This study was undertaken as a part of the problem of predicting the irreversible thermal injury of skin. Of first importance in this problem is the determination of the temperatiire-time-depth history of skin subjected to an arbitrary thermal insult. Although this paper deals with radiant energy heating of skin, it is intended that the results may be applied to other modes of energy input, as well.The theoretical analysis of heat flow in irradiated skin is considered first, and the predicted responses of two models are presented. Methods are developed for the comparison of these theoretical predictions with experimental resultsJ these comparison schemes define the experimental procedures and materials which are next described in detail. Finally, the experimental results are presented, together with an evaluation of the constants of skin, whenever possible» While the experimental results failed to supply all the information necessary to compute the temperature response of skin to any arbitrary energy input, several important conclusions were reached. A most interesting result of the theoretical analysis is that the absorption pattern of radiation in skin may be determined directly by temperature measurements, and the data may be tested rigorously for their validity. Also, it is now possible to plan future experiments which will provide the necessary data which this study failed to supply. Most important is the indication that the desired prediction of thermal injury of skin may be achieved. ill