Vision-and-language navigation (VLN) is a trending topic which aims to navigate an intelligent agent to an expected position through natural language instructions. This work addresses the task of VLN from a previouslyignored aspect, namely the spatial route prior of the navigation scenes. A critically enabling innovation of this work is explicitly considering the spatial route prior under several different VLN settings. In a most information-rich case of knowing environment maps and admitting shortestpath prior, we observe that given an origin-destination node pair, the internal route can be uniquely determined. Thus, VLN can be effectively formulated as an ordinary classification problem over all possible destination nodes in the scenes. Furthermore, we relax it to other more general VLN settings, proposing a sequential-decision variant (by abandoning the shortest-path route prior) and an exploreand-exploit scheme (for addressing the case of not knowing the environment maps) that curates a compact and informative sub-graph to exploit. As reported by [34], the performance of VLN methods has been stuck at a plateau in past two years. Even with increased model complexity, the state-of-the-art success rate on R2R validation-unseen set has stayed around 62% for single-run and 73% for beam-search. We have conducted comprehensive evaluations on both R2R and R4R, and surprisingly found that utilizing the spatial route priors may be the key of breaking above-mentioned performance ceiling. For example, on R2R validation-unseen set, when the number of discrete nodes explored is about 40, our single-model success rate reaches 73%, and increases to 78% if a Speaker model is ensembled, which significantly outstrips previous state-ofthe-art VLN-BERT with 3 models ensembled.