Strong linkage disequilibrium between HLA-B*3913 and DRB1*0807 in Brazilians

Moraes, M. E.; Romero, Marcia; Salomão, Izabella; Correa, M; Gouvea, Nancy Alves de Lima; Hue, Maria I.; Fernandez-Vina, M.; Moraes, José Geraldo Vinci de

doi:10.1016/j.transproceed.2004.03.067

Cited by 4 publications

(5 citation statements)

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“…Of the total number of articles, nine didn't fit in the objectives of the present study (BELICH et al, 1992;BLACK et al, 1980;FERNANDEZ-VINA et al, 1991a;FERNANDEZ-VINA et al, 1991b;FERNANDEZ-VINA et al, 1997;GOLD-BERG et al, 1998;MORAES et al, 2004;SOARES-VIEIRA et al, 1999;TESTA et al, 2004;TRACHTENBERG et al, 1988). In three of them the focus was the HLA class I molecules (BELICH et al, 1992;BLACK et al, 1980;TRACHTENBERG et al, 1988), six articles, although studying HLA class II antigens, did not specified the ethnic origin of the individuals or separated the results according to race/ethnicity (FERNANDEZ-VINA et al, 1991a;FERNANDEZ-VINA et al, 1991b;FERNANDEZ-VINA et al, 1997;GOLD-BERG et al, 1998;MORAES et al 2004;TESTA et al, 2004).…”

Section: Resultsmentioning

confidence: 77%

“…We found twenty-four articles published between 1980 and 2004 about HLA and Brazilian populations (BELICH et al, 1992;BLACK et al, 1980;CERNA et al, 1993;DONADI;SILVA, 2000;ERLICH et al, 1997;FERNANDEZ-VINA et al, 1991a;FER-NANDEZ-VINA et al, 1991b;FER-NANDEZ-VINA et al, 1997;GOLDBERG et al, 1998;LÁZARO et al, 1999;LOUZADA-JUNIOR et al, 2001;MACIAG et al, 2000;MACK;ERLICH, 1998;MORAES et al, 1993;MORAES et al, 2004;PANDO et al, 1994;PETZL-ERLER et al, 1993;PETZL-ERLER;MCDEVITT, 1994;PROBST et al, 2000;SOARES-VIEIRA et al, 1999;SOTOMAIOR et al, 1998;TESTA et al, 2004;TRACHTENBERG et al, 1988;TSUNETO et al, 2003). Of the total number of articles, nine didn't fit in the objectives of the present study (BELICH et al, 1992;BLACK et al, 1980;FERNANDEZ-VINA et al, 1991a;FERNANDEZ-VINA et al, 1991b;FERNANDEZ-VINA et al, 1997;GOLD-BERG et al, 1998;MORAES et al, 2004;SOARES-VIEIRA et al, 1999;TESTA et al, 2004;TRACHTENBERG et al, 1988). In three of them the focus was the HLA class I molecules (BELICH et al, 1...…”

Section: Resultsmentioning

confidence: 98%

“…The HLA-DRB1*0807 allele, associated with -B*3913, was observed only in South-American populations (ERLICH et al, 1997), and it is likely that this association collaborates with the immune response to local pathogens and functional adaptation and might have clinical applications in the selection of bone marrow transplantation. (MORAES et al, 2004) The presence of some alleles and haplotypes in low frequencies, like HLA-DRB1*0801 and -DPB1*0101, in Ticuna tribe may suggest that there is a certain grade of African and Caucasian admixture in this population. (ERLICH et al, 1997;MACK;ERLICH, 1998) Another new allele founded in Guarani's, HLA-DRB1*1413, is similar to -DRB1*1402 (PANDO et al, 1994).…”

Section: (Ii) Methodsmentioning

confidence: 98%

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Polimorfismo do HLA de classe II em populações brasileiras

