Studies in medicinal plants. Part III. Protoberberine alkaloids from the roots ofCissampelos pareira linn

Anwer, F.; Popli, S. P.; Srivastava, Rohit; Khare, Maheshwari P.

doi:10.1007/bf02138704

Cited by 26 publications

(9 citation statements)

References 5 publications

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“…[4] Cissampelos pareira is reported to have cardioprotective,[5] hepatoprotective,[6] antioxidant and immunomodulatory,[7] antifertility,[8] antiarthritic,[9] and anti-inflammatory activities. [10] The plant is reported to have phytoconsituents like cissampeloflavone,[11] cissamparine,[12] pareirubrines A and B,[13] hayatinin,[14] and protoberberine alkaloids. [15] No pharmacological investigation in the perspective of antitumor activity has yet been reported on C. pariera .…”

Section: Introductionmentioning

confidence: 99%

Anticancer activity of cissampelos pareira against dalton′s lymphoma ascites bearing mice

Thavamani¹,

Mathew²,

Dhanabal

2014

Phcog Mag

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Background:Cissampelos pareira (Menispermaceae) is used in folk Indian system of alternative medicine, for its analgesic, antipyretic, diuretic, antilithic, and emmenagogue properties.Objective:To evaluate Cissampelos pareira (C. pareira) for in vitro cytotoxicity and in vivo antitumor activity against Dalton's Lymphoma Ascites (DLA) cells in Swiss mice.Materials and Methods:Cissampelos pareira was successively extracted using different solvents. In vitro cytotoxicity was assessed by the MTT assay. An in vivo study was carried out in methanol extract. Twenty-four hours after intraperitoneal inoculation of the DLA cells in mice, the methanol extract of C. pariera (MECP) was administered at 200 and 400 mg/kg body weight for 14 consecutive days. On day 14, six mice were sacrificed and the rest were kept alive for assessment of increase in life-span. The antitumor effect was assessed by evaluating the packed cell volume, viable tumor cell count, increase in body weight, and increase in life-span. The hematological and serum biochemical parameters and anti-oxidant properties were assessed by estimating the superoxide dismutase (SOD), catalase (CAT), and lipid peroxidation.Results:Methanol Extract of Cissampelos pariera (MECP) showed a potent cytotoxic activity, with an IC50 value of 95.5 μg/ml and a significant (P < 0.001) decrease in packed cell volume, viable cell count, and an increased lifespan (54 and 72%). The hematological and serum biochemical profiles were restored to normal levels in MECP-treated mice. The MECP-treated group significantly (P < 0.001) decreased SOD, lipid peroxidation, and CAT to normal.Conclusion:This study demonstrated that C. pariera exhibited significant in vitro and in vivo anti-tumor activities and that it was reasonably imputable to its increasing endogenous mechanism of antioxidant property.

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Section: Introductionmentioning

confidence: 99%

Anticancer activity of cissampelos pareira against dalton′s lymphoma ascites bearing mice

Thavamani¹,

Mathew²,

Dhanabal

2014

Phcog Mag

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“…Tetrandrine [12] and berberine [13] were previously isolated from C. pareira roots. They were also reported for their antioxidant activity in various models [14, 15].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and Immunomodulatory Activity of the Alkaloidal Fraction of Cissampelos pareira Linn.

Bafna

2010

Sci. Pharm.

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The alkaloidal fraction (AFCP) of roots of Cissampelos pareira Linn. was screened for in-vitro antioxidant activity and immunomodulatory activity in mice. The HPTLC finger print profile was also established for the identification of AFCP which was found to contain 0.176 % of berberine. AFCP possess strong antioxidant activity which was revealed by its ability to scavenge the stable free radical DPPH, superoxide ion and to inhibit lipid peroxidation in rat liver homogenate induced by iron/ADP/Ascorbate complex. AFCP was found to have significant immunosuppressive activity at lower doses (25 and 50 mg/kg) while no activity was observed at higher doses (75 and 100 mg/kg). Humoral antibody titre was significantly (p<0.01) lowered by AFCP at the doses of 25 and 50 mg/kg. Delayed type hypersensitivity response was also significantly (p<0.01) suppressed by the AFCP at the dose of 75 mg/kg. Thus the present study revealed the immunosuppressive and antioxidant activities of the alkaloidal fraction of C. pareira roots.

