Stroke and dementia

Abstract

Vascular dementia causes dependence and disability. Most stroke survivors show improvement, but many develop dementia. Understanding for vascular dementia has recently improved, leading to improved treatment planning. Further research, especially on treatment for vascular dementia, is greatly needed.

Neuroprotective effects of a traditional herbal prescription on transient cerebral global ischemia in gerbils

“…Cerebral ischemic injury resulting from either focal or global circulatory arrests in the brain, is one of the major causes of death and disability in adults (Pinkston et al, 2009). Global cerebral ischemia is a clinical outcome occurring as a consequence of cardiac arrest, reversible severe hypotension or other situations that deprive the brain of oxygen and glucose (Nedergaard and Diemer, 1988;White et al, 1993).…”

Discrepancy in Expression of β-Secretase and Amyloid-β Protein Precursor in Alzheimer-Related Genes in the Rat Medial Temporal Lobe Cortex Following Transient Global Brain Ischemia

“…Another ambiguous question emerges: Where does the earliest process or do the processes leading to dementia initially begin? AD patients demonstrate neurodegenerative pathology in temporal lobe (disturbances in language) with diagnosed AD dementia [8]. It has been suggested that the primary event of neurodegenerative pathology in AD starts in the medial temporal lobe and proceeds to entorhinal cortex and hippocampus [9,10].…”

Review paper Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

“…Dietary, genetic and molecular factors are important determinants in progression and treatment of the above diseases [1,[47][48][49][50][51]53]. In developed countries ischemic stroke is a major cause of physical disability, the third leading cause of mortality and the second most common cause of dementia [28,41]. In a population of 1 million people 2.4 thousand individuals will have a stroke each year, of whom less than 50% will be independent 1 year later [28].…”

“…Age-related disorders such as Alzheimer's disease and brain ischemia represent a major clinical problem in developed countries [18,28,41] and are a major economic burden for health care systems [15,37]. Dietary, genetic and molecular factors are important determinants in progression and treatment of the above diseases [1,[47][48][49][50][51]53].…”