Structures, hydrolysis, stabilities of palladium(II) complexes containing biologically active ligands and species distribution in aqueous solution

İnci, Duygu; Aydın, Rahmiye

doi:10.1016/j.molstruc.2019.03.041

Cited by 9 publications

(6 citation statements)

References 49 publications

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“…The protonation constants of 4,7-dmphen, asp, and glu and their stability constants of the (1:1) and (1:1:1) Ni(II) and Cu(II) complexes have been computed with the BEST program (15) and the species distribution of (1:1) and (1:1:1) Ni(II) and Cu(II) complexes in these systems was assessed using the SPE program (15). Thus, the tendency of Ni(II) and Cu(II) ions and 4,7-dmphen, asp, and glu to form the (1:1) and ( 1 processing were similar to those described in our previous studies (9)(10)(11)(12)(13)(14).…”

Section: Introductionsupporting

confidence: 88%

“…The relative stability of the (1:1:1) complexes compared to those of the corresponding (1:1) species might be assessed in distinct ways. In most cases Δlog10K values are employed (9)(10)(11). The Δlog10K values have been computed with the Equation 11 and given in Table 3.…”

Section: Protonation Constants Of 47-dmphen/acidic Amino Acidsmentioning

confidence: 99%

“…Many studies in the literature have focused on experimentally and computationally determining the protonation constant of ligands and their stability constants of the complexes formed with metal ions (6)(7)(8). Recently, we have reported that (1:1) and (1:1:1) palladium(II) and copper(II) complexes of amino acids, 1,10-phenanthroline, and derivatives in aqueous solution (9)(10)(11)(12)(13)(14). As a continuation of these studies, the protonation constants of the 4,7dmphen, asp and glu ( Figure 1) and their stability constants of (1:1) and (1:1:1) Ni(II) and Cu(II) complexes have been computed by potentiometric titration methods (T = 298.15 K and I = 0.1 M KCl).…”

Section: Introductionmentioning

confidence: 99%

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EQUILIBRIUM STUDIES ON Ni(II) and Cu(II) COMPLEXES with 4,7- DIMETHYL-1,10-PHENANTHROLINE and ACIDIC AMINO ACIDS in AQUEOUS SOLUTION

İnci

2020

Journal of the Turkish Chemical Society Section A: Chemistry

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The aim of this study is to determine the protonation constants of selected ligands {4,7dimethyl-1,10-phenanthroline (4,7-dmphen), aspartic acid (asp), and glutamic acid (glu)} and their stability constants of (1:1) and (1:1:1) complexes with Ni(II) and Cu(II) ion have been determined I = 0.1 M KCl and T = 298.15 K. The protonation constants of the 4,7-dmphen, asp, and glu and their stability constants of the (1:1) and (1:1:1) Ni(II) and Cu(II) complexes have been computed performing BEST program. Moreover, SPE program has been used to determine the distribution of the species occurred in aqueous solution medium. The stability constants of the (1:1:1) Ni(II) and Cu(II) complexes are compared with those of the corresponding to the stability of the (1:1) Ni(II) and Cu(II) complexes with regard to Δlog K values.

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Section: Introductionsupporting

confidence: 88%

Section: Protonation Constants Of 47-dmphen/acidic Amino Acidsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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EQUILIBRIUM STUDIES ON Ni(II) and Cu(II) COMPLEXES with 4,7- DIMETHYL-1,10-PHENANTHROLINE and ACIDIC AMINO ACIDS in AQUEOUS SOLUTION

İnci

2020

Journal of the Turkish Chemical Society Section A: Chemistry

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“…The metal precursors [PtCl 2 (phen)] and [PdCl 2 (phen)] used in the synthesis of complexes I and II were prepared as previously reported in the literature [ 52 , 53 , 54 ]. All reagents and solvents were purchased from Merck and were used as received.…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial Resistance Challenged with Platinum(II) and Palladium(II) Complexes Containing 1,10-Phenanthroline and 5-Amino-1,3,4-Thiadiazole-2(3H)-Thione in Campylobacter jejuni

et al. 2022

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This work describes the synthesis and characterization of two metal complexes of the type [M(L1)2(phen)], where M = Pt2+ (complex I) or Pd2+ (complex II), L1 = 5-amino-1,3,4-thiadiazole-2(3H)-thiolate and phen = 1,10-phenanthroline. The in vitro antibacterial activity of these complexes was investigated in isolation and synergistically with ciprofloxacin (CIP) and erythromycin (ERY) in three strains of Campylobacter jejuni (MIC = 32 mg/L for CIP and ERY), selected from a bank of 235 strains representative of three poultry exporting states of the country (A, B and C), previously analyzed for epidemiology and resistance to CIP and ERY. A total of 53/235 (22.55%) strains showed co-resistance to CIP and ERY. Isolated resistance to CIP was higher than to ERY. Epidemiological analysis showed that resistance to CIP was more evident in state B (p < 0.0001), as well as a higher susceptibility to ERY in state C (p = 0.0028). Co-resistance was expressive in state A and in the spring and fall seasons. The evaluation of I alone and in synergy with CIP and ERY found values up to 0.25 mg/L not significant for ERY. Complex II did not show an antimicrobial effect on the three strains of tested C. jejuni. The effect provided by complex I represents a promising alternative for control of resistant strains of C. jejuni.

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“…Unprotected amino acids have been previously shown to coordinate to Pd, so we hypothesize that unprotected tyrosine bound to the catalyst and shuts down the reaction. [36,37] Given these results, the remaining model studies were completed with Boc-DIT only.…”

Section: Survey Of Tyrosine Derivativesmentioning

confidence: 99%

Chemical Modification of Silk Proteins via Palladium‐Mediated Suzuki−Miyaura Reactions

Santen,

Owens,

Echague

et al. 2023

Macro Chemistry & Physics

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Suzuki−Miyaura cross‐coupling reactions are used to modify the tyrosine residues on Bombyx mori silkworm silk proteins using a water‐soluble palladium catalyst. First, model reactions using tyrosine derivatives are screened to determine optimal reaction conditions. For these reactions, a variety of aryl boronic acids, solvents, buffers, and temperature ranges are explored. Qualitative information on the reaction progress is collected via high‐performance liquid chromatography (HPLC), mass spectrometry (MS), and nuclear magnetic resonance (NMR). Optimized reactions are then applied to silk proteins. It is demonstrated the ability to modify silk fibroin in solution by first iodinating the tyrosine residues on the protein, and then carrying out Suzuki‐Miyaura reactions with a variety of boronic acid derivatives. Modification of silk is confirmed with NMR, ion‐exchange chromatography (IEC), UV‐vis, and infrared spectroscopy (IR).

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Structures, hydrolysis, stabilities of palladium(II) complexes containing biologically active ligands and species distribution in aqueous solution

Cited by 9 publications

References 49 publications

EQUILIBRIUM STUDIES ON Ni(II) and Cu(II) COMPLEXES with 4,7- DIMETHYL-1,10-PHENANTHROLINE and ACIDIC AMINO ACIDS in AQUEOUS SOLUTION

EQUILIBRIUM STUDIES ON Ni(II) and Cu(II) COMPLEXES with 4,7- DIMETHYL-1,10-PHENANTHROLINE and ACIDIC AMINO ACIDS in AQUEOUS SOLUTION

Antimicrobial Resistance Challenged with Platinum(II) and Palladium(II) Complexes Containing 1,10-Phenanthroline and 5-Amino-1,3,4-Thiadiazole-2(3H)-Thione in Campylobacter jejuni

Chemical Modification of Silk Proteins via Palladium‐Mediated Suzuki−Miyaura Reactions

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