Structure controlling and process scale-up in the fabrication of nanomaterials

Abstract

Nanotechnology is already having a significant commercial impact, and will very certainly have a much greater impact in the future. The research on process engineering and scale-up will be very important for the commercial production and application of nanomaterials, because the properties and structure of nanomaterials are not only determined by the nucleation and growth process, but also strongly affected by the engineering properties, such as the mixing, the heat and mass transfer, and also the distribution of temperature, concentration, etc. This paper will present some research work in our laboratory on the fabrication of nanomaterials. Based on the chemical engineering principle and methods, many kinds of novel nanomaterials can be synthesized and their structure can be easily controlled through adjusting the parameters of the fluid mixing, and the distribution of temperature, residence time and concentration, etc. By using the micro-mixing, heat and mass transfer and reaction control methods, the host-guest nanocomposites have been assembled and assumed as the novel electroanalytical sensing nanobiocomposite materials. Based on the principles of chemical engineering, the manufacturing technologies for magnetic powders, calcium carbonate, and titanium dioxide have been developed for commercial-scale production, and the largest production scale has reached 15 kt/year.

Multimodal Dispersion of Nanoparticles: A Comprehensive Evaluation of Size Distribution with 9 Size Measurement Methods

“…In industries, physical properties knowledge is important to understand and opti mize processes. For instance, particle size and particle size distribution (PSD) measurements are paramount to investi gate the repeatability and the efficiency of various industrial processes and products (11). In medicine, desired properties of the nanoparticles could be drawn by controlling nanoparticle size among other physico chemical characteristics (12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Practical Guidelines for the Characterization and Quality Control of Nanoparticles in the Pharmaceutical Industry

“…Modifications of size parameters and surface properties of nanomedicines can affect their biological fate hence biological efficacy and safety 38,39 . Size parameters and surface properties of NMs are among paramount factors to evaluate in order to assess repeatability and reproducibility and efficiency of industrial processes and product quality 40 . The Table 1 summarizes the different methods that are available to assess specific physicochemical parameters of NMs.…”

Development and Upscaling of SiO2@TiO2 Core-Shell Nanoparticles for Methylene Blue Removal

“…One of the major barriers is the technology transfer to industry [ 25 , 26 ]. Regarding SiO 2 @TiO 2 NPs, there are still poor solutions for their large-scale synthesis toward industrial production, and emerging strategies to improve the reproducible synthesis of large batches are needed to satisfy the future demand [ 26 , 27 ]. The hydrothermal method is regarded as a suitable synthetic approach and is one of the strategies adopted during the nanoparticle crystallization process.…”