Structure, function and applications of carbonic anhydrase isozymes

Hassan, Md. Imtaiyaz; Shajee, Bushra; Waheed, Abdül; Ahmad, Faizan; Sly, William S.

doi:10.1016/j.bmc.2012.04.044

Cited by 223 publications

(111 citation statements)

References 174 publications

(259 reference statements)

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“…The general function of carbonic anhydrase (CA) is to catalyze the reversible conversion of carbon dioxide and water to a bicarbonate ion and a proton [1][2][3]. Misregulation of this enzyme has been linked to many diseases, such as glaucoma, cancer, and epilepsy [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Determination of activities of human carbonic anhydrase II inhibitors from curcumin analogs

Aditama¹,

Eryanti²,

Mujahidin³

et al. 2017

Trop. J. Pharm Res

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Section: Introductionmentioning

confidence: 99%

“…Misregulation of this enzyme has been linked to many diseases, such as glaucoma, cancer, and epilepsy [4,5]. The isozyme CA-II is known to be one of the most efficient in CO 2 hydration [2]. Sulfonamide compounds, which are known as strong inhibitors of CA-II, have been used as commercial drugs to treat glaucoma [6].…”

Section: Introductionmentioning

confidence: 99%

Determination of activities of human carbonic anhydrase II inhibitors from curcumin analogs

Aditama¹,

Eryanti²,

Mujahidin³

et al. 2017

Trop. J. Pharm Res

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“…Besides, many salt-tolerant genes were cloned. Carbonic anhydrase (CA, EC 4.2.1.1) containing a zinc atom was cloned and identified to catalyze the reversible conversion between carbon dioxide and bicarbonate radical (CO 2 + H 2 O↔HCO 3¯ ) [6,7] , which plays an important role in many biological processes, such as ion exchange, respiration, pH stabilization, calcification, CO 2 capture, and photosynthesis [8][9][10] . Since 1933, when the CA gene was found in red blood cells, it has also been discovered in all types of mammalian histiocytes.…”

Section: Introductionmentioning

confidence: 99%

Cloning of SjCA gene and its expression analysis on upland cottons

Kong

Zhao

et al. 2016

JBEI

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Acquisition of salt-tolerant genes from exogenous plants to improve cotton salt resistance has always been a hotspot of research on cotton salt resistance. However, the information regarding the method of conversion of living cotton pollens by portable gene gun technology is still little. Complete sequence information of the Carbonic Anhydrase (CA) gene was obtained from NCBI database, and its full ORF length sequence was cloned by RT-PCR technology. After the construction of pBI121-CA::GFP fusion expression vector, we used cotton pollens from upland cotton varieties Y-2067, ZA-23, and GZ-2, which have weaker autofluorescence, to conduct the research on the transient expression of cotton pollens in vivo via particle bombardment (gene gun technology). The results indicated that green fluorescence enhancement of the three kinds of cotton pollens was realized after the CA gene transformation, meaning that the CA gene expression level was increased. Besides, the salt tolerance germination ability of transgenic T1 seeds was also improved. Our research initially established a transient expression system of cotton pollen in vivo via particle bombardment technology, laying the theoretical foundation for further research of cotton genetic transformation and creation of cotton salt-tolerant germplasm.

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“…Although structurally homologous, the inactivity of these CAs is due to the absence of one or more Zn-binding histidine residues (1, 3–6). The structure and function of CA isozymes have been extensively reviewed by Hassan et al, 2012 (7). …”

Section: Introductionmentioning

confidence: 99%

Carbonic Anhydrase IX as an Imaging and Therapeutic Target for Tumors and Metastases

Tafreshi

Lloyd

Bui

et al. 2013

Subcellular Biochemistry

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Carbonic anhydrase IX (CAIX) which is a zinc containing metalloprotein, efficiently catalyzes the reversible hydration of carbon dioxide. It is constitutively up-regulated in several cancer types and has an important role in tumor progression, acidification and metastasis. High expression of CAIX generally correlates with poor prognosis and is related to a decrease in the disease-free interval following successful therapy. Therefore, it is considered as a prognostic indicator in oncology. In this review, we describe CAIX regulation and its role in tumor hypoxia, acidification and metastasis. In addition, the molecular imaging of CAIX and its potential for use in cancer detection, diagnosis, staging, and for use in following therapy response is discussed. Both antibodies and small molecular weight compounds have been used for targeted imaging of CAIX expression. The use of CAIX expression as an attractive and promising candidate marker for systemic anticancer therapy is also discussed.

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Structure, function and applications of carbonic anhydrase isozymes

Cited by 223 publications

References 174 publications

Determination of activities of human carbonic anhydrase II inhibitors from curcumin analogs

Determination of activities of human carbonic anhydrase II inhibitors from curcumin analogs

Cloning of SjCA gene and its expression analysis on upland cottons

Carbonic Anhydrase IX as an Imaging and Therapeutic Target for Tumors and Metastases

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