Stress-Protective and Stress-Potentiating Effects of Antibodies to Glutamate and γ-Aminobutyric Acid after Intranasal Administration in C57Bl/6 Mice

Abstract

We studied the effects of antibodies to glutamate and GABA administered intranasally 1 h before and immediately after stress on the development of stress response in C57Bl/6 mice. Antibodies to glutamate administered 1 h before stress prevented the development of the stress-reaction judging from behavioral parameters in the open field test and hyperalgesia test, while antibodies to GABA potentiated the severity of stress-induced behavioral disorders: total behavioral activity in the open field decreased significantly. When administered after stress, antibodies to glutamate did not reduce, but exacerbated stress reaction; antibodies to GABA also exhibited a stress-potentiating effect.

Characteristics of Olfactory Epithelium and Manipulations of Neural Functions in the Brain by the Intranasal Administration

“…154 L-DOPA 17,19) 197 meptazinol 9) 233 lidocaine 10) 234 estradiol 37) 272 morphine 38) 285 testosterone 39) 288 cocaine 19) 303 a‰atoxin B 40,41) 312 progesterone 18) 314 pregnenolone 42) 316 GW468816 10) 380 GR138950 10) 405 GV196771 10) 412 GR138950 8) 493 Mouse GABA 103 dopamine 8) 154 rotenone 394 Gilt androstenol 43) 274 Molecules (high MW) Rat orexin-A 44) 3561 human b-amyloid 27) 4615 IGF-I 21,45) 7649 leptin 22,46) 16000 interferon-b 47) 22500 Mouse human b-amyloid 4615 NGF 48) 13000 leptin 16000 anti-Glu antibody 26) anti-GABA antibody 26) Monkey orexin-A 28) 3561 interferon-b 49) 22500 Human orexin-A 31) 3561 vasopressin 29) 1056 insulin 33 35) 5808 melanocortin (MSH) 30 …”