2013
DOI: 10.1186/1752-153x-7-53
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Structural features, kinetics and SAR study of radical scavenging and antioxidant activities of phenolic and anilinic compounds

Abstract: BackgroundPhenolic compounds are widely distributed in plant kingdom and constitute one of the most important classes of natural and synthetic antioxidants. In the present study fifty one natural and synthetic structurally variant phenolic, enolic and anilinic compounds were examined as antioxidants and radical scavengers against DPPH, hydroxyl and peroxyl radicals. The structural diversity of the used phenolic compounds includes monophenols with substituents frequently present in natural phenols e.g. alkyl, a… Show more

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Cited by 94 publications
(58 citation statements)
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“…The obvious structural feature that all active compounds shared was the presence of two hydroxyl groups located at neighboring carbon atoms at the phenyl ring of the coumarin scaffold. This observation was in agreement with the results of a study on phenolic compounds that showed that two hydroxyl groups in ortho or para position of each other were optimal for radical scavenging activity [33]. Compounds 1-3 were also included in the study by Lin and coworkers and the reported findings agreed well with the ones reported here [13].…”
Section: Structure-activity Relationships For Radical Scavenging Bsupporting
confidence: 82%
“…The obvious structural feature that all active compounds shared was the presence of two hydroxyl groups located at neighboring carbon atoms at the phenyl ring of the coumarin scaffold. This observation was in agreement with the results of a study on phenolic compounds that showed that two hydroxyl groups in ortho or para position of each other were optimal for radical scavenging activity [33]. Compounds 1-3 were also included in the study by Lin and coworkers and the reported findings agreed well with the ones reported here [13].…”
Section: Structure-activity Relationships For Radical Scavenging Bsupporting
confidence: 82%
“…Lin et al 28 reported that thymol and carvacrol were the major components attributing the DPPH free radical scavenging activity in the thyme wild essential oil. In the study of Ali et al 29 carvacrol exhibited 33.9% radical scavenging activity at 5 mM concentration. Therefore, the observed radical scavenging activity of the essential oil is mainly attributed to its main constituent carvacrol.…”
Section: 2-diphenyl-1-picrylhydrazyl Radical Scavenging Activity Ofmentioning
confidence: 99%
“…Phenolic compounds are widely accepted and recommended for their antioxidant activities [1][2][3]. The chemical structure of the phenolic compounds imparts them the ability to serve as free radical scavengers.…”
Section: Introductionmentioning
confidence: 99%