Studi Literatur: Potensi Tanaman Herbal Indonesia sebagai Imunostimulan dan Anti-stress untuk Pencegahan Covid-19 Berbasis Evidence-based Analysis

Suciady, Meithavia; Meiliana, Meiliana; Hendryanti, Dea Nathania

doi:10.24167/praxis.v4i1.3607

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…Beberapa senyawa tertentu yang bersifat imunostimulan dapat meningkatkan mekanisme pertahanan tubuh. Imunostimulan dapat dikatakan sebagai senyawa yang dapat meningkatkan mekanisme pertahanan tubuh baik secara spesifik maupun nonspesifik, baik mekanisme pertahanan seluler maupun humoral (Suciady, 2021). Oleh karena itu, adanya senyawa kimia yang diperoleh dari tumbuh-tumbuhan dapat meningkatkan aktivitas sistem imun dan senyawa-senyawa tersebut (Setyaningrum, 2019).…”

Section: Pendahuluanunclassified

Penyuluhan dan Pelatihan Penggunaan Obat Tradisional serta Penerapan Hasil Penelitian Tumbuhan Sungkai (Peronema canescens Jack) kepada Masyarakat

Dillasamola¹,

Aldi²,

Wahyuni³

et al. 2023

jwa

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Indonesians, particularly those residing in rural areas with abundant plant diversity, have long relied on traditional medicine that utilizes plants. Sungkai (Peronema canescens Jack.) is one example of a widely-used traditional medicine known for its immunity-boosting properties. However, many people need more awareness of the potential benefits and risks of plants like Sungkai, so it is necessary to provide education and training to promote proper usage and ensure public safety. This community service activity aimed to equip individuals with the knowledge and skills to process plants accurately, utilize them appropriately based on the severity of the illness, and avoid any adverse side effects or toxicity. The counselling method used in this initiative involves lectures, which is effective for individuals with varying education levels, especially the general public. This program has yielded promising results, with the community displaying strong enthusiasm for the initiative. Ultimately, education and counselling services can significantly improve public understanding and use of traditional medicine.

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Section: Pendahuluanunclassified

Penyuluhan dan Pelatihan Penggunaan Obat Tradisional serta Penerapan Hasil Penelitian Tumbuhan Sungkai (Peronema canescens Jack) kepada Masyarakat

Dillasamola¹,

Aldi²,

Wahyuni³

et al. 2023

jwa

View full text Add to dashboard Cite

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“…It had shown a high similarity to other coronaviruses, including SARS. Covid-19, caused by the SARS-CoV-2 virus, was classified as a β-coronavirus and represented an acute respiratory disease that infected humans, for which humans did not possess a natural immune defense against this pathogen [1].…”

Section: Introductionmentioning

confidence: 99%

Molecular Docking of Secondary Metabolite Compounds of Andrographis Paniculata Plant as Potential Covid-19 Drug Candidate

Ishak,

La Kilo,

Halidi

et al. 2023

J. Sains Kes.

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The aim of this research was to investigate the interaction between secondary metabolite compounds and the Mpro receptor, which was the main protein in Covid-19. Ligand-receptor interactions were studied using the Molecular Docking method. The validation results indicated that the test ligand Andrographolide had a higher affinity value compared to the standard ligand, with a value of -6.6 kcal/mol compared to the standard ligand's -7.5 kcal/mol. Additionally, the compound 14-Acetyl-3,19-isopropylideneandrographolide, 5,4 dihydroxy-7,8,2',3'-tetramethoxyflavone-5-glucoside had an affinity of -7.5 kcal/mol, Andrographidin A had -7.6 kcal/mol, Andrographiside had -7.7 kcal/mol, Skullcapflavone I had 7.7 kcal/mol, 5-Hydroxy-7,8,2'-trimethoxyflavone-5-glucoside had -7.7 kcal/mol, Apigenin had 7.7 kcal/mol, 5-Hydroxy-7,8-dimethoxyflavone-5-glucoside had -7.8 kcal/mol, Neoandrographolide had -7.8 kcal/mol, Andropanoside had -7.9 kcal/mol, Wogonin-5 glucoside had -8.1 kcal/mol, 5,2',3'-Trihydroxy-7,8-dimethoxyflavone-3'-glucoside had -8.4 kcal/mol, and Bisandrographolide had -8.5 kcal/mol. From the molecular docking results, the secondary metabolite compounds from the Andrographis paniculata plant exhibited significant interactions surpassing the standard ligand N3. Active residue interactions observed included Phe140, Leu141, Asn142, Gly143, His163, Glu166, Gln189, and Thr190.

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Studi Literatur: Potensi Tanaman Herbal Indonesia sebagai Imunostimulan dan Anti-stress untuk Pencegahan Covid-19 Berbasis Evidence-based Analysis

Cited by 2 publications

References 20 publications

Penyuluhan dan Pelatihan Penggunaan Obat Tradisional serta Penerapan Hasil Penelitian Tumbuhan Sungkai (Peronema canescens Jack) kepada Masyarakat

Penyuluhan dan Pelatihan Penggunaan Obat Tradisional serta Penerapan Hasil Penelitian Tumbuhan Sungkai (Peronema canescens Jack) kepada Masyarakat

Molecular Docking of Secondary Metabolite Compounds of Andrographis Paniculata Plant as Potential Covid-19 Drug Candidate

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