Alves¹,

Souza²,

Veiga³

et al. 2005

cmbio

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<span class="texto">A investigação da distribuição e freqüência dos genes HLA (Human Leukocyte Antigens) em populações presumivelmente saudáveis é importante para avaliar a participação desses genes na susceptibilidade e proteção a doenças, para avaliar a origem genética das populações e para auxiliar na realização de transplantes. Os avanços na biologia molecular têm permitido um melhor entendimento desse sistema. Além disso, informações sobre as moléculas HLA de classe II, tais como seu mecanismo de ação, função e polimorfismo genético têm colocado esse sistema como marcador da composição das populações. Os genes HLA de classe II parecem ser associados a alguns grupos étnico-raciais mais que a outros. Usando essas características genéticas, é possível demonstrar, por exemplo, o grau de mistura de caucasianos, africanos e ameríndios que contribuem, de modo significante, para a origem da população brasileira, bem como esclarecer alguns aspectos da ancestralidade dessas populações, o que ajuda na realização de estudos populacionais com o objetivo de obter informações sobre a história, formação, migração e composição de grupos populacionais de acordo com suas peculiaridades locais. Esse tema assume relevância em virtude da freqüência dos antígenos, alelos e haplótipos HLA de classe II na população brasileira. <br /></span>

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Section: Resultsmentioning

confidence: 77%

Section: Resultsmentioning

confidence: 98%

Section: (Ii) Methodsmentioning

confidence: 98%

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Polimorfismo do HLA de classe II em populações brasileiras

Alves¹,

Souza²,

Veiga³

et al. 2005

cmbio

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“…Moreover, allele frequencies for HLA Class II alleles (Moraes et al, 1993;Vanderborght et al, 2007) and distribution of B*39 subtypes have been reported for subjects living in Rio de Janeiro (Moraes et al, 2004). Some studies have characterized the distribution of HLA Class I and Class II alleles in populations from other Brazilian regions (Goldberg et al, 1998;Louzada-Junior et al, 2001;Monte et al, 2004;Nigam et al, 2004;Ruiz et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Distribution of CCR5 genotypes and HLA Class I B alleles in HIV-1 infected and uninfected injecting drug users from Rio de Janeiro, Brazil

Teixeira

Bastos

Hacker

et al. 2009

Infection, Genetics and Evolution

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Host genetic factors play an important role in the HIV epidemic dynamics, and have been considered in studies assessing susceptibility/resistance to HIV-1 infection as well as clinical evolution. Class I and Class II HLA alleles have been associated with the heterogeneity of HIV-1 infection susceptibility, as protective or risk factors for HIV-1 transmission. Moreover, a 32-base pair deletion in the HIV-1 CCR5 gene-coding region confers resistance to HIV-1 infection in homozygous individuals for the deleted allele. In this study, DNA samples from HIV-1 infected and uninfected injecting drug users (IDUs) from Rio de Janeiro were PCR amplified to determine CCR5 genotypes based on the presence of the CCR5Delta32 mutation and typed for the HLA-B locus, in an attempt to assess possible associations between these genetic factors and susceptibility/resistance to HIV-1 infection. The distribution of CCR5 genotypes between the two IDU groups did not differ. The homozygous mutant genotype Delta32/Delta32 was not found in this study. Except for HLA-B*45 (4.0% vs. 3.0%; p=0.04) and for B*51 (12.1% vs. 4.4%; p=0.002), no statistically significant differences were made evident when analyzing the frequencies of each HLA-B allele between Caucasian and non-Caucasian IDUs. The most frequent HLA-B alleles were B*15; B*35; B*44 and B*51. Although some differences in the allele frequencies could be observed between the two IDU groups, none of these was statistically significant. Therefore, no putative association between these genetic markers and susceptibility/resistance to HIV-1 infection could be made evident in the present study. So far, the assessment of genetic markers among the IDU population has been restricted to North American, European, and Asian studies and this report represents a pioneer descriptive study of the distribution of CCR5 genotypes and HLA-B alleles in Rio de Janeiro, Brazil.

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“…Examples can be seen in studies of linkage disequilibrium related to bone marrow donation. A strong linkage disequilibrium has been reported for HLA-B*39:13 with the DRB1*04:02, DRB1*08:07 and A*31:12 haplotypes in the Brazilian population [19].…”

Section: Haplotype Linkage Disequilibrium and Expression Of Hla Genesmentioning

confidence: 92%