Structural model of polymeric nanospheres containing indomethacin ethyl ester and in vivo antiedematogenic activity

Pohlmann, Adriana Raffin; Cruz, Letícia; Mezzalira, Graziela; Soares, Leonardo Uhlmann; Silveira, Nádya Pesce da; Guterres, Sílvia Stanisçuaski

doi:10.1504/ijnt.2007.014744

Cited by 14 publications

(9 citation statements)

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“…6 Polymeric nanoparticles have been widely investigated not only as drug carriers because of their acceptable biocompatibility and biodegradability [7][8][9] but also as coating material of complex architecture microparticles. 10 11 Those nanoparticles are nanospheres which consist of polymeric matrix 12 or nanocapsules when a polymeric wall is enveloping an oil core. 13 methoxycinnamate) as oil core significantly increased the protection against UV-induced erythema compared to the control gel containing the free sunscreen.…”

Section: Introductionmentioning

confidence: 99%

Semisolid Formulation Containing a Nanoencapsulated Sunscreen: Effectiveness, <I>In Vitro</I> Photostability and Immune Response

Paese

Jäger²,

Poletto³

et al. 2009

Journal of Biomedical Nanotechnology

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The objective of this work was to verify if hydrophilic gels containing benzophenone-3 loaded nanocapsules (HG-NC BZ3 could improve the sunscreen in vitro effectiveness against UVA radiation and its photostability compared to a conventional hydrogel containing the free sunscreen (HG-BZ3). In parallel, the immune response of the nanostructured system was evaluated by mouse ear swelling test and the local lymph node assay. The nanocapsules were prepared by interfacial deposition of poly(epsilon-caprolactone) and characterized in terms of particle size, polydispersity index, zeta potential, drug content and encapsulation efficiency. HG-NC BZ3 UV scans showed higher absorption intensity values than HG-NC placebo , prepared using unloaded nanocapsules. Films of the gels were irradiated with UVA light and the BZ3 recovery was evaluated by HPLC. BZ3 recovery decreased from 100% to 29% for HG-BZ3 and to 56% for HG-NC BZ3 after 13 h. After wavelength scans within 13 h, the relative areas under the curves (AUC) decreased from 1.00 to 0.62 for HG-BZ3 and remained constant for HG-NC BZ3 . Sensitization assay showed that stimulation indexes lower than 3 for all the hydrogel samples. Formulations did not induce increases higher than 10% in ear swelling, indicating that the hydrogels did not cause cutaneous sensitization in mice. The nanoencapsulation improved both the photostability and the effectiveness of BZ3 compared to the non-encapsulated sunscreen and the topical application of free and nanoencapsulated BZ3 did not produced significant allergy response in mice.

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Section: Introductionmentioning

confidence: 99%

Semisolid Formulation Containing a Nanoencapsulated Sunscreen: Effectiveness, <I>In Vitro</I> Photostability and Immune Response

Paese

Jäger²,

Poletto³

et al. 2009

Journal of Biomedical Nanotechnology

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“…One of the suggested alternatives for avoiding the side effects caused by oral administration of NSAIDs is the use of colloidal systems which can also improve the selectivity and efficacy of the poorly water-soluble drugs [14][15][16]. The delivery of drugs using nanoparticles is promising because it has shown better results than formulations in solution [3,15,17,18].…”

Section: Introductionmentioning

confidence: 99%

Semi-solid topical formulations containing nimesulide-loaded nanocapsules showed in-vivo anti-inflammatory activity in chronic arthritis and fibrovascular tissue models

et al. 2011

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“…Figura 1 -Representação esquemática da pele: a) epiderme; b) derme e c) hipoderme (GUTERRES;POHLMANN, 2007).…”

Section: Pele: Uma Rota Para Administração Tópicaunclassified

“…Muitos fatores são capazes de comandar a liberação das moléculas ativas dentro da pele após a administração de formulações tópicas. Estes fatores incluem massa molecular e lipofilicidade da substância, tipo de formulação, presença de um melhor composto para penetração e estado físico do estrato córneo (GUTERRES; ALVES; POHLMANN, 2007).…”

Section: Pele: Uma Rota Para Administração Tópicaunclassified

“…Dentre estas características destaca-se a potencial ação como bloqueadores das radiações UV, atuando como filtros físicos e podendo ser combinados a filtros químicos melhorando a fotoproteção (WISSING;MULLER, 2003;PAESE, 2008). Estes sistemas carreadores apresentam um tamanho reduzido, o qual possibilita um maior contato das moléculas ativas com o estrato córneo, além de facilitar sua formulação em produtos dermatológicos e propiciar confortável aplicação cutânea (ALVES et al, 2007;GUTERRES;POHLMANN, 2007;PAESE, 2008).…”

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Avaliação de amidos hidrolisados, aniônico e catiônico, como tensoativos nas formulações de nanopartículas poliméricas para aplicação em filtros solares

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Structural model of polymeric nanospheres containing indomethacin ethyl ester and in vivo antiedematogenic activity

Cited by 14 publications

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Semisolid Formulation Containing a Nanoencapsulated Sunscreen: Effectiveness, <I>In Vitro</I> Photostability and Immune Response

Semisolid Formulation Containing a Nanoencapsulated Sunscreen: Effectiveness, <I>In Vitro</I> Photostability and Immune Response

Semi-solid topical formulations containing nimesulide-loaded nanocapsules showed in-vivo anti-inflammatory activity in chronic arthritis and fibrovascular tissue models

Avaliação de amidos hidrolisados, aniônico e catiônico, como tensoativos nas formulações de nanopartículas poliméricas para aplicação em filtros solares

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