Structures of New Dammarane-Type Triterpene Saponins from the Flower Buds of Panax notoginseng and Hepatoprotective Effects of Principal Ginseng Saponins

Yoshikawa, Masayuki; Morikawa, Toshio; Kashima, Yousuke; Ninomiya, Kiyofumi; Matsuda, Hisashi

doi:10.1021/np030015l

Cited by 163 publications

(102 citation statements)

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“…Preliminary phytochemical screening indicated the presence of tannins, saponins and flavonoids (Bafor et al 2009;Adebayo et al 2009). The antioxidant and hepatoprotective activities of flavanoids (Yoshikawa et al 2003) and Saponins (Baek et al 1996) are well known. This goes to strengthen our belief that the hepatoprotective activity of the extract may in also be due to the presence of Flavonoid and Saponin compounds.…”

Section: Sacrifice Of Animalsmentioning

confidence: 99%

Stem Bark Extracts of Ficus exasperata protects the Liver against Paracetamol induced toxicity in Wistar Rats

Enogieru¹,

Charles²,

Omoruyi³

et al. 2015

Journal of Applied Sciences and Environmental Management

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ABSTRACT:Ficus exasperata is an important medicinal plant with a wide geographical distribution in Africa particularly in Nigeria. In this study, aqueous stem bark extracts of Ficus exasperata were administered to investigate its hepatoprotective effects on Paracetamol induced liver toxicity in Wistar rats. A total of Twenty Five Wistar rats were randomly divided into five groups labeled A-E and kept in a well ventilated room. Group A served as control and were treated with distilled water. Rats in groups B-E were all treated with Paracetamol (800mg/kg body weight) but rats in group C, D and E were however pretreated with Silymarin (50 mg/kg bw), 100mg/kg bw aqueous stem bark extracts of Ficus exasperata and 200mg/kg bw aqueous stem bark extracts of Ficus exasperata respectively one hour before Paracetamol administration for fourteen days. Animals were sacrificed twenty four hours after the last treatment. Blood samples were collected into heparinized bottles for biochemical estimation of liver enzymes and the liver was harvested for routine histological examination. Paracetamol produced significant changes in biochemical parameters (increases in serum Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP), with a reduction in Total protein) and Liver histology (damage to hepatocytes). Pretreatment with Silymarin and aqueous stem bark extracts of Ficus exasperata significantly prevented the biochemical and histological changes induced by Paracetamol in the liver. In conclusion, our histological and biochemical findings indicate that aqueous stem bark extracts of Ficus exasperata possesses hepatoprotective properties. © JASEM http://dx.doi.org/10.4314/jasem.v19i1.20

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Section: Sacrifice Of Animalsmentioning

confidence: 99%

Stem Bark Extracts of Ficus exasperata protects the Liver against Paracetamol induced toxicity in Wistar Rats

Enogieru¹,

Charles²,

Omoruyi³

et al. 2015

Journal of Applied Sciences and Environmental Management

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“…The tubers of this plant have been used as a traditional Chinese medicine for the treatment of asthma, neurasthenia, and chronic hepatitis. In the course of our studies on bioactive constituents from Chinese natural medicines, [2][3][4][5][6][7][8][9][10][11][12] we found that the methanolic extract of this natural medicine showed an antiallergic activity on ear passive cutaneous anaphylaxis reactions in mice. From the methanolic extract, three dihydrophenanthrenes and a dihydrostilbene named gymconopins A-D were isolated together with 10 known phenanthrene and stilbene constituents and their inhibitory effects on antigen-induced degranulation in RBL-2H3 cells were characterized.…”

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confidence: 95%

Bioactive Constituents from Chinese Natural Medicines. XVII. Constituents with Radical Scavenging Effect and New Glucosyloxybenzyl 2-Isobutylmalates from Gymnadenia conopsea

et al. 2006

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The methanol-eluted fraction of the methanolic extract from the tubers of Gymnadenia conopsea was found to show radical scavenging activities for DPPH and super oxide anion ( . O 2 ؊ ) radicals. Three new glucosyloxybenzyl 2-isobutylmalates, gymnosides VIII, IX, and X, were isolated from this natural medicine together with 58 known constituents. The stereostructures of gymnosides were elucidated on the basis of chemical and physicochemical evidence. In addition, the phenanthrene and dihydrostilbene constituents showed radical scavenging activities and suggested the following structural requirements on radical scavenging activities; a) phenanthrenes: 1) dihydrogenation at the 9,10-positions enhances the activities, 2) the 1 or 3-p-hydroxybenzyl group enhances the activities; b) dihydrostilbenes: 1) methylation of the 3-position reduces the activities, 2) the 2-and/or 6-p-hydroxybenzyl groups enhance the activities.

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“…These phytochemicals are well documented for their hepatoprotective action [19,20] . Hence, from this study, it can be concluded that methanolic extract of leaves of E. monogynum possesses hepatoprotective activity against paracetamol induced toxicity in rats.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of leaves of Erythroxylum monogynum Roxb. on paracetamol induced toxicity

Syed

Namdeo

2013

Asian Pacific Journal of Tropical Biomedicine

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Structures of New Dammarane-Type Triterpene Saponins from the Flower Buds of Panax notoginseng and Hepatoprotective Effects of Principal Ginseng Saponins

Cited by 163 publications

References 36 publications

Stem Bark Extracts of <i>Ficus exasperata</i> protects the Liver against Paracetamol induced toxicity in Wistar Rats

Stem Bark Extracts of <i>Ficus exasperata</i> protects the Liver against Paracetamol induced toxicity in Wistar Rats

Bioactive Constituents from Chinese Natural Medicines. XVII. Constituents with Radical Scavenging Effect and New Glucosyloxybenzyl 2-Isobutylmalates from Gymnadenia conopsea

Hepatoprotective effect of leaves of Erythroxylum monogynum Roxb. on paracetamol induced toxicity

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