Structure of the Crypt Epithelium in Human Palatine Tonsils

Perry, M. E.; Jones, Marilyn M.; Mustafa, Y

doi:10.3109/00016488809125005

Cited by 37 publications

(26 citation statements)

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“…O método de tratamento para tonsilite crônica caseosa, desenvolvido no presente trabalho, levou em consideração o desejo de se preservar as tonsilas palatinas que, como é sabido, constituem a primeira barreira de defesa de nosso organismo 5,6,15,16,17,18,19 . Nesta técnica, mais conservadora que a convencional com laser de CO 2, a interação laser-tecido ocorre apenas superficialmente, como explicado antes, alterando minimamente os centros germinativos de linfócitos ou mesmo a arquitetura tridimensional das tonsilas 21 .…”

Section: Discussionunclassified

“…A tonsila palatina é o único órgão linfóide em contato direto com o meio ambiente 4,5,15,16 , onde, cada vez mais, os indivíduos são expostos a um crescente número de poluentes, vírus, bactérias, etc. É revestida por epitélio plano estratificado, que sofre invaginações, formando as criptas 4,16,17 . O epitélio de revestimento das criptas é reticulado e constitui-se em uma barreira mecânica à propagação de infecções 4,15,16,18,19 .…”

Section: Introductionunclassified

“…Conclusion: We conclude this to be a safe and efficient method, able to be performed in the ambulatory under topic anesthesia; therefore, permitting to the patients immediate return to their activities. 4,6,15,16,17 . Na Foto 1 é apresentada uma micrografia (aumento 132 vezes), evidenciando a estrutura de criptas e centros germinativos de uma tonsila normal.…”

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Criptolise por coagulação com laser de CO2 em tonsilite crônica caseosa: método conservador e resultados

Passos¹,

Olveira²,

Nicola³

et al. 2002

Rev. Bras. Otorrinolaringol.

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Introdução:A criptolise convencional com laser CO 2 tem sido realizada com sucesso. Neste caso, um volume considerável de tecido é removido sem preocupação com possíveis reduções das funções das tonsilas. No presente trabalho propomos um método de criptolise com laser de CO 2 , alternativo, para tonsilites crônicas caseosas, com o qual o efeito desejado é obtido apenas através da coagulação pelo laser e não pela volatilização de tecidos. A preservação da tonsila é otimizada. Forma de Estudo: Clínico prospectivo. Objetivos: Apresentar uma técnica modificada de criptolise com laser de CO 2 que iniba a retenção de cáseo, preservando ao máximo o parênquima tonsilar. Material e Método: As criptolises foram realizadas em um grupo de trinta e um indivíduos portadores de tonsilite crônica caseosa, com grande eliminação de cáseo e demais sintomas associados. Os pacientes foram selecionados no ambulatório de ORL HC-UNICAMP. Utilizamos 6 W de laser CO 2 em modo contínuo, desfocado, em varredura (Swiftlase) em torno da abertura das criptas e, após, sobre toda a superfície da tonsila, produzindo apenas coagulação da superfície. Para desaparecimento dos sintomas foram necessárias, em média, sete aplicações, repetidas a cada três semanas. Resultados: A técnica proposta foi efetiva em 87% dos casos. Nos 13% restantes houve, também, a necessidade de volatilização de regiões de confluência de criptas. O tempo de seguimento foi de dois anos, sem evidências de complicações. Conclusão: Concluímos ser esta uma técnica segura e eficiente, podendo ser realizada ambulatorialmente sob anestesia tópica, permitindo ao paciente retorno imediato às suas atividades.

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Section: Discussionunclassified

Section: Introductionunclassified

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Criptolise por coagulação com laser de CO2 em tonsilite crônica caseosa: método conservador e resultados

Passos¹,

Olveira²,

Nicola³

et al. 2002

Rev. Bras. Otorrinolaringol.

