Structure Function Analysis of an ADP-ribosyltransferase Type III Effector and Its RNA-binding Target in Plant Immunity

Jeong, Byeong‐ryool; Lin, Yan; Joe, Anna; Guo, Ming; Korneli, Christin; Yang, Huirong; Wang, Ping; Yu, Min; Cerny, Ronald L.; Staiger, Dorothee; Alfano, James R.; Xu, Yanhui

doi:10.1074/jbc.m111.290122

Cited by 89 publications

(90 citation statements)

References 60 publications

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“…The RBP and SF At-GRP7, discussed above, is also involved in plant immunity, and ADP ribosylation of a conserved RNA binding Arg residue by a bacterial effector protein interferes with plant defense (Jeong et al, 2011;Nicaise et al, 2013). At-GRP7 has been shown to upregulate PATHOGENESIS RELATED transcripts associated with SA-dependent defense and downregulate transcripts associated with jasmonic acid (JA)/ethylene dependent defense, but a role in AS of defense-associated transcripts has not yet been described (Hackmann et al, 2013).…”

Section: Factors Involved In As Of R Genes and Plant Defensementioning

confidence: 99%

Alternative Splicing at the Intersection of Biological Timing, Development, and Stress Responses

2013

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High-throughput sequencing for transcript profiling in plants has revealed that alternative splicing (AS) affects a much higher proportion of the transcriptome than was previously assumed. AS is involved in most plant processes and is particularly prevalent in plants exposed to environmental stress. The identification of mutations in predicted splicing factors and spliceosomal proteins that affect cell fate, the circadian clock, plant defense, and tolerance/sensitivity to abiotic stress all point to a fundamental role of splicing/AS in plant growth, development, and responses to external cues. Splicing factors affect the AS of multiple downstream target genes, thereby transferring signals to alter gene expression via splicing factor/AS networks. The last two to three years have seen an ever-increasing number of examples of functional AS. At a time when the identification of AS in individual genes and at a global level is exploding, this review aims to bring together such examples to illustrate the extent and importance of AS, which are not always obvious from individual publications. It also aims to ensure that plant scientists are aware that AS is likely to occur in the genes that they study and that dynamic changes in AS and its consequences need to be considered routinely.

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Section: Factors Involved In As Of R Genes and Plant Defensementioning

confidence: 99%

Alternative Splicing at the Intersection of Biological Timing, Development, and Stress Responses

2013

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Section: Effectors That Target De Novo Prr Biogenesismentioning

confidence: 99%

“…tomato (Pto) DC3000 is an mono-ADP-ribosyltransferase that specifically modifies several plant RNA binding proteins, such as GRP7 [15,16]. The action of HopU1 impedes their RNA-binding function and inhibits PTI [15,16]. Notably, GRP7 can bind mRNAs encoding the leucine-rich repeat (LRR)-RKs FLS2 and EFR (which are the PRRs for bacterial flagellin and EF-Tu, respectively), potentially contributing to the pathogen-induced translation of these mRNAs.…”

Section: Effectors That Target De Novo Prr Biogenesismentioning

confidence: 99%

Targeting of plant pattern recognition receptor-triggered immunity by bacterial type-III secretion system effectors

Macho

Zipfel

2015

Current Opinion in Microbiology

248

179

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“…Alternative splicing has recently been implicated as playing a major role in these processes during stresses, including disease, heat, drought, and others (Deom et al, 1987;Iida et al, 2004;Jeong et al, 2011;Kakumanu et al, 2012;Chang et al, 2014;Mandadi and Scholthof, 2015). Gene expression changes in splicing factors are a major factor in determining stress-induced alternative splicing changes (Yan et al, 2012;Leviatan et al, 2013;Staiger and Brown, 2013).…”

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Genome-Wide Analysis of Alternative Splicing during Development and Drought Stress in Maize

et al. 2015

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Alternative splicing plays a crucial role in plant development as well as stress responses. Although alternative splicing has been studied during development and in response to stress, the interplay between these two factors remains an open question. To assess the effects of drought stress on developmentally regulated splicing in maize (Zea mays), 94 RNA-seq libraries from ear, tassel, and leaf of the B73 public inbred line were constructed at four developmental stages under both well-watered and drought conditions. This analysis was supplemented with a publicly available series of 53 libraries from developing seed, embryo, and endosperm. More than 48,000 novel isoforms, often with stage-or condition-specific expression, were uncovered, suggesting that developmentally regulated alternative splicing occurs in thousands of genes. Drought induced large developmental splicing changes in leaf and ear but relatively few in tassel. Most developmental stage-specific splicing changes affected by drought were tissue dependent, whereas stage-independent changes frequently overlapped between leaf and ear. A linear relationship was found between gene expression changes in splicing factors and alternative spicing of other genes during development. Collectively, these results demonstrate that alternative splicing is strongly associated with tissue type, developmental stage, and stress condition.After transcription, the majority of eukaryotic premRNA is subjected to a series of posttranscriptional modifications, including the removal of introns to form a mature mRNA (Stamm et al., 2005). Although some introns are removed constitutively, many can be processed in a variety of alternative ways, including exon skipping, intron retention, alternative acceptor, alternative donor, and alternative position (change in both acceptor and donor positions; Lorkovic et al., 2000). These alternative splicing events form a crucial regulatory level and have the ability to alter an mRNA's stability, localization, and protein products. Alternative splicing events are controlled by a variety of cis-elements, including the presence of consensus splice sequences at the intron-exon border and intronic and exonic splicing enhancer sequences (Pertea et al., 2007). Trans-acting factors also exert a strong effect on splicing and are mostly composed of Ser/Arg-rich proteins, which typically promote intron removal, and heterogenous nuclear ribonucleoproteins, which typically inhibit it (Erkelenz et al., 2013). A host of other indirect factors can affect splicing, including transcription rate, methylation status, and any cellular conditions that alter RNA secondary structure (Kornblihtt et al

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Structure Function Analysis of an ADP-ribosyltransferase Type III Effector and Its RNA-binding Target in Plant Immunity

Cited by 89 publications

References 60 publications

Alternative Splicing at the Intersection of Biological Timing, Development, and Stress Responses

Alternative Splicing at the Intersection of Biological Timing, Development, and Stress Responses

Targeting of plant pattern recognition receptor-triggered immunity by bacterial type-III secretion system effectors

Genome-Wide Analysis of Alternative Splicing during Development and Drought Stress in Maize

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