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“…Alkaloids such as bebecrine, hyatin, tetrandine, berberine, bebeerine, cissampareine, cissamine, pareirubrine A and B, buxine, pareitropone, and trandrine have been reported in C. pareira [6,[12][13][14][15][16]. Alkaloids berberine and tetrandine have been reported to demonstrate antioxidant activity and this activity could be responsible for the various biological activities associated with this plant including antidiabetic activity.…”

Section: Discussionmentioning

confidence: 99%

“…The compounds isolated from C. pareira includes alkaloids such as bebeerine, bebecrine, buxine, cissampareine, cissamine, cycleanine, d-4"-O-methylbebeerine, dehydrodicentrine, dicentrine, grandirubine, haytinin, haytidin, isochondrodendrine, isoimerubrine, isularine, pareirubrine A and B, pareirubrine, pareitropone, and tetrandine; flavone cissampeloflavone; quercetin such as 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one; fatty acids such as linoleic acid, arachidic acid and stearic acid; sterols such as β-sitosterol and other compounds including bulbocaprine, corytuberine, curine, cyclanoline, dimethyltetrandrinium, laudanosine, magnoflorine, menismine, norimeluteine, norruffscine, nuciferine, and quercitol [6,[11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Antidiabetic Activity and Safety In Rats of Cissampelos pareira Traditionally Used In The Management of Diabetes Mellitus In Embu County, Kenya

Ngugi¹,

Eliud²,

Susan

et al. 2015

J Drug Metab Toxicol

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Cissampelos pareira Linn has been used traditionally in the management of several diseases including diabetes mellitus but its efficacy and safety after long term use is not scientifically evaluated. The aim of this study was to determine in vivo hypoglycemic activity and safety of aqueous leaf extracts of C. pareira in white male albino rats. The extracts were screened for their hypoglycemic activity in alloxan induced diabetic rats using the oral and intraperitoneal routes. The safety of these extracts was studied in rats orally or intraperitoneally administered with 1 g/kg body weight daily for 28 days by recording the changes in body and organ weight, hematological and biochemical parameters and histology. Mineral composition of the extracts were estimated using total reflection X-ray fluorescence system (TRXF) while the types and quantities of phytochemicals present were assessed using standard procedures. Aqueous extracts orally and intraperitoneally administered at 50 mg/kg, 100 mg/kg and 150 mg/kg body weight demonstrated hypoglycemic activity with the intraperitoneal route being more effective than the oral route. Oral and intraperitoneal dose of 1 g/kg body weight of the leaf extracts significantly reduced the body weight gain. The same intraperitoneal dose increased the liver and spleen, and decreased the testis weight; and reduced the hemoglobin levels, packed cell volume and increased the platelet count; increased the activity of aspartate aminotransferase, and lactate dehydrogenase, and decreased the activity of alkaline phosphatase, γ-glutamyltransferase, and creatine kinase and histologically slightly injured the liver and spleen and orally increased the activity of alanine aminotransferase, lactate dehydrogenase, and creatine kinase, and decreased the activity of aspartate aminotransferase and γ-glutamyltransferase. The extracts contained phenols, tannins, flavonoids, alkaloids, terpenoids, sterols, and reducing sugars. Potassium, calcium, and iron levels in the extracts were below the recommended daily allowance. In conclusion, the observed hypoglycemic activity and slight toxicity could be associated with the phytonutrients present in this plant extract. This study recommends continued use of this plant as an herbal medicine.

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Studies in medicinal plants. Part III. Protoberberine alkaloids from the roots ofCissampelos pareira linn

Cited by 26 publications

References 5 publications

Anticancer activity of cissampelos pareira against dalton′s lymphoma ascites bearing mice

Anticancer activity of cissampelos pareira against dalton′s lymphoma ascites bearing mice

Antioxidant and Immunomodulatory Activity of the Alkaloidal Fraction of Cissampelos pareira Linn.

In Vivo Antidiabetic Activity and Safety In Rats of Cissampelos pareira Traditionally Used In The Management of Diabetes Mellitus In Embu County, Kenya

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