1999
DOI: 10.1159/000015889
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Strokes in the Elderly – Higher Acute and 3-Month Mortality – An Explanation

Abstract: Aim: Stroke is common in older people. The objective of the study was to determine if older stroke patients have a higher mortality and disability compared with younger patients for comparable stroke severity and pathology and whether there is an explanation for the difference. Methods: A prospective study was undertaken in 296 consecutive patients admitted with acute stroke. Patients were studied for neurological features, pre-stroke functional disability, severity of stroke defined by stroke syndromes and pa… Show more

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Cited by 93 publications
(91 citation statements)
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“…6,7,12 Also similar to previous analyses of patients receiving IA rtPA, the rate of HT was no different between age groups, 5,6,13,14 despite the fact that increased age is an independent risk factor for HT following intravenous thrombolysis. 15,16 As with patients receiving IA thombolytics, this finding likely stems from a more rigorous patient selection process and the systemic absence of thrombolytic agents in most cases.…”
supporting
confidence: 71%
See 1 more Smart Citation
“…6,7,12 Also similar to previous analyses of patients receiving IA rtPA, the rate of HT was no different between age groups, 5,6,13,14 despite the fact that increased age is an independent risk factor for HT following intravenous thrombolysis. 15,16 As with patients receiving IA thombolytics, this finding likely stems from a more rigorous patient selection process and the systemic absence of thrombolytic agents in most cases.…”
supporting
confidence: 71%
“…A large intracranial vessel occlusion may irreversibly injure a higher proportion of neurons in an elderly patient than it would in a younger patient under similar circumstances, substantially impeding recovery of neurologic function. 5 Thus, elderly patients may incur more disability regardless of treatment technique. 6 The safety and effectiveness of acute stroke therapies, including intravenous and IA thrombolysis, have been studied in the older population.…”
mentioning
confidence: 99%
“…The mean LANSS score of patients complaining of central pain was 17.75 (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24).…”
Section: Resultsmentioning
confidence: 99%
“…Cognitive impairment after stroke, advanced age, depression, functional impairment, disability, medical problems, and some social factors negatively affect the quality of life (14)(15)(16)(17)(18)(19). Pain secondary to medical problems after stroke, which may develop for a number of reasons, may impair the quality of life.…”
Section: Introductionmentioning
confidence: 99%
“…The risk of symptomatic hemorrhagic transformation (sHT) is not different between the elderly and younger patients, although there are persistent concerns that advanced age increases the risk of sHT related to thrombolysis, 11,12,16,17 By including only the patients received thrombolysis, most of previous studies made a comparison between the old, thrombolysis-treated patients and the young, also thrombolysis-treated ones. Because the elderly patients have more disabling stroke and an increased mortality across a similar spectrum of stroke severity, 1,18 it is natural that we expect worse outcome in the elderly compared to the younger when both are treated with thrombolysis.…”
Section: Introductionmentioning
confidence: 99%