Strychnos nux-vomica Extract and Its Ultra-High Dilution Reduce Voluntary Ethanol Intake in Rats

Sukul, Nirmal Chandra; Ghosh, Souvik; Sinhababu, S. P.; Sukul, Anirban

doi:10.1089/107555301750164280

Cited by 33 publications

(23 citation statements)

References 8 publications

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“…Sukul et al 21,22 observed that Nux vomica 30CH, administered orally, significantly reduces the duration of ethanol-induced loss of the righting reflex in albino mice. The mice were intraperitoneally administered a 25% ethanol solution, in a dose of 4 grams per kilogram of body weight, 6 h after treatment with Nux 30CH.…”

Section: Catalepsy and Convulsion Modelsmentioning

confidence: 99%

Assays of homeopathic remedies in rodent behavioural and psychopathological models

et al. 2009

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The first part of this paper reviews the effects of homeopathic remedies on several models of anxiety-like behaviours developed and described in rodents. The existing literature in this field comprises some fifteen exploratory studies, often published in non-indexed and non-peer-reviewed journals. Only a few results have been confirmed by multiple laboratories, and concern Ignatia, Gelsemium, Chamomilla (in homeopathic dilutions/potencies). Nevertheless, there are some interesting results pointing to the possible efficacy of other remedies, and confirming a statistically significant effect of high dilutions of neurotrophic molecules and antibodies. In the second part of this paper we report some recent results obtained in our laboratory, testing Aconitum, Nux vomica, Belladonna, Argentum nitricum, Tabacum (all 5CH potency) and Gelsemium (5, 7, 9 and 30CH potencies) on mice using ethological models of behaviour. The test was performed using coded drugs and controls in double blind (operations and calculations). After an initial screening that showed all the tested remedies (except for Belladonna) to have some effects on the behavioural parameters (light-dark test and open-field test), but with high experimental variability, we focused our study on Gelsemium, and carried out two complete series of experiments. The results showed that Gelsemium had several effects on the exploratory behaviour of mice, which in some models were highly statistically significant (p < 0.001), in all the dilutions/dynamizations used, but with complex differences according to the experimental conditions and test performed. Finally, some methodological issues of animal research in this field of homeopathy are discussed. The "Gelsemium model" - encompassing experimental studies in vitro and in vivo from different laboratories and with different methods, including significant effects of its major active principle gelsemine - may play a pivotal rule for investigations on other homeopathic remedies.

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Section: Catalepsy and Convulsion Modelsmentioning

confidence: 99%

Assays of homeopathic remedies in rodent behavioural and psychopathological models

et al. 2009

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“…Using research from animal study [1], knowledge of homeopathic Materia Medica and the homeopathic historical use of Nux Vomica for symptoms of hangover relief and alcohol problems, we instituted a protocol using a genus epidemicus model of treatment, that is identification of a remedy based on the collective signs and symptoms of a group rather than personalized individuated case analysis [2]. All clients entering the program were offered a single dose of Nux Vomica 200c after briefly being introduced to homeopathy and our understanding of its usefulness in reducing cravings for alcohol and other drugs.…”

Section: Resultsmentioning

confidence: 99%

Use of Homeopathic Nux Vomica in Reducing PAWS (Post acute withdrawal syndrome) in Early Recovering Addicted Women

Butehorn¹

2017

IJCAM

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“…Com relação às investigações que utilizam extratos de plantas, há poucos estudos aprofundados, embora o uso e efeitos de plantas com relação ao álcool, em humanos, já tenham sido relatados ao redor do planeta com uma variedade grande de espécies (Liu et al, 2011;Tomczyk et al, 2012). A respeito de avaliações do efeito do extrato de plantas de uma mesma espécie no consumo de álcool em animais experimentais podem ser citados uso de Hipericum perforatum nas linhagens Fawn-Hooded e High Alcohol Drinking (Rezvani et al, 1999) e Strychnos nux-vomica em ratos da linhagem Charles Foster (Sukul et al, 2001). Há outros trabalhos, entretanto os compostos de plantas foram isolados e só então administrados, como por exemplo, o realizado por Keung e Vallee (1993), onde daidzina e daidzeina obtidos da Radix pueraria foram administrados em FIGURA 2.…”

Section: Discussionunclassified

O extrato bruto hidroalcoólico das folhas de Piper caldense C. DC. na redução do consumo de álcool em ratos.

