Stroke in the Young: A Four-Year Study, 1968 to 1972

S, Janaki; Baruah, Jenita; Jayaram, Shubha; Saxena, V K; Sharma, Shailesh; Gulati, Manmeet

doi:10.1161/01.str.6.3.318

Cited by 22 publications

(11 citation statements)

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“…Janaki et al reported that an infection with fever preceded cerebral infarction in 10 of their 26 patients under 20 years of age; in keeping with our results infections were mostly of bacterial origin. 25 The best known example of the association of bacterial infection and stroke is infective endocarditis; cerebral infarction is a complication in 10-15% of cases of bacterial endo-carditis.89 In this study two patients (4%) had cerebral infarction due to endocarditis. Both preceding intoxication with alcohols and a high intake of alcohol6 are associated with ischaemic stroke, which agrees with our results.…”

Section: Discussionmentioning

confidence: 66%

Preceding infection as an important risk factor for ischaemic brain infarction in young and middle aged patients

Syrjänen¹,

Valtonen²,

Iivanainen³

et al. 1988

BMJ

248

134

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The role of preceding infection as a risk factor for ischaemic stroke was investigated in a case-control study of 54 consecutive patients under 50 years of age with brain infarction and 54 randomly selected controls from the community matched for sex and age. Information about previous illnesses, smoking, consumption of alcohol, and use of drugs was taken. A blood sample was analysed for standard biochemical variables and serum cholesterol, high density lipoprotein cholesterol, triglyceride, and fasting blood glucose concentrations determined. Titres of antimicrobial antibodies against various bacteria, including Staphylococcus, Streptococcus, Yersinia, and Salmonelia and several viruses were determined. Febrile infection was found in patients during the month before the brain infarction significantly more often than in controls one month before their examination (19 patients v three controls; estimated relative risk 9-0 (95% confidence interval 2-2 to 80.0)). The most common preceding febrile infection was respiratory infection (80%). Infections preceding brain infarction were mostly of bacterial origin based on cultural, serological, and clinical data. In conditional logistic regression analysis for matched pairs the effect of preceding febrile infection remained significant (estimated relative risk 14-5 (95% confidence interval 1*9 to 112-3)) when tested with triglyceride concentration, hypertension, smoking, and preceding intoxication with alcohol.Although causality cannot be inferred from these data and plausible underlying mechanisms remain undetermined, preceding febrile infection may play an important part in the development of brain infarction in young and middle aged patients.

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Section: Discussionmentioning

confidence: 66%

Preceding infection as an important risk factor for ischaemic brain infarction in young and middle aged patients

Syrjänen¹,

Valtonen²,

Iivanainen³

et al. 1988

BMJ

248

134

View full text Add to dashboard Cite

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“…The leading causes of cerebral thrombosis differ greatly between young and old patients. 4 Typically, most cases in young patients are idiopathic, although there are some reports that point out the existence of a background disease. 5 Currently, especially in North America and Europe, UC is considered to be one of the main causes of cerebral thrombosis since Mayeux and Fahn reported that they suspected that UC was associated with cerebral thrombosis aetiologically.…”

Section: Discussionmentioning

confidence: 99%

Haemorrhagic cerebral sinus thrombosis associated with ulcerative colitis: A case report of successful treatment by anticoagulant therapy

Tsujikawa

Urabe

Bamba

et al. 2000

J of Gastro and Hepatol

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A 29-year-old man with ulcerative colitis was admitted to our hospital because of convulsions and a headache. Before admission, oral prednisolone had been administered due to his ulcerative colitis relapse. Computed tomography revealed a low-density area in the right frontal pole suggestive of a venous infarction. Once his headache and convulsions improved after the administration of an antiepileptic drug, he began to complain of right arm numbness and right hemianopsia again. An urgent magnetic resonance imaging angiograph showed extensive thrombosis in the superior sagittal sinus. We finally used the anticoagulant agents, heparin and urokinase, which eased his complaints and prevented the development of bloody stools. He was discharged with no neurological symptoms 25 days after admission. This is a rare case of sinus thrombosis complicated by ulcerative colitis, in which anticoagulant therapy was successful. Magnetic resonance imaging angiography was useful for the diagnosis and for evaluating the therapeutic effect.

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“…Although the first cases' reports of arterial ischemic stroke (AIS)/acute infantile hemiplegia related to infections issued in the seventies (Roden et al, 1975;Janaki et al, 1975) and though child infections are common, the interest in infectious pediatric strokes had developed recently, probably due to the AIS scarcity (2,4/100,000 US Children per year) (Fullerton et al, 2015). The Vascular Effects of Infection in Pediatric Stroke (VIPS) case control study demonstrated that childhood infections, including varicella zoster virus (VZV), are associated with an increased risk of AIS.…”

Section: Infections and Strokementioning

confidence: 99%