Structural and electrokinetic characteristics of track-etched initial membranes and membranes modified with perfluorinated sulfocationic ionomer

Ермакова, Л. Э.; Sidorova, M. P.; Kiprianova, A. A.; Gamaliya, D. S.; Savina, I. A.

doi:10.1134/s1061933x08040066

Cited by 3 publications

(3 citation statements)

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“…The track-etched PET membranes have an isoelectric point (pI = 3.8) [39], and the nanochannel shows hydrophilic behaviour due to the presence of ionized carboxylate (-COO − ) groups at neutral pH [40]. In order to observe the influence of BSA on the rectification behaviour, an electrolyte consisting of 0.1 M KCl and 100 nM BSA was placed on the side, facing the tip opening of the channel at different pH values.…”

Section: Resultsmentioning

confidence: 99%

Fabrication and functionalization of single asymmetric nanochannels for electrostatic/hydrophobic association of protein molecules

Ali

Bayer²,

Schiedt

et al. 2008

Nanotechnology

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We have developed a facile and reproducible method for surfactant-controlled track-etching and chemical functionalization of single asymmetric nanochannels in PET (polyethylene terephthalate) membranes. Carboxyl groups present on the channel surface were converted into pentafluorophenyl esters using EDC/PFP (N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride/pentafluorophenol) coupling chemistry. The resulting amine-reactive esters were further covalently coupled with ethylenediamine or propylamine in order to manipulate the charge polarity and hydrophilicity of the nanochannels, respectively. Characterization of the modified channels was done by measuring their current-voltage (I-V) curves as well as their permselectivity before and after the chemical modification. The electrostatic/hydrophobic association of bovine serum albumin on the channel surface was observed through the change in rectification behaviour upon the variation of pH values.

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Section: Resultsmentioning

confidence: 99%

Fabrication and functionalization of single asymmetric nanochannels for electrostatic/hydrophobic association of protein molecules

Ali

Bayer²,

Schiedt

et al. 2008

Nanotechnology

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“…The electrostatic interaction between charged analytes in solution and fixed charges, as described above, is also the driving force responsible for the flux variation of MV 2+ and NDS 2− across our nanochannel membranes. The track-etched PET membranes have an isoelectric point (pI 3.8) [40], so that at neutral pH, ionized carboxylate (−COO − ) anions import negative charges to the walls of the nanochannels. Therefore, the carboxylated multichannel membrane only allows the selective transport of positively charged (MV 2+ ) molecules and rejects negatively charged NDS 2− molecules.…”

Section: Permeation Of Charged Organic Moleculesmentioning

confidence: 99%

Charge-selective transport of organic and protein analytes through synthetic nanochannels

Nguyen¹,

Ali²,

Bayer³

et al. 2010

Nanotechnology

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We present an experimental demonstration of a synthetic nanoporous membrane suitable for charge-selective transport of ionic species. The surfaces and walls of synthetic nanochannels, fabricated in heavy ion-tracked polyethylene terephthalate membranes are negatively charged due to the presence of carboxylate moieties. These nanofilters discriminate and gate the transport of cations while inhibiting the passage of anions. The permselectivity of these membranes is reversed by converting the carboxylic moieties into terminated amino groups. The positively charged (aminated) membranes facilitate the transport of anions. Based on the same principle, charged biomolecules (bovine serum albumin and lysozyme) are successfully filtered through these membranes. These membranes also exhibit the phenomenon of ion concentration polarization.

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“…Membrane science and technology [1], in particular, stimuliresponsive nanoporous membranes, is attracting increasing attention because of their broad applications for selective separation, biochemical sensing, and controlled release and drug delivery processes [2][3][4][5][6][7][8][9][10][11][12][13][14][15]. In nature, the ion channels facilitate the selective transport of ions and small organic molecules across the cell membrane.…”

Section: Introductionmentioning

confidence: 99%

Thermally controlled permeation of ionic molecules through synthetic nanopores functionalized with amine-terminated polymer brushes

2012

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We present temperature-dependent ionic transport through an array of nanopores (cylindrical and conical) and a single conical nanopore functionalized with amine-terminated poly(N-isopropylacrylamide) [PNIPAAM-NH2] brushes. For this purpose, nanopores are fabricated in heavy ion irradiated polyethylene terephthlate (PET) membranes by a controlled chemical track-etching technique, which leads to the generation of carboxyl (COOH) groups on the pore surface. End-functionalized polymer chains are immobilized onto the inner pore walls via a 'grafting-to' approach through the covalent linkage of surface COOH moieties with the terminal amine groups of the PNIPAAM molecules by using carbodiimide coupling chemistry. The success of the chemical modification reaction is corroborated by measuring the permeation flux of charged analytes across the multipore membranes in an aqueous solution, and for the case of single conical pore by measuring the current-voltage (I-V) characteristics, which are dictated by the electrostatic interaction of the charged pore surface with the mobile ions in an electrolyte solution. The effective nanopore diameter is tuned by manipulating the environmental temperature due to the swelling/shrinking behaviour of polymer brushes attached to the inner nanopore walls, leading to a decrease/increase in the ionic transport across the membrane. This process should permit the thermal gating and controlled release of ionic drug molecules through the nanopores modified with thermoresponsive polymer chains across the membrane.

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Structural and electrokinetic characteristics of track-etched initial membranes and membranes modified with perfluorinated sulfocationic ionomer

Cited by 3 publications

References 0 publications

Fabrication and functionalization of single asymmetric nanochannels for electrostatic/hydrophobic association of protein molecules

Fabrication and functionalization of single asymmetric nanochannels for electrostatic/hydrophobic association of protein molecules

Charge-selective transport of organic and protein analytes through synthetic nanochannels

Thermally controlled permeation of ionic molecules through synthetic nanopores functionalized with amine-terminated polymer brushes

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