Structure-Toxicity Relationships of Substituted Phenothiazines

Effect of edetate disodium on goldfish membrane

“…Levy and coworkers (4, 5) utilized goldfish to study the effects of surfactants on the absorption of alcohols and barbiturates. Nightingale et al (6) used goldfish to assess structure-toxicity relationships of some substituted phenothiazines. Feldman et al (7) used goldfish to study various local anesthetic agents and found an apparent relationship between the minimum effective concentration of drug to produce a response in goldfish and the minimum blocking concentration of these agents in isolated nerve or muscle fibers (8).…”