completamente al Streptococcus mutans, S sobrinus, S. salivarius y Prevotella intermedia. El objetivo de esta revisión es evidenciar las grandes capacidades como probiótico del Streptococcus dentisani para preservar la salud bucodental.

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Streptococcus dentisani is a common inhabitant of the oral microbiota worldwide and is found at higher levels in caries-free individuals

Cited by 11 publications

References 46 publications

New Preventive Strategy against Oral Biofilm Formation in Caries-Active Children: An In Vitro Study

New Preventive Strategy against Oral Biofilm Formation in Caries-Active Children: An In Vitro Study

Anti‐caries Streptococcus spp.: A potential preventive tool for special needs patients

Streptococcus dentisani una promesa de probiótico bucal. Revisión de literatura

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