Structural investigation of spherical hollow excipient Mannit Q by X-ray microtomography

Single droplets to particles - size, shape, shell thickness and porosity analyses using X-ray computed tomography

“…The rendered 3D volume is produced through the reconstruction of the cross sectional XCT images of the object [25]. XCT has been used previously in the characterisation of size and shape [17,[26][27][28][29], porosity [17,23,26,30] and the microstructure of solids [28,[31][32][33]. Since the robustness of imaging techniques such as XCT may be affected by the method of data collection, image reconstruction and image processing strategy employed, the method of analysis must be designed to optimise the representation of key information specific to the sample of interest [25,34].…”

WITHDRAWN: 3D characterisation of dry powder inhaler formulations: Developing X-ray micro computed tomography approaches

“…and thoephylline anhydrate [46]. It has also been used to study particle coatings [48], fine granules [45], particle hollowness [28] and the microstructure of microcrystalline cellulose [12]. Recent developments in source and detector technology have improved the resolution and scanning speeds of laboratory machines [38], and coupled with falling capital costs [29], they have made XCT a more accessible laboratory technique.…”

Unraveling the droplet drying characteristics of crystallization‐prone mannitol – experiments and modeling

“…It is a rapid and well established one‐step process that produces particles of controllable size and shape, with high throughput . Several studies have shown that particle properties can be varied by manipulating the process or formulation parameters, for example, by modifying the drying conditions, using different precursor concentrations, adopting template substrates, and changing the type of solvent . Despite these studies, the fundamental microscopic mechanism related to the drying process of mannitol droplets has remained relatively unknown.…”