Streptozotocin-Induced Sporadic Alzheimer's Disease: Selection of Appropriate Dose

Mehla, Jogender; Pahuja, Monika; Gupta, Yogendra Kumar

doi:10.3233/jad-2012-120958

Cited by 91 publications

(57 citation statements)

References 23 publications

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“…SAD was induced in mice by intracerebroventricular (ICV) injection of STZ (3 mg/kg) dissolved in saline 40 . The detailed procedures can be reviewed in the Supplementary Information.…”

Section: Methodsmentioning

confidence: 99%

RETRACTED ARTICLE: Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a

El-Halawany

Sayed

Abdallah

et al. 2017

Sci Rep

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Gingerol is a major dietary compound that occurs in several plants belonging to the Zingiberaceae family. In the current study, the protective effect of gingerol on STZ-induced sporadic Alzheimer’s disease (SAD) was determined. Gingerol was isolated from the seeds of Aframomum melegueta K. Schum and tested at doses of 10 and 20 mg/kgbwt for its possible effect on the SAD model in mice, using celecoxib (30 mg/kg bwt) as a reference standard. The curative effects of gingerol were assessed through measurement of β-amyloid (Aβ-42), α-, β- secretases, APH1a and COX-2 levels. In addition, improvement in the cognitive deficit in mice after treatment was confirmed using the water maze and Y-maze with intra-maze cues. Gingerol improved the cognitive and behavioral impairment and AD-like pathology in streptozotocin model mice. These beneficial effects occurred with an increase in α-secretase activity and a decrease in cerebral Aβ-42, β- secretase, APH1a activity and COX-2-linked neuro-inflammation.

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“…SAD was induced in mice by intracerebroventricular (ICV) injection of STZ (3 mg/kg) dissolved in saline 40 . The detailed procedures can be reviewed in the Supplementary Information.…”

Section: Methodsmentioning

confidence: 99%

RETRACTED ARTICLE: Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a

El-Halawany

Sayed

Abdallah

et al. 2017

Sci Rep

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“…Many previous studies confirm our findings (Mehla et al 2013;Rai et al 2013). Intracerebroventricular injection of STZ at this dose led to significant defects in the memory of the animals (Rai et al 2013).…”

Section: Discussionsupporting

confidence: 81%

Effect of Cornus mas fruit flavonoids on memory retention, level of plasma glucose and lipids in an intracerebroventricular streptozotocin-induced experimental Alzheimer’s disease model in Wistar rats

Darbandi

Hashemi²,

Noori³

et al. 2016

EEB

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Poor nutrition, poor mobility, obesity and ageing increase the possibility of neuronal disorder and Alzheimer's disease. This study examined effect of Cornus mas flavonoids on memory retention and the level of plasma glucose and lipids in an intra-cerebroventricular streptozotocin-induced experimental Alzheimer's disease model in Wistar rats. Intracerebroventricular administration of streptozotocine (3 mg kg-1) was performed and the animals memory were evaluated through passive avoidance tasks. Five groups (saline-saline control, streptozotocine-saline, and streptozotocine with different flavonoid doses [5, 10, 20 mg kg -1 ]) were examined. Animals received different doses of C. mas flavonoids or saline for three weeks starting one day before surgery. Rat weight was measured at the beginning of each week. Injection of streptozotocine significantly reduced memory retention, compared to the control group. Flavonoid treatment increased memory retention in a dose-dependent manner, and triglyceride and glucose concentration decreased memory retention. At the same time, high-density lipoprotein concentration increased without any effect on low-density lipoprotein concentration. The dose of 10 mg kg -1 decreased rat weight significantly. Our findings show that C. mas flavonoids can optimize cognitive deficits caused by injections of streptozotocine and also have a few positive effects on reducing the risk factors in the serum.

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“…The animals were purchased from Slac Laboratory Animal Co Ltd (Shanghai, China). The rats in the first group (V) treated with vehicle did not have surgery because previous studies [14] and our results (Supplementary Figure S1A-S1B) both demonstrated that there was no significant difference in the behavior and cognitive function of control rats (without surgery) and that of sham rats (recipients of an ICV injection of vehicle). The rats in the second group (SV) were injected with ICV-STZ (3 mg/kg bilaterally) and vehicle, and the rats in the third (SL) and fourth (SH) groups were injected with ICV-STZ and different doses of LX2343 (7 and 21 mg/kg, respectively).…”

Section: Animal Experimentsmentioning

confidence: 94%

LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy

et al. 2017

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alzheimer's disease (aD) is a progressive neurodegenerative disease leading to the irreversible loss of brain neurons and cognitive abilities, and the vicious interplay between oxidative stress (OS) and tauopathy is believed to be one of the major players in aD development. Here, we demonstrated the capability of the small molecule N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (LX2343) to ameliorate the cognitive dysfunction of aD model rats by inhibiting OS-induced neuronal apoptosis and tauopathy. Streptozotocin (STZ) was used to induce OS in neuronal cells in vitro and in aD model rats that were made by intracerebroventricular injection of STZ (3 mg/kg, bilaterally), and Morris water maze test was used to evaluate the cognitive dysfunction in ICV-STZ rats. Treatment with LX2343 (5-20 μmol/L) significantly attenuated STZ-induced apoptosis in SH-SY5Y cells and mouse primary cortical neurons by alleviating OS and inhibiting the JNK/p38 and pro-apoptotic pathways. LX2343 was able to restore the integrity of mitochondrial function and morphology, increase aTP biosynthesis, and reduce ROS accumulation in the neuronal cells. In addition, LX2343 was found to be a non-ATP competitive GSK-3β inhibitor with IC 50 of 1.84±0.07 μmol/L, and it potently inhibited tau hyperphosphorylation in the neuronal cells. In ICV-STZ rats, administration of LX2343 (7, 21 mg·kg -1 ·d -1 , ip, for 5 weeks) efficiently improved their cognitive deficits. LX2343 ameliorates the cognitive dysfunction in the AD model rats by suppressing OS-induced neuronal apoptosis and tauopathy, thus highlighting the potential of LX2343 for the treatment of aD.

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Streptozotocin-Induced Sporadic Alzheimer's Disease: Selection of Appropriate Dose

Cited by 91 publications

References 23 publications

RETRACTED ARTICLE: Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a

RETRACTED ARTICLE: Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a

Effect of Cornus mas fruit flavonoids on memory retention, level of plasma glucose and lipids in an intracerebroventricular streptozotocin-induced experimental Alzheimer’s disease model in Wistar rats

LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy

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