Structure of the lens and its associations with the visual quality

Ruan, Xiaoting; Liu, Zhenzhen; Luo, Lixia; Liu, Yizhi

doi:10.1136/bmjophth-2020-000459

Cited by 33 publications

(17 citation statements)

References 60 publications

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“…The present data shows a weak association between the halo size and internal SA at both low photopic and mesopic luminance levels. In the human eye, there is a compensation mechanism between corneal aberrations and lens aberrations (25). We speculate that the negative (rather than positive) correlation between halo size and internal SA can be attributed to the compensation mechanism originating from internal aberrations.…”

Section: Discussionmentioning

confidence: 78%

Evaluation of Disk Halo Size and Identification of Correlated Factors in Myopic Adults

Zhao

Han

et al. 2022

Front. Med.

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This study aimed to evaluate glare source-induced disk halo size and assess its correlation with higher-order aberrations (HOAs), pupillometry findings, and contrast sensitivity in myopic adults (aged 23.8 ± 4.4 years). In this cross-sectional study, 150 eyes of 150 patients were assessed. All patients underwent routine ophthalmic examinations, wavefront aberrometry, halo size measurement, dynamic pupillometry, and contrast sensitivity tests. Spearman's correlation analysis and independent sample t-tests were performed for data analysis. The mean halo radius was 82.5 ± 21.8 and 236.7 ± 52.2 arc min at 5 and 1 cd/m2 luminance levels, respectively. The values were inversely correlated with internal spherical aberration (SA) (r = −0.175, p = 0.032 and r = −0.241, p = 0.003, respectively), but not correlated with spherical equivalent (SE, both p > 0.05). Positive correlations were observed between halo radius and pupil size, contraction amplitude, and dilation speed during pupillary light reflex. Halo radii at 5 and 1 cd/m2 luminance levels were not significantly correlated with the area under the log contrast sensitivity function (r = −0.093, p = 0.258 and r = −0.149, p = 0.069, respectively). The mean halo radius was not clinically different between myopic and healthy eyes at 5 cd/m2 luminance level and did not differ significantly between the high and low-to-moderate myopia at 5 and 1 cd/m2 luminance levels (all p > 0.05). According to a stepwise linear regression model, the internal SA had a negative effect on the halo radius under low photpic condition; the average pupil diameter, internal SA and corneal HOAs played a large role in determining the halo radius under mesopic condition.

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Section: Discussionmentioning

confidence: 78%

Evaluation of Disk Halo Size and Identification of Correlated Factors in Myopic Adults

Zhao

Han

et al. 2022

Front. Med.

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“…The eye seeing problems are important because the position of the lens center must be on the anatomical optical axis of the eye [ 12 ].…”

Section: The Process Of Manufacturing Spectacles Frames Using 3d Prin...mentioning

confidence: 99%

Innovation Process for Optical Face Scanner Used to Customize 3D Printed Spectacles

2022

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Many people for different reasons end up wearing glasses to correct their vision. From time immemorial, there has been an unquestionable ability to associate people with glasses. Designing the glasses according to the physiognomy of each person opens a new path for a completely new optical experience. The frames are designed to fit perfectly on the face, are comfortable on the nose, and are positioned at an optimal distance from the cheeks and eyelashes. Three-dimensional printing technology offers the possibility to customize any form of glasses at a low cost with average quality. In this type of technology, the printer receives a digitized model of the spectacle frame (usually in STL file format) that must meet the parameters related to the wearer’s anatomy. Therefore, this paper presents an innovative process, an optical method used to scan the wearer’s face to design a parameterized design of the spectacle frames. The procedure has a measurement phase for quantifying the anatomical features of the wearer’s face, a para-metric design phase of the glasses for adjusting the design parameters according to the anatomical characteristics, and a manufacturing phase in which the custom eyeglass frame will be manufactured using 3D printing technology. The aim of this study was to create an innovative process that could be tested as an educational 3D printing system that could be used by undergraduate students (studying under an optometry program), a process that would begin at optometric prescription stage and can be used in the educational laboratory of the Department of Mechatronics and Precision Mechanics from the Politehnica University of Bucharest. Using this method we obtained a custom spectacle frame that can be prototyped using 3D printing. The 3D-printed polylactic acid (PLA) frames are lightweight, flexible, durable, and the innovative photogrammetry process gives designers the ability to create custom designs that cannot be created with traditional manufacturing techniques.

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“…The lens is a biconvex transparent tissue situated between the iris and the vitreous, composed of a single layer of epithelial cells under the anterior capsule and the enormous lens fibers differentiated from epithelial cells (Ruan et al, 2020). Epithelial cells at the lens equator region migrate laterally toward the equator, where they transform into differentiating fiber cells and finally turn into mature fiber cells through extensive cell elongation.…”

Section: Introductionmentioning

confidence: 99%

Mutations of CX46/CX50 and Cataract Development

Shi

Yang

2022

Front. Mol. Biosci.

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Cataract is a common disease in the aging population. Gap junction has been considered a central component in maintaining homeostasis for preventing cataract formation. Gap junction channels consist of connexin proteins with more than 20 members. Three genes including GJA1, GJA3, and GJA8, that encode protein Cx43 (connexin43), Cx46 (connexin46), and Cx50 (connexin50), respectively, have been identified in human and rodent lens. Cx46 together with Cx50 have been detected in lens fiber cells with high expression, whereas Cx43 is mainly expressed in lens epithelial cells. Disrupted expression of the two connexin proteins Cx46 and Cx50 is directly related to the development of severe cataract in human and mice. In this review article, we describe the main role of Cx46 and Cx50 connexin proteins in the lens and the relationship between mutations of Cx46 or Cx50 and hereditary cataracts. Furthermore, the latest progress in the fundamental research of lens connexin and the mechanism of cataract formation caused by lens connexin dysfunction are summarized. Overall, targeting connexin could be a novel approach for the treatment of cataract.

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Structure of the lens and its associations with the visual quality

Cited by 33 publications

References 60 publications

Evaluation of Disk Halo Size and Identification of Correlated Factors in Myopic Adults

Evaluation of Disk Halo Size and Identification of Correlated Factors in Myopic Adults

Innovation Process for Optical Face Scanner Used to Customize 3D Printed Spectacles

Mutations of CX46/CX50 and Cataract Development

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