Pereira

Guedes

Silva

2015

Rev. bras. plantas med.

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RESUMO:A investigação de plantas medicinais como recurso terapêutico para combater o alcoolismo ainda é muito insipiente com poucas espécies investigadas. No presente trabalho avaliamos o efeito do extrato hidroalcoólico das folhas da planta Piper caldense C. DC. com relação ao consumo de álcool e também a sua potencialidade ansiolítica. Foram utilizados ratos Wistar machos, os quais foram divididos em grupos controle (solução fisiológica) e tratado (extrato da planta nas doses de 25, 50 e 150 mg/kg, e diazepam 2 mg/kg). Os animais foram tratados através da via intraperitoneal 1 h antes dos experimentos. Os modelos animais utilizados foram: Labirinto em Cruz Elevado (LCE) e auto-administração de álcool (AA). No LCE o extrato não apresentou efeito ansiolítico do tipo benzodiazepínico. Por outro lado, no comportamento relacionado a auto-administração de solução de álcool, o extrato apresentou efeito significativo reduzindo o consumo de álcool em relação ao grupo controle. Apesar do extrato não ter apresentado efeito ansiolítico, o mesmo parece apresentar potencialidades para combater o abuso e a dependência de álcool. PALAVRAS-CHAVE:Piper caldense C. DC., labirinto em cruz elevado, auto-administração de álcool.ABSTRACT: The hydroalcoholic extract of leaves of Piper caldense C. DC. decreases alcohol consumption in rats. The investigation of medicinal plants as therapeutic resources in the combat of alcoholism is still very incipient with few species being investigated. The purpose of the present study was to examine the effects of the hydroalcoholic extract of leaves of Piper caldense C. DC. in relation to alcohol consumption and also its anxiolytic potentiality. Male Wistar rats, which had been separated into control group (saline) and treated group (Plant extract doses of 25, 50 and 150 mg/kg and 2 mg/kg of diazepam), were used. Animals were injected intraperitoneally 1 h before the tests. The following models were used: Elevated plus maze (EPM) and alcohol self-administration (ASA). In the EPM, the extract did not show benzodiazepine anxiolytic effect. On the other hand, in the behavior related to alcohol self-administration, the extract showed a significant effect, reducing alcohol consumption compared to the control group. Although the extract has not shown any anxiolytic effect, the results suggest that the plant has potential to combat alcohol abuse and addiction.Key words: Piper caldense C. DC., elevated plus maze, alcohol self-administration.10.1590/1983-084X/12_145 INTRODUÇÃOA busca por novos fármacos que possam combater o alcoolismo é um desafio constante tendo rendido até o momento três fármacos clinicamente bem estabelecidos, dissulfiram (Suh et al., 2006), naltrexona (Johnson B.A., 2008) e acamprosato (Mason & Heyser, 2010). Mesmo assim, a eficácia destes medicamentos é relativa (Popova et al., 2011), portanto a busca por outros fármacos é fundamental. Um campo a ser explorado é o das plantas medicinais, como este é muito amplo, uma maneira de delimitá-lo é estudar plantas que apresentam alguma ação s...

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Strychnos nux-vomica Extract and Its Ultra-High Dilution Reduce Voluntary Ethanol Intake in Rats

Abstract: Nux MT and Nux 30c could reduce ethanol intake in rats. The altered solution structure of Nux 30c is thought to mimic Nux MT and produce ethanol aversion in rats.

Cited by 33 publications

References 8 publications

Assays of homeopathic remedies in rodent behavioural and psychopathological models

Assays of homeopathic remedies in rodent behavioural and psychopathological models

Use of Homeopathic Nux Vomica in Reducing PAWS (Post acute withdrawal syndrome) in Early Recovering Addicted Women

O extrato bruto hidroalcoólico das folhas de Piper caldense C. DC. na redução do consumo de álcool em ratos.

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