This study aims to identify cancer adaptation of breast cancer patients with high incidence in Korea and to analyze whether family support and self-efficacy affect. This correlational study was conducted among 75 middle-aged cancer patients with cancer living in the S and K regions in Korea. For data collection, a structured questionnaire was used for subjects who agreed to the study. The study tool measured breast cancer adaptation, family support, and self-efficacy and the collected data were analyzed using the SPSS / WIN 23.0 program. The general characteristics and degree of cancer adaptation, family support, and self-efficacy were analyzed using frequency and percentage, mean, and standard deviation, and the Pearson's coefficient was used for correlation between cancer adaptation, family support, and self-efficacy. The results showed that middle-aged breast cancer patients' cancer adaptation score was 77.03 (± 6.79). The family support score was 14.56 (± 13.28), and the self-efficacy was 40.15 (± 12.26). The results show that, as family support and self-efficacy increased, the breast cancer adaptation result increased. Therefore, we suggest collecting basic data for the development of programs that can enhance cancer adaptation for middle-aged breast cancer patient.