Structural modification and biological activity studies of tagitinin C and its derivatives

Au, Thi Hang; Skarbek, Charles; Pèthe, Stéphanie; Labruère, Raphaël; Baltaze, Jean‐Pierre; Nguyen, Thi Phuong Hoa; Vu, Thi Thu Ha

doi:10.1016/j.tet.2021.132248

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…Results demonstrated that the most sensitive cell line was the pancreatic one (MiaPaCa-2) as more than 80% of cancerous cells did not survive after 72 h of incubation with the compounds at the concentration tested (1µM). Additionally, the derivatives were more cytotoxic than tagitinine C (22% cell viability for tagitinine C vs. 6.6–21% for the new compounds) [ 119 ].…”

Section: Other Bioactive Sesquiterpene Lactones Tested In Pdac Modelsmentioning

confidence: 99%

Sesquiterpene Lactones as Promising Candidates for Cancer Therapy: Focus on Pancreatic Cancer

et al. 2022

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Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease which confers to patients a poor prognosis at short term. PDAC is the fourth leading cause of death among cancers in the Western world. The rate of new cases of pancreatic cancer (incidence) is 10 per 100,000 but present a 5-year survival of less than 10%, highlighting the poor prognosis of this pathology. Furthermore, 90% of advanced PDAC tumor present KRAS mutations impacting in several oncogenic signaling pathways, many of them associated with cell proliferation and tumor progression. Different combinations of chemotherapeutic agents have been tested over the years without an improvement of significance in its treatment. PDAC remains as one the more challenging biomedical topics thus far. The lack of a proper early diagnosis, the notable mortality statistics and the poor outcome with the available therapies urge the entire scientific community to find novel approaches against PDAC with real improvements in patients’ survival and life quality. Natural compounds have played an important role in the process of discovery and development of new drugs. Among them, terpenoids, such as sesquiterpene lactones, stand out due to their biological activities and pharmacological potential as antitumor agents. In this review, we will describe the sesquiterpene lactones with in vitro and in vivo activity against pancreatic tumor cells. We will also discuss the mechanism of action of the compounds as well as the signaling pathways associated with their activity.

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Section: Other Bioactive Sesquiterpene Lactones Tested In Pdac Modelsmentioning

confidence: 99%

Sesquiterpene Lactones as Promising Candidates for Cancer Therapy: Focus on Pancreatic Cancer

et al. 2022

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“…Bis[6(methylsulfinyl)hexyl] urea compounds contain strong anti-HIV properties which inhibit the enzyme HIV-1 protease (Gupta et al 1998). Tagitinin C has a wide range of pharmacological functions including anti-inflammatory, cytotoxic, antiviral, antibacterial, antifungal, and allelopathic properties (Au et al 2021).…”

Section: Phytochemical Compounds Of Selected Medicinal Plantmentioning

confidence: 99%

Ethnomedicinal study, phytochemical characterization, and pharmacological confirmation of selected medicinal plant on the northern slope of Mount Wilis, East Java, Indonesia

et al. 2022

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Abstract. Bhagawan WS, Suproborini A, Putri DLP, Nurfatma A, Putra RT. 2022. Ethnomedicinal study, phytochemical characterization, and pharmacological confirmation of selected medicinal plant on the northern slope of Mount Wilis, East Java, Indonesia. Biodiversitas 23: 4303-4313. The traditional usage of plants in ethnomedicine is a valuable resource for human primary healthcare. The effectiveness of herbal medicines and the creation of new drugs are proven by pharmacological and phytochemical verification. This study documented the traditional ethnomedicine knowledge (TEK) on the northern slope of Mount Wilis community in utilizing medicinal plants and revealed the ethnopharmacology relevance of selected medicinal plants. Data on TEK and its practices were collected through in-depth and semi-structured interviews with informants who were selected using purposive sampling and snowball sampling techniques. The phytochemical compounds of the selected medicinal plant were identified using the UPLC-Qtof-MS/MS instrument, while their pharmacological activity was measured in antibacterial tests. The results showed that the community continued to apply TEK that had been passed down by the previous generation through a method called Gethok Tular. The medicinal plant species in the study area were diverse, 82 species from 39 families with various modes of preparation were used to treat seven disease categories. Tithonia diversivolia had the highest use value of 0.65 and it contained 23 phytochemical compounds. In addition, this plant has high pharmacological potential for antibacterial agents.

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Research on the anti-hepatic fibrosis effects and active components of the medicinal plant Tithonia diversifolia

Wang,

Li,

Wang

et al. 2025

Fitoterapia

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Structural modification and biological activity studies of tagitinin C and its derivatives

Cited by 5 publications

References 31 publications

Sesquiterpene Lactones as Promising Candidates for Cancer Therapy: Focus on Pancreatic Cancer

Sesquiterpene Lactones as Promising Candidates for Cancer Therapy: Focus on Pancreatic Cancer

Ethnomedicinal study, phytochemical characterization, and pharmacological confirmation of selected medicinal plant on the northern slope of Mount Wilis, East Java, Indonesia

Research on the anti-hepatic fibrosis effects and active components of the medicinal plant Tithonia diversifolia

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