Structure–activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives

Antibacterial activity of alkyl gallates and related compounds against Ralstonia solanacearum

“…16) An inverse correlation is observable between 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging efficiency and log P, 17) but the difference in IC 50 of radical scavenging efficiency between methyl gallate and dodecyl gallate is less than two and is much smaller than the difference in antibacterial activity. 13,14) The radical scavenging efficiency of gallic acid is a little stronger than methyl gallate.…”

“…13,14) The radical scavenging efficiency of gallic acid is a little stronger than methyl gallate. 17) Thus, it seems unlikely that the hydrophobicity or the radical scavenging activity of alkyl gallates is connected with its antibacterial activity in R. solanacearum.…”

Curcumin protects against gallic acid-induced oxidative stress, suppression of glutathione antioxidant defenses, hepatic and renal damage in rats

“…6,7 However, the potential of Gal to function as antioxidant may be dependent on the dose and their molecular polarities, which could account for the controversial function of Gal as an antioxidant and pro-oxidant molecule. 8 Thus, Gal is cytotoxic to human blood lymphocytes by mechanism involving paradoxical generation of reactive oxygen species. 7,9 We also recently reported decreased activities of antioxidant enzymes and GSH level without the induction of lipid peroxidation in the testis of rats as a result of Gal treatment for 30 days.…”

Gallic Acid-loaded Cellulose Acetate Electrospun Nanofibers: Thermal Properties, Mechanical Properties, and Drug Release Behavior

“…It has several biological activities including antioxidant, antityrosinase, antimicrobial, anti-inflammatory and anticancer activities [16][17][18]. Due to its promising antioxidant activity, gallic acid is added in various skincare products in the form of natural herbal extracts.…”