IntroductionIn recent years, Personalized, Predictive, Preventive, and Participatory healthcare have become more than just buzzwords. Silicon is playing an important enabling role in this gradual, but certain revolution of our healthcare system: Silicon will become more essential, in view of the many challenges in realizing ubiquitous monitoring, real-time diagnostics, and patient-centric therapies. By reviewing world-wide technology breakthroughs, as well as healthcarerelated trials with wireless sensors in Body-Area-Network (BAN) configurations, we will demonstrate that application validation for personal diagnostics and theranostic products is driving game-changing circuit and system innovation. Visionary applications such as brain-computer interfaces sound like magic! However, with every new generation of technology and application algorithms, wearable wireless systems become less obtrusive, higher performing, and more autonomous. The envisaged large-scale deployment of wearable healthcare and lifestyle add-ons that can monitor systemic factors such as stress and emotions, will revolutionize how we live, play, and work. But, none of these developments is heralding a "Brave New World"; instead, they will foster and strengthen the role and impact of each individual along the path to a longer, healthier and happier life.
"How are you?"2.1 Self-Reported Information Christine, one of the 21,500 Multiple Sclerosis (MS) patients that share selfreported health data on the web (www.patientslikeme.com, Fig. 1.2.1), evaluates her condition this week with a score of 71 on this site's MS rating scale. She shares the type and frequency of the prescription medication she took over the past years and the evolution of the primary symptoms like anxiety, bladder and bowel problems, brain fog, depression, emotional lability, excessive daytime sleepiness, general fatigue, mood swings, pain, sexual dysfunction, and stiffness or spasticity. No fewer than 40 secondary symptoms are scored further down the list. Except for evaluation of heart rate, blood pressure, temperature and weight, very few of these assessments are by direct measurement. Also, the data are not taken by trained medical staff and the time and duration of observation is highly variable. From a strict medical viewpoint, questions can be posed concerning the validity of this type of Internet "service" but patients clearly see the benefit, as do the pharmaceutical companies, seeking direct feedback and subjects for clinical trials. Without doubt, this information is more complete and precisely logged than that provided in the private setting of a doctor's practice, concerning recently developed symptoms or feedback on health-related quality of life during recovery follow-up.
Brush Your Teeth, Wear Your Sensors … "Just Checking"The Continua Health Alliance [1] describes the use of recording the presence (or absence) of high-yield micro-events as standard activities, and daily-life parameters that are related to the behavior and well-being of healthy or nondiagnosed peo...