Strontium ranelate stimulates trabecular bone formation in a rat tibial bone defect healing process

Lavet, C.; Mabilleau, Guillaume; Chappard, Daniel; Rizzoli, René; Ammann, Patrick

doi:10.1007/s00198-017-4156-3

Cited by 21 publications

(18 citation statements)

References 47 publications

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“…First, they may be due to the short treatment period of 2 or 3 weeks, which for such a complicated model is not long enough to exhibit effects sufficient to convert the molecular benefits into radiological and histologic changes [ 55 ]. Second, while the SR dosage of 600 mg/kg/d in the present study can lead to a blood strontium concentration close to the human therapeutic exposure [ 22 ], this is a relatively lower dosage when considering the 450–900 mg/kg used in previous studies, where it displayed positive effects on bone formation in bone-defect and fracture models [ 22 , 56 – 62 ]. Further study is needed to determine whether a higher SR dose would exhibit a significant effect on fracture healing in the model of combined estrogen deficiency and diabetes.…”

Section: Discussionmentioning

confidence: 99%

Strontium Ranelate Combined with Insulin Is as Beneficial as Insulin Alone in Treatment of Fracture Healing in Ovariectomized Diabetic Rats

et al. 2018

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BackgroundType 2 diabetes mellitus (T2DM) and estrogen deficiency both predispose fracture patients to increased risk of delayed union or nonunion. The present study investigated the effects of strontium ranelate (SR) on fracture healing in ovariectomized (OVX) diabetic rats.Material/MethodsA mid-shaft fracture was established in female normal control (CF), diabetic (DF), and OVX diabetic (DOF) rats. Treated DOF rats received either insulin alone (DOFI) or combined with SR (DOFIS). All rats were euthanized at 2 or 3 weeks after fracture. Fracture healing was evaluated using radiological, histological, immunohistochemical, and micro-computed tomography analyses.ResultsAt 3 weeks after fracture, radiological and histological evaluations demonstrated delayed fracture healing in the DF group compared with the CF group, which was exacerbated by OVX, as indicated by the significantly lower X-ray score, BMD, BV/TV, and Md.Ar/Ps.Cl.Ar, and the markedly decreased OCN and Col I expression in the DOF group. All these changes were prevented by insulin alone or combined with SR treatment. In comparison with the DOFI group, DOFIS rats displayed markedly higher OCN expression at 2 weeks after fracture and Col I expression at 2 and 3 weeks after fracture.ConclusionsThese results demonstrated delayed fracture healing with preexisting estrogen deficiency and T2DM. While insulin alone and combined with SR were both effective in promoting bone fracture healing in this model, their combined treatment showed significant improvement in promoting osteogenic marker expression, but not of the radiological appearance, compared with insulin alone.

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Section: Discussionmentioning

confidence: 99%

Strontium Ranelate Combined with Insulin Is as Beneficial as Insulin Alone in Treatment of Fracture Healing in Ovariectomized Diabetic Rats

et al. 2018

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“…88 Since it has outstanding properties for bone tissue engineering, various authors decided to evaluate the effects of this compound (Fig. 4): a SR therapy was investigated to assess its effects on fracture frequency and bone mass and strength in mice; 89 a SR treatment was examined in a postmenopausal woman with osteonecrosis of the jaw after long-term oral bisphosphonate administration; 90 SR in the repair of standardized intrabuccal bone defects in Lewis rats was evaluated; 91 the effects of insulin and SR on guided bone regeneration in diabetic Wistar rats were analysed; 92 how a previous biophosphonate treatment can modify the effects of SR on bone mineral density was investigated in humans; 93 the properties of SR for the stimulation of trabecular bone formation in a Sprague-Dawley rat tibial bone defect healing process; 94 the effects of SR on spinal interbody fusion surgery in an osteoporotic Sprague-Dawley rat; 95 and finally, how SR causes osteophyte overgrowth in a model of early phase osteoarthritis in Dunkin Hartley albino guinea pigs. 96…”

Section: Strontium Ranelate Based Therapiesmentioning

confidence: 99%

Bibliographic review on the state of the art of strontium and zinc based regenerative therapies. Recent developments and clinical applications

Jiménez¹,

Abradelo²,

Román

et al. 2019

J. Mater. Chem. B

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“…Strontium (Sr) is an essential trace element in the human body, which has dual effects of promoting bone formation 10,11 and inhibiting bone resorption. 12,13 Strontium ranelate has been successfully used to treat osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

<p>Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits</p>

Zhao

et al. 2020

IJN

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Enhancing osteointegration of implants in osteoporosis patients is a necessity since implantations frequently fail in these patients. The aim of this work is to study how simvastatin-strontium-hydroxyapatite coated implants perform in rabbits with osteoporosis. Materials and Methods: Crystalline HA and Sr-HA oxide film were prepared through micro-arc oxidation. Surface characterization including morphology, roughness, element composition, phase composition, hydrophilicity were then evaluated. Simvastatin loaded on porous films through immersion, and the effects of coatings on osteointegration in osteoporotic rabbits were investigated. All samples were obtained after 4, 8 and 12 weeks of healing. Some of them were subjected to biomechanical tests and others were subjected to histological and histomorphometric analysis. Results: Coatings exhibited a microporous network structure with appropriate roughness and high hydrophilicity. Compared to control HA and machined surface implants, simvastatin-Sr-HA coated implants exhibited marked improvements in osteointegration, which is characterized by a quicker mineralization deposition rate, good bone formation mode (large amount of contact osteogenesis and a small amount of distance osteogenesis) and increased bone-to-implant contact and pull-out strength. Conclusion: These biological parameters demonstrate the excellent osteoconductivity of simvastatin-Sr-HA coatings in the osteoporotic state. Overall, this suggests that simvastatin-Sr-HA coatings would be applicable in poor-quality bones of patients experiencing osteoporosis.

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Strontium ranelate stimulates trabecular bone formation in a rat tibial bone defect healing process

Abstract: SrRan affects bone formation differently in normal mature bone or in the bone healing process. Despite this selective action, this led to similar increased bone volume in both compartments without deleterious effects on the newly bone-formed quality.

Cited by 21 publications

References 47 publications

Strontium Ranelate Combined with Insulin Is as Beneficial as Insulin Alone in Treatment of Fracture Healing in Ovariectomized Diabetic Rats

Strontium Ranelate Combined with Insulin Is as Beneficial as Insulin Alone in Treatment of Fracture Healing in Ovariectomized Diabetic Rats

Bibliographic review on the state of the art of strontium and zinc based regenerative therapies. Recent developments and clinical applications

<p>Influence of Simvastatin-Strontium-Hydroxyapatite Coated Implant Formed by Micro-Arc Oxidation and Immersion Method on Osteointegration in Osteoporotic Rabbits</p>

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