Struggling toward reward: Recent experience of anhedonia interacts with motivation to predict reward pursuit in the face of a stressful manipulation

Bryant, Jessica; Winer, E. Samuel; Salem, Taban; Nadorff, Michael R.

doi:10.1371/journal.pone.0173439

Cited by 17 publications

(10 citation statements)

References 42 publications

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“…“Loss of satisfaction” (“I am dissatisfied or bored with everything”; BDI-4) and “loss of interest in people” (BDI-12) were also identified as core symptoms in the depressive symptom–patient activation network. This finding supports previous studies, 34 , 35 which argue that the affective symptoms of depression such as anhedonia can thwart even small behavioral changes needed to manage chronic medical illnesses. Interestingly, previous studies have shown that these affective symptoms of depression appear to be particularly cardiotoxic.…”

Section: Discussionsupporting

confidence: 91%

A Network Analysis of the Association Between Depressive Symptoms and Patient Activation Among Those With Elevated Cardiovascular Risk

Lee

Wolever

Yang

et al. 2022

Glob Adv Health Med

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Background Network analysis provides a new method for conceptualizing interconnections among psychological and behavioral constructs. Objective We used network analysis to investigate the complex associations between depressive symptoms and patient activation dimensions among patients at elevated risk of cardiovascular disease. Methods This secondary analysis included 200 patients seen in primary care clinics. Depressive symptoms were assessed using the 21-item Beck Depression Inventory. Patient activation was measured using the 13-item Patient Activation Measure. Glasso networks were constructed to identify symptoms/traits that bridge depressive symptoms and patient activation and those that are central within the network. Results “Self-dislike” and “confidence to maintain lifestyle changes during times of stress” were identified as important bridge pathways. In addition, depressive symptoms such as “punishment feelings,” “loss of satisfaction,” “self-dislike,” and “loss of interest in people” were central in the depressive symptom–patient activation network, meaning that they were most strongly connected to all other symptoms. Conclusions Bridge pathways identified in the network may be reasonable targets for clinical intervention aimed at disrupting the association between depressive symptoms and patient activation. Further research is warranted to assess whether targeting interventions to these central symptoms may help resolve other symptoms within the network.

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Section: Discussionsupporting

confidence: 91%

A Network Analysis of the Association Between Depressive Symptoms and Patient Activation Among Those With Elevated Cardiovascular Risk

Lee

Wolever

Yang

et al. 2022

Glob Adv Health Med

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“…For example a recent study in adults examining The Effort-Expenditure for Rewards Task (EEfRT) [52] has found that at low levels of anhedonia, action orientation (a motivation factor) was associated with effort for reward, but this relationship was not present at high levels of anhedonia. Thus, at low levels of anhedonia, action orientation acted as a buffer against stress, but at high levels, anhedonia debilitated action orientation so that it was no longer a promotive factor [53]*. In our recent study with adolescents at high risk of depression compared to controls we also measured effort but using button presses to win chocolate taste and avoid an unpleasant taste using this method we did not find behavioural differences in effort between groups.…”

Section: Anhedonia and Physical Effort In Adolescent Depressionmentioning

confidence: 84%

Linking anhedonia symptoms with behavioural and neural reward responses in adolescent depression

McCabe

2018

Current Opinion in Behavioral Sciences

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Adolescence is a period of change that crucially increases vulnerability to depression. Studies report blunted neural responses to reward that relate to positive affect and depression symptoms in adolescents. However how these results relate to the symptom of anhedonia in adolescents is not entirely clear. Anhedonia is not a unitary construct, but is described as having different processes (e.g. wanting vs. liking) each underpinned by different neurobiological pathways. Current studies report inconsistencies in findings when trying to relate reward processing at the behavioural and neural level with symptoms. One reason for this is the lack of specificity of clinical, behavioural and neural tasks for measuring reward in depression. Links between the experience of anhedonia in adolescent depression and the behavioural and neural measures of reward could be improved with more detailed questionnaires, more detailed measurements of the components of reward for e.g. decreased motivation/effort and more ecologically valid tasks relevant to adolescents, in the MRI scanner. Prevalence of adolescent depression Major Depressive Disorder (MDD) is characterized by persistent sadness, loss of interest or pleasure, feelings of worthlessness or guilt, sleep disturbances, poor concentration and suicidal thoughts. The World Health Organisation reports that depression is the predominant cause of illness and disability for both boys and girls aged 10 to 19 years [1]. As adolescence is a time of physical, social and psychological change, it is easy to see how this could contribute to mental health problems. Early-onset adolescent depression has a detrimental impact on normal development and leads to poorer outcomes in adulthood. Harrington et al., found that 60% of adults with adolescent onset depression experienced one or more episodes of MDD in adulthood compared to 27% in the control group [2]. Additionally a significant increased risk of later anxiety disorder, nicotine dependence,

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“…Recent changes in anhedonia that include loss of interest or pleasure may be specific to individuals avoiding positivity 4,12,13,70. Thus, avoidance of reward is a crucial candidate variable for future research that will unpack how and why individuals develop and maintain anhedonic symptoms.…”

Section: Moving Forward With Anhedonia Research: the Challenge Of Rewmentioning

confidence: 99%

<p>Conceptualizing anhedonias and implications for depression treatments</p>

Winer¹,

Jordan²,

Collins³

2019

PRBM

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Anhedonia has been implicated as a core symptom of depression and schizophrenia, and studying anhedonia has yielded a wide array of important findings aiding the understanding and identification of psychological disorders. However, anhedonia is a complex and multifaceted construct; indeed, the term anhedonia has been defined in psychological and psychiatric research as many different concepts, a number of which are theoretically and methodologically independent of one another. In this review alone, we discuss research that separates social aspects of anhedonia from the physical contexts of anhedonia, with the former emphasizing interpersonal relationships as important to anhedonic symptoms, and the latter emphasizing biological and brain-related impairment as potential causes of chronic anhedonia states. We highlight research that distinguishes between interest in (wanting) or experience of (liking) potential pleasure as definitions of anhedonia and also disambiguate methodologically and theoretically distinct ways of assessing 1) trait-level dispositional tendencies, 2) state-level cross-sectional assessments, and 3) symptom-based recent changes from baseline, all of which have been used to indicate anhedonia. Lastly, we describe cutting-edge translations of basic anhedonia research into treatment and discuss how different conceptualizations of anhedonia, guided by recent theoretical and methodological advances, have begun to usher in a science of anhedonia that is consistent with increasingly personalized assessment and treatment. We conclude with a note for future research, emphasizing that continued application of theoretically based operationalizations of anhedonia and sound design are paramount to continue the recent progress toward meaningful and specific use of the anhedonia construct in clinical research.

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Struggling toward reward: Recent experience of anhedonia interacts with motivation to predict reward pursuit in the face of a stressful manipulation

Cited by 17 publications

References 42 publications

A Network Analysis of the Association Between Depressive Symptoms and Patient Activation Among Those With Elevated Cardiovascular Risk

A Network Analysis of the Association Between Depressive Symptoms and Patient Activation Among Those With Elevated Cardiovascular Risk

Linking anhedonia symptoms with behavioural and neural reward responses in adolescent depression

<p>Conceptualizing anhedonias and implications for depression treatments</p>

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