2014
DOI: 10.1073/pnas.1400806111
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Structural and functional brain rewiring clarifies preserved interhemispheric transfer in humans born without the corpus callosum

Abstract: Why do humans born without the corpus callosum, the major interhemispheric commissure, lack the disconnection syndrome classically described in callosotomized patients? This paradox was discovered by Nobel laureate Roger Sperry in 1968, and has remained unsolved since then. To tackle the hypothesis that alternative neural pathways could explain this puzzle, we investigated patients with callosal dysgenesis using structural and functional neuroimaging, as well as neuropsychological assessments. We identified tw… Show more

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Cited by 107 publications
(125 citation statements)
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“…2009; Tovar‐Moll et al. 2014), and it is widely assumed that structural connectivity is relatively stable over time, whereas functional connectivity is more variable (Zhang et al. 2011).…”
Section: Discussionmentioning
confidence: 99%
“…2009; Tovar‐Moll et al. 2014), and it is widely assumed that structural connectivity is relatively stable over time, whereas functional connectivity is more variable (Zhang et al. 2011).…”
Section: Discussionmentioning
confidence: 99%
“…I agree with her on this point-(1) makes best sense of why acallosals perform the same as normal subjects in split-brain experiments and it is backed up with neurophysiological evidence (Tovar-Moll et al 2014). Although Hurley thinks that interpretation (1) provides the best explanation of acallosals, she does argue that interpretation (2) should be taken seriously as a nomological possibility.…”
Section: Split-brain Syndrome and The Experimental Aberration Modelmentioning
confidence: 75%
“…They have large brains with many billion neurons and glial cells (Lent et al, 2012), trillions of synapses and besides all, a plastic hardware that may change either subtly or strongly in response to the external or internal environment (Tovar-Moll et al, 2014). With this hypercomplex apparatus, they are capable of very sophisticated inward computations and outward behaviors that include self-recognition, metacognition, different forms of language expression and reception, prediction of future events, planning and performing long streams of motor acts, subtle emotional feelings, and many other exceedingly complex properties.…”
mentioning
confidence: 99%
“…This evolutionary trajectory as related to developmental mechanisms is reviewed by Rodrigo Suarez and his colleagues from Queensland Brain Institute, Australia. The corpus callosum, in particular, is the target of their interest, and the knowledge of the developmental events underlying its formation is instrumental to unravel its striking long-distance plasticity, as shown in cases of humans born without it (Tovar-Moll et al, 2014).…”
mentioning
confidence: 99%