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“…The structure of tonsillar crypt epithelium is different from that of the stratified squamous epithelium of the oral mucosa (Olfih and Everett 1975;Howie 1980;Perry et al 1988;. The main difference arises from the migration of various kinds of lymphoid cells (lymphocytes, macrophages, denritic cells, granulocytes, and plasma cells) into the intercellular space of the keratinocytes.…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural study of postnatal development of the tonsillar crypt epithelium of the musk shrew, Suncus murinus

Tohya¹,

Kimura²

1992

Anat Embryol

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An ultrastructural study was made of the postnatal development of the tonsillar crypt epithelium in the musk shrew, Suncus murinus. On day 3 after birth, a particular kind of large lymphoid cell was first seen to move through the basement membrane into the epithelium. The next migration was that of lymphocytes, which passed through holes in the basement membrane. On days 5 to 7, the lymphocytes formed clusters, and pale epithelial cells of low electron density appeared. The cell clusters and pale epithelial cells fused on day 10. By day 14, these epithelial cells extended cytoplasmic projections to the surface of the epithelium, which had many heterophagic vacuoles and some microvilli-like structures. These findings suggest that the lymphoepithelial relationship is important for the organization of the immunological microenvironment in tonsillar crypt epithelium of the neonatal musk shrew.

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“…In tonsillar tissue p16 staining is greatest in the areas involved in antigen filtering, namely the reticulated epithelium of the tonsillar crypts [12,13]. Various studies have commented on the histological similarities between lymphoepithelial cysts and tonsillar crypt epithelium [14][15][16], leading to the postulation that the former may develop from an embryolgically displaced latter or even from dislodged crypt epithelium during bouts of tonsillitis [16,17].…”

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Cystic Neck Masses – A diagnostic and management challeng

Amer¹,

Choudhury²,

Falzon³

et al. 2014

SAJ Case Reports

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We discuss the case of a 41 year old gentleman referred to the one-stop clinic with a neck mass. An ultrasound scan and FNAC and subsequent excision biopsy showed a squamous lined cystic lymph node, with some focal positivity for cytoplasmic p16 staining. The pathology was potentially in keeping with a benign cystic lesion however a metastatic SCC could not be excluded.Cervical metastasis is often the only presenting feature in patients with squamous cell carcinoma of the head and neck (HNSCC) [1]. These metastatic foci frequently undergo cystic degeneration, and may be difficult to distinguish from other benign cystic lymphoepithelial lesions of the head and neck [2]. Cervical metastates from primaries in the oropharynx have been shown to be more likely to undergo these cystic changes in comparison to squamous cell carcinoma from other head and neck sites [3][4][5].During the investigative work up of these cases, fine needle aspiration for cytopathology (FNAC) may be performed. However, the results obtained are not always diagnostic. To increase the specificity of FNAC, immunohistochemistry for p16 is often performed, as p16 overexpression has been shown to act as a surrogate marker of Human Papilloma Virus (HPV) associated HNSCC [6] HPV, particularly subtype 16, has been shown to be a causative agent in a subset of HNSCC [7,8]. The majority of these HPV related carcinomas localise to the tonsil; which in turn is the most common site for primary tumour in the context of cystic metastasis [3,9]. Hence, previous studies have shown p16 positivity to thus correlate with oropharyngeal primary tumours [10].Nonetheless, the value of this marker in the differentiation between benign and malignant cystic lesions of the head and neck remains unclear. A case series by Pai et al showed that p16 staining was negative in all aspirates of branchial cleft cysts sampled (n = 4), and positive in 36% of the aspirates from malignant SCC cysts (n = 11) [11]. In contrast, a series reported by Cao et al also evaluating p16 staining in aspirates from cystic neck lesions, reported that up to 42% of benign lymphoepithelial lesions (n = 12) and 19% of malignant squamous lesions (n = 16) were positive for p16 [2]. Cervical metastasis is often the only presenting feature in patients with squamous cell carcinoma of the head and neck (HNSCC). These metastases frequently undergo cystic degeneration, and may be difficult to distinguish from other benign cystic squamous lesions of the head and neck. Fine needle aspiration for cytopathology (FNAC) is frequently performed, but the results obtained may not be conclusive. P16 immunohistochemistry may be carried out. However, the value of this test in differentiating between benign and malignant cystic lesions of the head and neck remains unclear. Cystic Neck Masses -A Diagnostic and Management ChallengeAbstract

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Structure of the Crypt Epithelium in Human Palatine Tonsils

Cited by 37 publications

References 3 publications

Criptolise por coagulação com laser de CO2 em tonsilite crônica caseosa: método conservador e resultados

Criptolise por coagulação com laser de CO2 em tonsilite crônica caseosa: método conservador e resultados

Ultrastructural study of postnatal development of the tonsillar crypt epithelium of the musk shrew, Suncus murinus

Cystic Neck Masses – A diagnostic and management challeng

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