Studies of Interactions of Valsartan, Glimepiride and Ciprofloxacin HCl by DSC and HPLC

Rahman, M. Habibur; Salam, Abdus; Rahman, Asma; Sultan, Zakir

doi:10.3329/bpj.v20i2.37885

Cited by 3 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the current study, DM caused the elevation of MDA levels. The biological and pharmacological activities of the novel complexes of Dapg with Zn, Cr and/or Se ameliorated the hepatic functions and rejuvenated the antioxidant defense system [55]. The present study demonstrated that DM induced hepatotoxicity and severe oxidative stress, which could be mitigated by the administration of Dapg metal complexes with Zn, Cr and/or Se.…”

Section: Discussionsupporting

confidence: 51%

Synthesis and Spectroscopic Characterization of Dapagliflozin/Zn (II), Cr (III) and Se (IV) Novel Complexes That Ameliorate Hepatic Damage, Hyperglycemia and Oxidative Injury Induced by Streptozotocin-Induced Diabetic Male Rats and Their Antibacterial Activity

et al. 2022

View full text Add to dashboard Cite

Diabetes mellitus (DM) causes an imbalance in the oxidative status of the human body. Three novel Dapagliflozin (Dapg) Zn (II), Cr (III) and Se (IV) complexes were prepared and characterized by elemental analysis, IR, electronic spectra, magnetic susceptibility, scanning electron microscopy (SEM) and X-ray diffraction. The molar conductance values confirmed the non-electrolytic nature of the Dapg complexes. According to spectral data, Dapg acts as a bidentate ligand. The thermal analyses of the complexes were studied using the DSC technique. The surface morphology and particle sizes of the Dapg complexes were investigated using SEM and XRD. XRD confirmed the crystalline structure for the complexity. This study investigated the effect of novel metal complexes of Dapg with the metals Zn (II), Cr (III) and Se (IV) on oxidative injury and tissue damage in the hepatic tissue of streptozotocin (STZ)-induced diabetic male rats. DM was experimentally induced in male rats. The diabetic rats received Dapg, Dapg/Zn, Dapg/Cr and Dapg/Se orally for 30 successive days. Male rats exposed to STZ showed multi-histopathological alterations in their hepatic tissue, including inflammatory and structural changes. STZ elevated oxidative stress markers in the hepatic tissue and lowered the antioxidant defense enzymes. Supplementation of Dapg with Zn, Cr or Se novel complexes significantly prevented hepatic injury and suppressed the generation of reactive oxygen species. The Dapg/Zn complex was highly effective against Bacillus subtilis and Streptococcus penumonia, while Dapg/Cr was highly effective against Escherichia coli and Pseudomonas aeruginosa, and Dapg/Se was highly effective against Staphylococcus aureas. In conclusion, Dapg novel metal complexes with Zn, Cr or Se protect against oxidative injury and the pathophysiological and bacterial complications of DM and hepatic tissue injury. The Dapg novel metal complexes improved hepatic functions, reduced blood glucose levels and enhanced the levels of antioxidant defense enzymes in diabetic male rats.

show abstract

Section: Discussionsupporting

confidence: 51%

Synthesis and Spectroscopic Characterization of Dapagliflozin/Zn (II), Cr (III) and Se (IV) Novel Complexes That Ameliorate Hepatic Damage, Hyperglycemia and Oxidative Injury Induced by Streptozotocin-Induced Diabetic Male Rats and Their Antibacterial Activity

et al. 2022

View full text Add to dashboard Cite

show abstract

Thermochemical Properties and Bioactivity of the Metallic Complexes of Levofloxacin

Tahia

Sultan

Islam

et al. 2019

Asian J. Org. Med. Chem.

View full text Add to dashboard Cite

The aim of this study was complexation of levofloxacin with iron, calcium, copper and ammonium salts. The formation of the metal complexes were confirmed by TLC and FT-IR. The newly formed metal complexes showed characteristics thermochemical behaviours such as differential scanning calorimetric and thermo gravimetric properties along with bioactivity. Additionally, the synthesized metal complexes have shown some extents of antimicrobial activities. It is concluded that the potentiality of metal-levofloxacin complexes are due to the action and presence of siderophores within bacterial cells.

show abstract

Chromium (III) Complexes of Metformin, Dapagliflozin, Vildagliptin and Glimepiride Potentiate Antidiabetic Activity in Animal Model

Aktar¹,

Sultan²,

Rashid³

2021

IJCRR

View full text Add to dashboard Cite

Studies of Interactions of Valsartan, Glimepiride and Ciprofloxacin HCl by DSC and HPLC

Cited by 3 publications

References 13 publications

Synthesis and Spectroscopic Characterization of Dapagliflozin/Zn (II), Cr (III) and Se (IV) Novel Complexes That Ameliorate Hepatic Damage, Hyperglycemia and Oxidative Injury Induced by Streptozotocin-Induced Diabetic Male Rats and Their Antibacterial Activity

Synthesis and Spectroscopic Characterization of Dapagliflozin/Zn (II), Cr (III) and Se (IV) Novel Complexes That Ameliorate Hepatic Damage, Hyperglycemia and Oxidative Injury Induced by Streptozotocin-Induced Diabetic Male Rats and Their Antibacterial Activity

Thermochemical Properties and Bioactivity of the Metallic Complexes of Levofloxacin

Chromium (III) Complexes of Metformin, Dapagliflozin, Vildagliptin and Glimepiride Potentiate Antidiabetic Activity in Animal Model

Contact Info

Product

Resources

About