Streptococcus Pneumoniæ Resistant to Penicillin and Chloramphenicol

Appelbaum, Peter C.; Scragg, J. N.; Bowen, AnnetteJ.; Bhamjee, A.; Hallett, A. F.; Cooper, R. Gavine

doi:10.1016/s0140-6736(77)92892-6

Cited by 291 publications

(105 citation statements)

References 16 publications

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“…The emergence of antibiotic resistant strains of pneumococci over the last 20 years, has made management of these infections more difficult [4]. Early resistant isolates showed intermediate levels of resistance to penicillin (minimum inhibitory concentration (MIC) 0n12-1 µg\ml) but later, highly resistant isolates (MIC 4-8 µg\ml) [5], and multiply-resistant pneumococci were reported [6]. Reports show a progressive increase in prevalence once resistant strains are introduced into an area, as observed in Spain between 1980 and 1987 [7,8].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of carriage of antimicrobial resistant strains of Streptococcus pneumoniae in primary school children in Hong Kong

Boost

O'Donoghue

Dooley³

2001

Epidemiol. Infect.

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SUMMARYA cross-sectional survey was conducted to determine prevalence and assess risk factors for carriage of antibiotic resistant strains of Streptococcus pneumoniae in healthy school children in Hong Kong. Throat swabs were collected from 1455 subjects and written questionnaires providing demographic data and medical history were completed by parents. The overall carriage rate of Streptococcus pneumoniae was 3n5 %, of which 49 % were penicillin resistant. High levels of resistance to tetracycline (73 %), erythromycin (52 %), trimethoprim (66 %) and ciprofloxacin (57 %) were observed. Carriage was associated with presence of a younger sibling (OR l 1n79) and use of antibiotics (OR l 2n31). High use of day care and small size of housing units did not result in a high rate of carriage. The low rate of carriage may be linked to high use of antibiotics, geographical factors or ethnicity. High rates of antibiotic resistance reflect heavy use of antibiotics by general practitioners.

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Section: Introductionmentioning

confidence: 99%

Prevalence of carriage of antimicrobial resistant strains of Streptococcus pneumoniae in primary school children in Hong Kong

Boost

O'Donoghue

Dooley³

2001

Epidemiol. Infect.

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“…As has often been pointed out, notably from Philadelphia by Austrian (Austrian & Gold, 1964; Austrian, 1968Austrian, , 1975Austrian, , 1977a and b), serious infections due to this species are still common and, particularly among some groups of patients, still have a high mortality rate. The recent emergence of pneumococcal strains resistant to penicillin and to other antibiotics (Hansman et al 1971;Appelbaum et al 1977) has emphasized the importance of a preventive rather than a purely therapeutic approach to pneumococcal infections. Since the * Present address: Public Health Laboratory, Northern General Hospital, Sheffield S5 7AU.…”

Section: Introduction and Methodsmentioning

confidence: 99%

Frequencies of pneumococcal types causing serious infections in patients admitted to the Radcliffe Infirmary, Oxford, 1969–77

Turk¹

1978

J. Hyg.

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SUM1IMARYDuring a 71 year period pneumococci were isolated from body fluids of 124 patients at the Radcliffe Infirmary, Oxford -72 with pneumonia, 26 with meningitis and 26 with other serious infections. Eighty-one (65 %) of the patients were over 50, and 33 (27 %) were over 70 years old. Of the 124 pneumococcal strains 104 (84 %), including 23 (79 %) of those from patients who died, belonged to types included in the vaccines successfully used in South Africa and in Papua New Guinea. The relative frequencies of types in the Oxford series and in a larger British series agreed closely with those found in a recent survey of 3644 bacteraemic pneumococcal infections in 10 American cities. Any polyvalent pneumococcal vaccine licensed for use in the United States is thus likely to be relevant to the situation in Britain.

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“…The similar strains became widespread in the world [4]. High-level penicillin-resistant pneumococci were reported in South Africa in 1977 [5]. This is the first report of penicillin resistance in Streptococcus pneumoniae isolated from respiratory sites in adults from Turkey.…”

Section: Resistance To Penicillin Among the Streptococcus Pneumoniae mentioning

confidence: 99%

Resistance to penicillin among theStreptococcus pneumoniaein Turkey

Yurdakul¹,

Çalişir²,

Atasever³

et al. 2001

Eur Respir J

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Streptococcus Pneumoniæ Resistant to Penicillin and Chloramphenicol

Cited by 291 publications

References 16 publications

Prevalence of carriage of antimicrobial resistant strains of Streptococcus pneumoniae in primary school children in Hong Kong

Prevalence of carriage of antimicrobial resistant strains of Streptococcus pneumoniae in primary school children in Hong Kong

Frequencies of pneumococcal types causing serious infections in patients admitted to the Radcliffe Infirmary, Oxford, 1969–77

Resistance to penicillin among theStreptococcus pneumoniaein Turkey

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