Structure and musk odour: II. Benzene derivatives

Abstract

A n d e r of simple &nzene derivatives with mu& odour are described.In a recent paper * a series af new indane derivatives with a musk odour was described. In this series the compound with the strongest musk odour was found to be 4acetyl-lf1-dimethyl-6-t~butylindane (I). +It seemed interestinq to investigate whether 6he non-aromatic ring in the indane system is a requirement for the musk odour or ~h e t h e r it only serves as a convenient camier for some of the essential substituents. The latter was found to be the case: 3,5idi-t-butylacetophenone (11; white crystals: melting point: 38.639.0 a), a lower homolague of I in wlhich the nonaromatic ring h-as been opened while the * The compounds described in this paper are the subject of patent appli-

Cycloalkane and Alicyclic Heterocycle Complexation by New Switchable Resorcin[4]arene‐Based Container Molecules: NMR and ITC Binding Studies

“…Condensation of resorcinol with aldehyde 3, following standard procedures, afforded octol 6 in 33 % yield. [15] Bridging of 6 with 2,3-dichloroquinoxaline afforded cavitand 7 [12][13][14][15][16] from which two bridges were selectively removed to afford anti-tetrol 8 (Scheme 1 A). [13,17,18] In contrast to our previously published work, [1,2] the basket bridge was introduced in one single step.…”